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Drug-perturbation-based stratification of blood cancer.
Sascha Dietrich, Małgorzata Oleś, Junyan Lu, Leopold Sellner, Simon Anders, Britta Velten, Bian Wu, Jennifer Hüllein, Michelle da Silva Liberio, Tatjana Walther, Lena Wagner, Sophie Rabe, Sonja Ghidelli-Disse, Marcus Bantscheff, Andrzej K Oleś, Mikołaj Słabicki, Andreas Mock, Christopher C Oakes, Shihui Wang, Sina Oppermann, Marina Lukas, Vladislav Kim, Martin Sill, Axel Benner, Anna Jauch, Lesley Ann Sutton, Emma Young, Richard Rosenquist, Xiyang Liu, Alexander Jethwa, Kwang Seok Lee, Joe Lewis, Kerstin Putzker, Christoph Lutz, Davide Rossi, Andriy Mokhir, Thomas Oellerich, Katja Zirlik, Marco Herling, Florence Nguyen-Khac, Christoph Plass, Emma Andersson, Satu Mustjoki, Christof von Kalle, Anthony D Ho, Manfred Hensel, Jan Dürig, Ingo Ringshausen, Marc Zapatka, Wolfgang Huber, Thorsten Zenz
Mar 08, 2018
As new generations of targeted therapies emerge and tumor genome sequencing discovers increasingly comprehensive mutation repertoires, the functional relationships of mutations to tumor phenotypes remain largely unknown. Here...
Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels.
Adrienne Tin, Jonathan Marten, Victoria L Halperin Kuhns, Yong Li, Matthias Wuttke, Holger Kirsten, Karsten B Sieber, Chengxiang Qiu, Mathias Gorski, Zhi Yu, Ayush Giri, Gardar Sveinbjornsson, Man Li, Audrey Y Chu, Anselm Hoppmann, Luke J O'Connor, Bram Prins, Teresa Nutile, Damia Noce, Masato Akiyama, Massimiliano Cocca, Sahar Ghasemi, Peter J van der Most, Katrin Horn, Yizhe Xu, Christian Fuchsberger, Sanaz Sedaghat, Saima Afaq, Najaf Amin, Johan Ärnlöv, Stephan JL Bakker, Nisha Bansal, Daniela Baptista, Sven Bergmann, Mary L Biggs, Ginevra Biino, Eric Boerwinkle, Erwin P Bottinger, Thibaud S Boutin, Marco Brumat, Ralph Burkhardt, Eric Campana, Archie Campbell, Harry Campbell, Robert J Carroll, Eulalia Catamo, John C Chambers, Marina Ciullo, Maria Pina Concas, Josef Coresh, Tanguy Corre, Daniele Cusi, Sala Cinzia Felicita, Martin H de Borst, Alessandro De Grandi, Renée de Mutsert, Aiko PJ de Vries, Graciela Delgado, Ayşe Demirkan, Olivier Devuyst, Katalin Dittrich, Kai-Uwe Eckardt, Georg Ehret, Karlhans Endlich, Michele K Evans, Ron T Gansevoort, Paolo Gasparini, Vilmantas Giedraitis, Christian Gieger, Giorgia Girotto, Martin Gögele, Scott D Gordon, Daniel F Gudbjartsson, Vilmundur Gudnason, German Chronic Kidney Disease Study, Toomas Haller, Pavel Hamet, Tamara B Harris, Caroline Hayward, Andrew A Hicks, Edith Hofer, Hilma Holm, Wei Huang, Nina Hutri-Kähönen, Shih-Jen Hwang, M Arfan Ikram, Raychel M Lewis, Erik Ingelsson, Johanna Jakobsdottir, Ingileif Jonsdottir, Helgi Jonsson, Peter K Joshi, Navya Shilpa Josyula, Bettina Jung, Mika Kähönen, Yoichiro Kamatani, Masahiro Kanai, Shona M Kerr, Wieland Kiess, Marcus E Kleber, Wolfgang