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Results: 5
Activin/nodal signaling and NANOG orchestrate human embryonic stem cell fate decisions by controlling the H3K4me3 chromatin mark.
Alessandro Bertero, Pedro Madrigal, Antonella Galli, Nina C Hubner, Inmaculada Moreno, Deborah Burks, Stephanie Brown, Roger A Pedersen, Daniel Gaffney, Sasha Mendjan, Siim Pauklin, Ludovic Vallier
May 21, 2015
Activin/Nodal DPY30 H3K4me3 NANOG SMAD2/3 hESCs Activins Animals Cell Differentiation Cells Cultured Chromatin Embryo Mammalian Embryonic Stem Cells Epigenesis Genetic Histone Methyltransferases Histone-Lysine N-Methyltransferase Histones Homeodomain Proteins Humans Mice Nanog Homeobox Protein Nodal Protein Signal Transduction Smad2 Protein Smad3 Protein
A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre.
Matteo A Molè, Tim HH Coorens, Marta N Shahbazi, Antonia Weberling, Bailey AT Weatherbee, Carlos W Gantner, Carmen Sancho-Serra, Lucy Richardson, Abbie Drinkwater, Najma Syed, Stephanie Engley, Philip Snell, Leila Christie, Kay Elder, Alison Campbell, Simon Fishel, Sam Behjati, Roser Vento-Tormo, Magdalena Zernicka-Goetz
May 13, 2021
Bone Morphogenetic Protein 1 Cell Lineage Cells Cultured Embryo Implantation Embryo Mammalian Embryonic Development Fibroblast Growth Factors Gastrulation Gene Expression Regulation Developmental Germ Layers Humans Image Processing Computer-Assisted Multigene Family Nodal Protein RNA-seq Single-Cell Analysis Spatio-Temporal Analysis Wnt Signaling Pathway
A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre.
Matteo A Molè, Tim H H Coorens, Marta N Shahbazi, Antonia Weberling, Bailey A T Weatherbee, Carlos W Gantner, Carmen Sancho-Serra, Lucy Richardson, Abbie Drinkwater, Najma Syed, Stephanie Engley, Philip Snell, Leila Christie, Kay Elder, Alison Campbell, Simon Fishel, Sam Behjati, Roser Vento-Tormo, Magdalena Zernicka-Goetz
Jul 28, 2021
Following implantation, the human embryo undergoes major morphogenetic transformations that establish the future body plan. While the molecular events underpinning this process are established in mice, they remain unknown in...
Cells Cultured Germ Layers Humans Fibroblast Growth Factors Gene Expression Regulation Developmental Cell Lineage Embryonic Development Embryo Implantation Multigene Family Image Processing Computer-Assisted Embryo Mammalian Gastrulation Bone Morphogenetic Protein 1 Nodal Protein Single-Cell Analysis Wnt Signaling Pathway Spatio-Temporal Analysis RNA-seq
Published by: Nature Communications
The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency.
Alessandro Bertero, Stephanie Brown, Pedro Madrigal, Anna Osnato, Daniel Ortmann, Loukia Yiangou, Juned Kadiwala, Nina C Hubner, Igor Ruiz de Los Mozos, Christoph Sadée, An-Sofie Lenaerts, Shota Nakanoh, Rodrigo Grandy, Edward Farnell, Jernej Ule, Hendrik G Stunnenberg, Sasha Mendjan, Ludovic Vallier
May 15, 2018
Activins Adenosine Animals Cell Cycle Proteins Cell Differentiation Epigenesis Genetic Humans Methylation Methyltransferases Multiprotein Complexes Nanog Homeobox Protein Nodal Protein Nuclear Proteins Pluripotent Stem Cells Protein Binding RNA Splicing Factors RNA Messenger Signal Transduction Smad2 Protein Smad3 Protein Transcriptome Transforming Growth Factor beta