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Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer.
Zhi Hu, Jian-Hua Mao, Christina Curtis, Ge Huang, Shenda Gu, Laura Heiser, Marc E Lenburg, James E Korkola, Nora Bayani, Shamith Samarajiwa, Jose A Seoane, Mark A Dane, Amanda Esch, Heidi S Feiler, Nicholas J Wang, Mary Ann Hardwicke, Sylvie Laquerre, Jeff Jackson, Kenneth W Wood, Barbara Weber, Paul T Spellman, Samuel Aparicio, Richard Wooster, Carlos Caldas, Joe W Gray
Oct 18, 2018
BACKGROUND: High mitotic activity is associated with the genesis and progression of many cancers. Small molecule inhibitors of mitotic apparatus proteins are now being developed and evaluated clinically as anticancer agents....
Breast Cancer Mitotic Index Novel therapeutics Predictive biomarker Aurora Kinases Breast Neoplasms Cell Cycle Proteins Cell Line Tumor Cell Proliferation Chromosomal Proteins Non-Histone Female Gene Amplification Gene Expression Profiling Gene Expression Regulation Neoplastic Gene Regulatory Networks Genome Human Humans Kaplan-Meier Estimate Mitosis Prognosis Protein Serine-Threonine Kinases Proto-Oncogene Proteins RNA Interference Small Molecule Libraries Treatment Outcome