Koenig, Jaspal S Kooner, Antje Körner, Peter Kovacs, Bernhard K Krämer, Florian Kronenberg, Michiaki Kubo, Brigitte Kühnel, Martina La Bianca, Leslie A Lange, Benjamin Lehne, Terho Lehtimäki, Lifelines Cohort Study, Jun Liu, Markus Loeffler, Ruth JF Loos, Leo-Pekka Lyytikäinen, Reedik Magi, Anubha Mahajan, Nicholas G Martin, Winfried März, Deborah Mascalzoni, Koichi Matsuda, Christa Meisinger, Thomas Meitinger, Andres Metspalu, Yuri Milaneschi, V. A. Million Veteran Program, Christopher J O'Donnell, Otis D Wilson, J Michael Gaziano, Pashupati P Mishra, Karen L Mohlke, Nina Mononen, Grant W Montgomery, Dennis O Mook-Kanamori, Martina Müller-Nurasyid, Girish N Nadkarni, Mike A Nalls, Matthias Nauck, Kjell Nikus, Boting Ning, Ilja M Nolte, Raymond Noordam, Jeffrey R O'Connell, Isleifur Olafsson, Sandosh Padmanabhan, Brenda WJH Penninx, Thomas Perls, Annette Peters, Mario Pirastu, Nicola Pirastu, Giorgio Pistis, Ozren Polasek, Belen Ponte, David J Porteous, Tanja Poulain, Michael H Preuss, Ton J Rabelink, Laura M Raffield, Olli T Raitakari, Rainer Rettig, Myriam Rheinberger, Kenneth M Rice, Federica Rizzi, Antonietta Robino, Igor Rudan, Alena Krajcoviechova, Renata Cifkova, Rico Rueedi, Daniela Ruggiero, Kathleen A Ryan, Yasaman Saba, Erika Salvi, Helena Schmidt, Reinhold Schmidt, Christian M Shaffer, Albert V Smith, Blair H Smith, Cassandra N Spracklen, Konstantin Strauch, Michael Stumvoll, Patrick Sulem, Salman M Tajuddin, Andrej Teren, Joachim Thiery, Chris HL Thio, Unnur Thorsteinsdottir, Daniela Toniolo, Anke Tönjes, Johanne Tremblay, André G Uitterlinden, Simona Vaccargiu, Pim van der Harst, Cornelia M van Duijn, Niek Verweij, Uwe Völker, Peter Vollenweider, Gerard Waeber, Melanie Waldenberger, John B Whitfield, Sarah H Wild, James F Wilson, Qiong Yang, Weihua Zhang, Alan B Zonderman, Murielle Bochud, James G Wilson, Sarah A Pendergrass, Kevin Ho, Afshin Parsa, Peter P Pramstaller, Bruce M Psaty, Carsten A Böger, Harold Snieder, Adam S Butterworth, Yukinori Okada, Todd L Edwards, Kari Stefansson, Katalin Susztak, Markus Scholz, Iris M Heid, Adriana M Hung, Alexander Teumer, Cristian Pattaro, Owen M Woodward, Veronique Vitart, Anna Köttgen
Oct 17, 2019
ATP Binding Cassette Transporter Subfamily G Member 2 Cardiovascular Diseases Cohort Studies Genetic Loci Genetic Markers Genetic Predisposition to Disease Genome-Wide Association Study gout Hepatocyte Nuclear Factor 1-alpha Hepatocyte Nuclear Factor 4 Humans Kidney Liver Metabolic Diseases Neoplasm Proteins Organ Specificity Polymorphism Single Nucleotide Signal Transduction Uric Acid
Genome-wide Estrogen Receptor-α activation is sustained, not cyclical.
Estrogen Receptor-alpha (ER) drives 75% of breast cancers. Stimulation of the ER by estra-2-diol forms a transcriptionally-active chromatin-bound complex. Previous studies reported that ER binding follows a cyclical pattern....
