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Despite their abundance, mid-sized RNAs (30-300 nt) have not been extensively studied by high-throughput sequencing, mostly due to selective loss in library preparation. The authors propose simple and inexpensive modifications...

Reports 5′ coverage high-throughput sequencing next-generation sequencing Non-coding RNA size-selection

Bioinformatics small RNA DICER small-interfering RNA Non-coding RNA RNA processing

Protein aggregation is associated with age-related neurodegenerative disorders, such as Alzheimer's and polyglutamine diseases. As a causal relationship between protein aggregation and neurodegeneration remains elusive...

C. elegans MOAG-2/LIR-3 RNA Polymerase III Non-coding RNA polyglutamine protein aggregation Protein homeostasis protein quality control snoRNA tRNA Active Transport Cell Nucleus Animals Animals Genetically Modified Binding Sites Caenorhabditis elegans Caenorhabditis elegans Proteins Cell Nucleus Cytosol Disease Models Animal Neurodegenerative Diseases Peptides Promoter Regions Genetic Protein Aggregates protein aggregation Pathological Protein Binding RNA Interference RNA Polymerase III RNA Small Untranslated Transcription Factors Transcription Genetic

Research on non-coding RNA (ncRNA) is a rapidly expanding field. Providing an official gene symbol and name to ncRNA genes brings order to otherwise potential chaos as it allows unambiguous communication about each gene. The...

Non-coding RNA gene nomenclature gene symbols

article HCMV latency Non-coding RNA Reactive Oxygen Species β2.7

3′ UTR ArcZ Hfq RNA degradome RNase E RprA TIER-seq Non-coding RNA sRNA maturation uridine ruler 3' Untranslated Regions Bacterial Proteins Catalysis Computational Biology Databases Genetic Endoribonucleases Gene Expression Regulation Bacterial Host Factor 1 Protein Molecular Dynamics Simulation Nucleic Acid Conformation RNA Precursors RNA Bacterial RNA Messenger RNA Small Untranslated Salmonella enterica Structure-Activity Relationship Transcriptome Uridine

Despite their abundance, mid-sized RNAs (30-300 nt) have not been extensively studied by high-throughput sequencing, mostly due to selective loss in library preparation. The authors propose simple and inexpensive modifications...

5′ coverage high-throughput sequencing next-generation sequencing Non-coding RNA size-selection Gene Library High-Throughput Nucleotide Sequencing RNA Untranslated RNA-seq Sequence Analysis RNA

Cell Proliferation DNA Replication Non-coding RNA Animals Caenorhabditis elegans Cell Proliferation DNA Replication Embryonic Development RNA Untranslated

Objective markers for the neurodegenerative disorder progressive supranuclear palsy (PSP) are needed to provide a timely diagnosis with greater certainty. Non-coding RNA (ncRNA), including microRNA, piwi-interacting RNA, and...

PSP RNA-seq biomarker Non-coding RNA progressive supranuclear palsy Humans Supranuclear Palsy Progressive Biomarkers MicroRNAs Down-Regulation

DNA replication in the embryo of Xenopus laevis changes dramatically at the mid-blastula transition (MBT), with Y RNA-independent random initiation switching to Y RNA-dependent initiation at specific origins. Here, we identify...

DNA Replication NuRD Xenopus laevis Y RNA chromatin remodeling development Histone deacetylase initiation mid-blastula transition Non-coding RNA Animals Blastula Cell Extracts DNA Replication Embryonic Development HeLa Cells Humans Mi-2 Nucleosome Remodeling and Deacetylase Complex Ovum RNA Xenopus laevis

Research on non-coding RNA (ncRNA) is a rapidly expanding field. Providing an official gene symbol and name to ncRNA genes brings order to otherwise potential chaos as it allows unambiguous communication about each gene. The...

gene nomenclature gene symbols Non-coding RNA Genome Human Humans RNA Untranslated Terminology as Topic

article progressive supranuclear palsy PSP biomarker Non-coding RNA RNA-seq

Y RNAs (84-112 nt) are non-coding RNAs transcribed by RNA polymerase III and are characterized by a distinctive secondary structure. Human Y RNAs interact with the autoimmune proteins SSB and RO60 that together form a...

Y RNA Apoptosis Cancer Non-coding RNA small RNA Animals FIBROBLASTS Mice Nucleic Acid Conformation RNA processing Post-Transcriptional RNA Untranslated Ribonucleoproteins

DNA Replication Non-coding RNA RNA domains RNA Stability Y RNA Animals Base Sequence DNA Replication Humans Models Molecular Molecular Sequence Data Nucleic Acid Conformation RNA Untranslated Ribonucleoproteins

The enzyme Dicer is a component of many small RNA (sRNA) pathways involved in RNA processing for post-transcriptional regulation, anti-viral response and control of transposable elements. Cleavage of double-stranded RNA by Dicer...

DICER RNA processing Non-coding RNA small RNA small-interfering RNA

Human cytomegalovirus (HCMV) is a significant source of disease for the immunosuppressed and immunonaive. The treatment of HCMV is made more problematic by viral latency, a lifecycle stage in which the virus reduces its...

HCMV latency Non-coding RNA Reactive Oxygen Species β2.7 antioxidants Cytomegalovirus Gene Silencing Humans NF-kappa B RNA Long Noncoding Reactive Oxygen Species Virus Latency

AFRICAN TRYPANOSOMIASIS RET1 RNA modifications TUTase drug-discovery Non-coding RNA post-transcriptional modification trypanosome uridylylation Drug Discovery Humans Nucleic Acid Synthesis Inhibitors Protozoan Proteins RNA Editing RNA Nucleotidyltransferases RNA Untranslated Trypanocidal Agents Trypanosoma brucei brucei Trypanosomiasis African Uridine Triphosphate