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Measuring single cell divisions in human tissues from multi-region sequencing data.
Benjamin Werner, Jack Case, Marc J Williams, Ketevan Chkhaidze, Daniel Temko, Javier Fernández-Mateos, George D Cresswell, Daniel Nichol, William Cross, Inmaculada Spiteri, Weini Huang, Ian PM Tomlinson, Chris P Barnes, Trevor A Graham, Andrea Sottoriva
Feb 24, 2021
Both normal tissue development and cancer growth are driven by a branching process of cell division and mutation accumulation that leads to intra-tissue genetic heterogeneity. However, quantifying somatic evolution in humans...