Estrogen estrogen receptor MCF7 Breast Cancer Chromosomes Computational Biology endocrine Gene Expression human Systems Biology Base Sequence Binding Sites Estradiol Estrogen Receptor alpha Female Gene Expression Regulation Neoplastic Genome Human Genome-Wide Association Study Humans MCF-7 Cells Neoplasm Proteins Promoter Regions Genetic Protein Binding Receptors CXCR Signal Transduction Sorting Nexins Trefoil Factor-1
Progression of mouse skin carcinogenesis is associated with increased ERα levels and is repressed by a dominant negative form of ERα.
Stella Logotheti, Dimitra Papaevangeliou, Ioannis Michalopoulos, Maria Sideridou, Katerina Tsimaratou, Ioannis Christodoulou, Katerina Pyrillou, Vassilis Gorgoulis, Spiros Vlahopoulos, Vassilis Zoumpourlis
Oct 03, 2018
Estrogen receptors (ER), namely ERα and ERβ, are hormone-activated transcription factors with an important role in carcinogenesis. In the present study, we aimed at elucidating the implication of ERα in skin cancer, using...
Ninein is essential for apico-basal microtubule formation and CLIP-170 facilitates its redeployment to non-centrosomal microtubule organizing centres.
Deborah A Goldspink, Chris Rookyard, Benjamin J Tyrrell, Jonathan Gadsby, James Perkins, Elizabeth K Lund, Niels Galjart, Paul Thomas, Tom Wileman, Mette M Mogensen
Oct 10, 2018
Differentiation of columnar epithelial cells involves a dramatic reorganization of the microtubules (MTs) and centrosomal components into an apico-basal array no longer anchored at the centrosome. Instead, the minus-ends of the...
CLIP-170 IQGAP1 Rac1 Microtubules ninein non-centrosomal MTOCs Animals Cell Differentiation Cell Line Cell Polarity Cell Shape Cytoskeletal Proteins Dogs Epithelial Cells Gene Knockout Techniques Humans Madin Darby Canine Kidney Cells Mice Microtubule-Associated Proteins Microtubule-Organizing Center Microtubules Neoplasm Proteins
Therapeutic relevance of the PP2A-B55 inhibitory kinase MASTL/Greatwall in breast cancer.
Mónica Álvarez-Fernández, María Sanz-Flores, Belén Sanz-Castillo, María Salazar-Roa, David Partida, Elisabet Zapatero-Solana, H Raza Ali, Eusebio Manchado, Scott Lowe, Todd VanArsdale, David Shields, Carlos Caldas, Miguel Quintela-Fandino, Marcos Malumbres
Apr 29, 2019
PP2A is a major tumor suppressor whose inactivation is frequently found in a wide spectrum of human tumors. In particular, deletion or epigenetic silencing of genes encoding the B55 family of PP2A regulatory subunits is a common...
Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis.
Chun Gong, Joanna A Krupka, Jie Gao, Nicholas F Grigoropoulos, George Giotopoulos, Ryan Asby, Michael Screen, Zelvera Usheva, Francesco Cucco, Sharon Barrans, Daniel Painter, Nurmahirah Binte Mohammed Zaini, Björn Haupl, Susanne Bornelöv, Igor Ruiz De Los Mozos, Wei Meng, Peixun Zhou, Alex E Blain, Sorcha Forde, Jamie Matthews, Michelle Guet Khim Tan, GA Amos Burke, Siu Kwan Sze, Philip Beer, Cathy Burton, Peter Campbell, Vikki Rand, Suzanne D Turner, Jernej Ule, Eve Roman, Reuben Tooze, Thomas Oellerich, Brian J Huntly, Martin Turner, Ming-Qing Du, Shamith A Samarajiwa, Daniel J Hodson
Jul 30, 2021
DDX3X is a ubiquitously expressed RNA helicase involved in multiple stages of RNA biogenesis. DDX3X is frequently mutated in Burkitt lymphoma, but the functional basis for this is unknown. Here, we show that loss-of-function...
Burkitt lymphoma DDX3X Myc RNA helicase Germinal Center proteotoxic stress Translation Adolescent Adult Aged Aged 80 and over Animals B-Lymphocytes Cell Line Tumor Child Child Preschool DEAD-box RNA Helicases Endoplasmic reticulum stress Female Gene Expression Regulation Enzymologic Gene Expression Regulation Neoplastic Humans Loss of Function Mutation Lymphoma B-Cell Male Mice Transgenic Middle Aged Minor Histocompatibility Antigens Neoplasm Proteins Protein Biosynthesis Proteome Proteostasis Proto-Oncogene Proteins c-myc Young Adult
Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer.
