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A Novel Retrieval-Dependent Memory Process Revealed by the Arrest of ERK1/2 Activation in the Basolateral Amygdala.
Fully consolidated fear memories can be maintained or inhibited by retrieval-dependent mechanisms depending on the degree of re-exposure to fear cues. Short exposures promote memory maintenance through reconsolidation, and long...
GKAP Acts as a Genetic Modulator of NMDAR Signaling to Govern Invasive Tumor Growth.
Leanne Li, Qiqun Zeng, Arjun Bhutkar, José A Galván, Eva Karamitopoulou, Daan Noordermeer, Mei-Wen Peng, Alessandra Piersigilli, Aurel Perren, Inti Zlobec, Hugh Robinson, M Luisa Iruela-Arispe, Douglas Hanahan
Jun 28, 2018
Genetic linkage analysis previously suggested that GKAP, a scaffold protein of the N-methyl-D-aspartate receptor (NMDAR), was a potential modifier of invasion in a mouse model of pancreatic neuroendocrine tumor (PanNET). Here...
FMRP GKAP/Dlgap1 GluN2b/NR2b/Grin2b HSF1 MK801 NMDAR RIP1Tag2 cancer modifier glutamate receptor Memantine pancreatic ductal adenocarcinoma (PDAC) Animals Antineoplastic Agents Carcinoma Neuroendocrine Carcinoma Pancreatic Ductal Cell Line Tumor Fragile X Mental Retardation Protein Gene Expression Profiling Gene Expression Regulation Neoplastic Heat Shock Transcription Factors Humans Mice Neoplasm Invasiveness Neoplasm Transplantation Pancreatic Neoplasms Prognosis Receptors N-Methyl-D-Aspartate SAP90-PSD95 Associated Proteins Sequence Analysis RNA Signal Transduction Survival Analysis