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Cell competition
DD Cell division producing 2 differentiated cells DN-Maml1 Dominant negative mutant of Mastermind like 1 EE Esophageal Epithelium EYFP Enhanced Yellow Fluorescent Protein GFP green fluorescent protein Nicd Notch Cytoplasmic Domain PD Cell division producing one progenitor and one differentiating cell PP Cell division producing 2 progenitor cells Cancer Carcinogenesis esophagus field change progenitor Squamous stem cell Animals Cell Differentiation DNA-Binding Proteins Epithelial Cells Esophagus Mice Mutation Nuclear Proteins Receptors Notch Signal Transduction Transcription Factors Tumor Suppressor Protein p53
Modulation of basal cell fate during productive and transforming HPV-16 infection is mediated by progressive E6-driven depletion of Notch
In stratified epithelia such as the epidermis, homeostasis is maintained by the proliferation of cells in the lower epithelial layers and the concomitant loss of differentiated cells from the epithelial surface. These...