Mark R Pickard, Andrew R Green, Ian O Ellis, Carlos Caldas, Vanessa L Hedge, Mirna Mourtada-Maarabouni, Gwyn T Williams
Sep 12, 2011
Adenocarcinoma Apoptosis Breast Neoplasms Cell Line Tumor Epithelial Cells Female Gene Expression Regulation Neoplastic Gene Knockdown Techniques Genetic Association Studies Humans Kaplan-Meier Estimate Neoplasm Proteins Prognosis Protein Serine-Threonine Kinases Proto-Oncogene Proteins c-bcl-2 RNA Interference RNA Small Interfering Ribosomal Proteins Tumor Stem Cell Assay Ultraviolet Rays
P53 autoantibodies in 1006 patients followed up for breast cancer.
Adult Aged Antineoplastic Combined Chemotherapy Protocols Autoantibodies Autoantigens Breast Neoplasms Chemotherapy Adjuvant Clinical Trials as Topic Cohort Studies Disease Progression Enzyme-Linked Immunosorbent Assay Female Follow-Up Studies Humans Mastectomy Menopause Middle Aged Neoplasm Proteins Tamoxifen Treatment Outcome Tumor Suppressor Protein p53
Metabolic synthetic lethality in cancer therapy
Antimetabolites Antineoplastic Computer Simulation Energy Metabolism Forecasting Gene Dosage Gene Silencing Genes Neoplasm Humans Metabolome Mitochondria Mitochondrial Proteins Models Biological Molecular Targeted Therapy Neoplasm Proteins Neoplasms Oncogenes Oxidative Phosphorylation RNA Interference Synthetic Lethal Mutations
Identification of novel epithelial ovarian cancer loci in women of African ancestry.
Ani Manichaikul, Lauren C Peres, Xin-Qun Wang, Mollie E Barnard, Deanna Chyn, Xin Sheng, Zhaohui Du, Jonathan Tyrer, Joseph Dennis, Ann G Schwartz, Michele L Cote, Edward Peters, Patricia G Moorman, Melissa Bondy, Jill S Barnholtz-Sloan, Paul Terry, Anthony J Alberg, Elisa V Bandera, Ellen Funkhouser, Anna H Wu, Celeste Leigh Pearce, Malcom Pike, Veronica Wendy Setiawan, Christopher A Haiman, African American Breast Cancer Consortium (AABC), African Ancestry Prostate Cancer Consortium (AAPC), Julie R Palmer, Loic Lemarchand, Lynne R Wilkens, Andrew Berchuck, Jennifer A Doherty, Francesmary Modugno, Roberta Ness, Kirsten Moysich, Beth Y Karlan, Alice S Whittemore, Valerie McGuire, Weiva Sieh, Kate Lawrenson, Simon Gayther, Thomas A Sellers, Paul Pharoah, Joellen M Schildkraut, African American Cancer Epidemiology Study (AACES) and the Ovarian Cancer Association Consortium (OCAC)
Aug 20, 2019
Women of African ancestry have lower incidence of epithelial ovarian cancer (EOC) yet worse survival compared to women of European ancestry. We conducted a genome-wide association study in African ancestry women with 755 EOC...
African ancestry eQTLs Gene Expression Genome wide association study ovarian cancer Black or African American Aldo-Keto Reductase Family 1 Member C3 Antigens Neoplasm Black People Breast Neoplasms Carcinoma Ovarian Epithelial Female Follistatin Genetic Predisposition to Disease Genome-Wide Association Study Humans Neoplasm Proteins Polymorphism Single Nucleotide United States White People
Regulation of Human γδ T Cells by BTN3A1 Protein Stability and ATP-Binding Cassette Transporters
DA Rhodes, Hung-Chang Chen, James C Williamson, Alfred Hill, Jack Yuan, Sam Smith, Harriet Rhodes, John Trowsdale, Paul J Lehner, Thomas Herrmann, Matthias Eberl
Jul 04, 2018
Activation of human Vγ9/Vδ2 T cells by ‘phosphoantigens’ (pAg), the microbial metabolite (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP) and the endogenous isoprenoid intermediate isopentenyl pyrophosphate (IPP)...
