Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways.
David L Duffy,
Gu Zhu,
Xin Li,
Marianna Sanna,
Mark M Iles,
Leonie C Jacobs,
David M Evans,
Seyhan Yazar,
Jonathan Beesley,
Matthew H Law,
Peter Kraft,
Alessia Visconti,
John C Taylor,
Fan Lui,
Margaret J Wright,
Anjali K Henders,
Lisa Bowdler,
Dan Glass,
Arfan M Ikram,
André G Uitterlinden,
Pamela A Madden,
Andrew C Heath,
Elliot C Nelson,
Adele C Green,
Stephen Chanock,
Jennifer H Barrett,
Matthew A Brown,
Nicholas K Hayward,
Stuart MacGregor,
Richard A Sturm,
Alex W Hewitt,
Melanoma GWAS Consortium,
Manfred Kayser,
David J Hunter,
Julia A Newton Bishop,
Timothy D Spector,
Grant W Montgomery,
David A Mackey,
George Davey Smith,
Tamar E Nijsten,
D Timothy Bishop,
Veronique Bataille,
Mario Falchi,
Jiali Han,
Nicholas G Martin
Jan 31, 2019
The total number of acquired melanocytic nevi on the skin is strongly correlated with melanoma risk. Here we report a meta-analysis of 11 nevus GWAS from Australia, Netherlands, UK, and USA comprising 52,506 individuals. We...