1 Underpinning research 1.1 Normal biological development and functioning 2.1 Biological and endogenous factors 2 Aetiology Generic Health Relevance ATP Binding Cassette Transporter 1 ATP Binding Cassette Transporter Subfamily G Member 1 ATP Binding Cassette Transporter Subfamily G Member 2 Antigen Presentation Antigens CD Butyrophilins Diphosphates HLA Antigens HeLa Cells Humans Interferon-gamma Lymphocyte Activation Neoplasm Proteins Protein Stability Receptors Antigen T-Cell gamma-delta T-Lymphocytes
Cell biology
David C Rubinsztein
Jun 17, 2015
This is the author accepted manuscript. The final version is available from Nature at http://www.nature.com/nature/journal/vaop/ncurrent/full/nature14532.html.
Role and expression of FRS2 and FRS3 in prostate cancer.
Tania Valencia, Ajay Joseph, Naveen Kachroo, Steve Darby, Susan Meakin, Vincent J Gnanapragasam
Dec 06, 2011
Differential expression of selected histone modifier genes in human solid cancers.
Hilal Ozdağ, Andrew E Teschendorff, Ahmed Ashour Ahmed, Sarah J Hyland, Cherie Blenkiron, Linda Bobrow, Abhi Veerakumarasivam, Glynn Burtt, Tanya Subkhankulova, Mark J Arends, V Peter Collins, David Bowtell, Tony Kouzarides, James D Brenton, Carlos Caldas
Jun 14, 2011
Breast Neoplasms Carcinoma Cell Transformation Neoplastic Cluster Analysis Colorectal Neoplasms DNA Complementary DNA Neoplasm Female Gene Expression Regulation Enzymologic Gene Expression Regulation Neoplastic Histone Acetyltransferases Histone Code Histone Deacetylases Histone Methyltransferases Histone-Lysine N-Methyltransferase Histones Humans Linear Models Lung Neoplasms Male Neoplasm Proteins Neoplasms Ovarian Neoplasms Pancreatic Neoplasms Polymerase Chain Reaction Polymorphism Single-Stranded Conformational Protein Methyltransferases Protein Processing Post-Translational
Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome.
Felix R Day, David A Hinds, Joyce Y Tung, Lisette Stolk, Unnur Styrkarsdottir, Richa Saxena, Andrew Bjonnes, Linda Broer, David B Dunger, Bjarni V Halldorsson, Debbie A Lawlor, Guillaume Laval, Iain Mathieson, Wendy L McCardle, Yvonne Louwers, Cindy Meun, Susan Ring, Robert A Scott, Patrick Sulem, André G Uitterlinden, Nicholas J Wareham, Unnur Thorsteinsdottir, Corrine Welt, Kari Stefansson, Joop SE Laven, Ken K Ong, John RB Perry
Aug 04, 2015
Acid Anhydride Hydrolases Adaptor Proteins Signal Transducing aging Case-Control Studies DNA Repair Enzymes DNA-Binding Proteins ErbB Receptors Female Follicle Stimulating Hormone beta Subunit Genome-Wide Association Study Humans Neoplasm Proteins Ovary Phosphoproteins POLYCYSTIC OVARY SYNDROME selection Genetic Transcription Factors White People YAP-Signaling Proteins
The Autophagy Receptor TAX1BP1 and the Molecular Motor Myosin VI Are Required for Clearance of Salmonella Typhimurium by Autophagy.
David A Tumbarello, Paul T Manna, Mark Allen, Mark Bycroft, Susan D Arden, John Kendrick-Jones, Folma Buss
Oct 13, 2015
Animals Autophagy Blotting Western Cells Cultured Gene Knockdown Techniques HeLa Cells Humans Immunoprecipitation Intracellular Signaling Peptides and Proteins Magnetic Resonance Spectroscopy Mice Microscopy Fluorescence Molecular Sequence Data Myosin Heavy Chains Neoplasm Proteins Phylogeny Protein Conformation Salmonella Infections Salmonella typhimurium Ubiquitination
An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid.
Marc de la Roche, Trevor J Rutherford, Deepti Gupta, Dmitry B Veprintsev, Barbara Saxty, Stefan M Freund, Mariann Bienz
Apr 03, 2019
Wnt/β-catenin signalling controls development and tissue homeostasis. Moreover, activated β-catenin can be oncogenic and, notably, drives colorectal cancer. Inhibiting oncogenic β-catenin has proven a formidable challenge. Here...
Abietanes Binding Sites Cell Line Tumor Colorectal Neoplasms Crystallography X-Ray HEK293 Cells HeLa Cells Humans Neoplasm Proteins Nuclear Magnetic Resonance Biomolecular Plant Extracts Proteasome Endopeptidase Complex Protein Stability Rosmarinus Signal Transduction Transcription Factors Wnt Proteins beta Catenin
Accounting for the Multiple Natures of Missing Values in Label-Free Quantitative Proteomics Data Sets to Compare Imputation Strategies.
Genomic structure and transcript analysis of the Rapid Alkalinization Factor (RALF) gene family during host-pathogen crosstalk in Fragaria vesca and Fragaria x ananassa strawberry.
Rapid Alkalinization Factors (RALFs) are cysteine-rich peptides ubiquitous within plant kingdom. They play multiple roles as hormonal signals in diverse processes, including root elongation, cell growth, pollen tube development...
The use of automated quantitative analysis to evaluate epithelial-to-mesenchymal transition associated proteins in clear cell renal cell carcinoma.
Fiach C O'Mahony, Dana Faratian, James Varley, Jyoti Nanda, Marianna Theodoulou, Antony CP Riddick, David J Harrison, Grant D Stewart
May 14, 2020
BACKGROUND: Epithelial-to-mesenchymal transition (EMT) has recently been implicated in the initiation and progression of renal cell carcinoma (RCC). Some mRNA gene expression studies have suggested a link between the EMT...
Adult Aged Aged 80 and over Antibodies Neoplasm Automation Carcinoma Renal Cell Cluster Analysis Databases Genetic Disease-Free Survival Epithelial-Mesenchymal Transition Female Fluorescent Antibody Technique Gene Expression Regulation Neoplastic Humans Kidney Neoplasms Male Middle Aged Multivariate Analysis Neoplasm Proteins Oligonucleotide Array Sequence Analysis Phenotype Proportional Hazards Models Reproducibility of Results statistics Nonparametric
The roles of DNA, RNA and histone methylation in ageing and cancer.
Chromatin is a macromolecular complex predominantly comprising DNA, histone proteins and RNA. The methylation of chromatin components is highly conserved as it helps coordinate the regulation of gene expression, DNA repair and...
Evaluation of associations between genetically predicted circulating protein biomarkers and breast cancer risk.
Xiang Shu, Jiandong Bao, Lang Wu, Jirong Long, Xiao-Ou Shu, Xingyi Guo, Yaohua Yang, Kyriaki Michailidou, Manjeet K Bolla, Qin Wang, Joe Dennis, Irene L Andrulis, Jose E Castelao, Thilo Dörk, Manuela Gago-Dominguez, Montserrat García-Closas, Graham G Giles, Artitaya Lophatananon, Kenneth Muir, Håkan Olsson, Gadi Rennert, Emmanouil Saloustros, Rodney J Scott, Melissa C Southey, Paul DP Pharoah, Roger L Milne, Peter Kraft, Jacques Simard, Douglas F Easton, Wei Zheng
Jun 19, 2019
RNA G-quadruplexes at upstream open reading frames cause DHX36- and DHX9-dependent translation of human mRNAs.
Pierre Murat, Giovanni Marsico, Barbara Herdy, Avazeh T Ghanbarian, Guillem Portella, Shankar Balasubramanian
Jan 07, 2019
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