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Results: 16
Improvement over time in outcomes for patients undergoing endoscopic therapy for Barrett's oesophagus-related neoplasia
RJ Haidry, MA Butt, JM Dunn, A Gupta, G Lipman, HL Smart, P Bhandari, L Smith, R Willert, G Fullarton, M di Pietro, C Gordon, I Penman, H Barr, P Patel, N Kapoor, J Hoare, R Narayanasamy, Y Ang, A Veitch, K Ragunath, M Novelli, LB Lovat, UK RFA Registry
Aug 20, 2020
BACKGROUND: Barrett's oesophagus (BE) is a pre-malignant condition leading to oesophageal adenocarcinoma (OAC). Treatment of neoplasia at an early stage is desirable. Combined endoscopic mucosal resection (EMR) followed by...
BARRETT'S OESOPHAGUS ENDOSCOPIC PROCEDURES OESOPHAGEAL CANCER Adenocarcinoma Adult Aged Aged 80 and over Barrett Esophagus Catheter Ablation Disease Progression Esophageal Neoplasms Esophagoscopy Female Follow-Up Studies Humans Male Middle Aged Precancerous Conditions Prospective Studies Registries Time Factors Treatment Outcome United Kingdom
Impact of Barrett oesophagus diagnoses and endoscopies on oesophageal cancer survival in the UK
BACKGROUND: Current guidelines recommend endoscopic surveillance for Barrett oesophagus (BE), but the value of surveillance is still debated. Using a combination of primary care, secondary care and cancer registry datasets, we...
Barrett's oESophagus trial 3 (BEST3)
Judith Offman, Beth Muldrew, Maria O'Donovan, Irene Debiram-Beecham, Francesca Pesola, Irene Kaimi, Samuel G Smith, Ashley Wilson, Zohrah Khan, Pierre Lao-Sirieix, Benoit Aigret, Fiona M Walter, Greg Rubin, Steve Morris, Christopher Jackson, Peter Sasieni, Rebecca C Fitzgerald, BEST3 Trial team
Sep 29, 2018
Acceptability Acid reflux biomarker cost effectiveness Early detection endoscopy Heartburn Medical device OESOPHAGEAL CANCER Quality of life Barrett Esophagus Chronic Disease Disease Progression Early Detection of Cancer endoscopy Digestive System Equipment Design Esophageal Neoplasms Female Gastroesophageal Reflux Humans Male Middle Aged Primary Health Care
Hnf4α is a key gene that can generate columnar metaplasia in oesophageal epithelium
Benjamin J. Colleypriest, Zoë D. Burke, Leonard P. Griffiths, Yu Chen, Wei-Yuan Yu, Ramiro Jover, Michael Bock, Leigh Biddlestone, Jonathan M. Quinlan, Stephen G. Ward, J. Mark Farrant, Jonathan M W Slack, David Tosh
Jan 01, 2017
Barrett's metaplasia is the only known morphological precursor to oesophageal adenocarcinoma and is characterized by replacement of stratified squamous epithelium by columnar epithelium. The cell of origin is uncertain and...
Immune activation by DNA damage predicts response to chemotherapy and survival in oesophageal adenocarcinoma.
Richard C Turkington, Laura A Knight, Jaine K Blayney, Maria Secrier, Rosalie Douglas, Eileen E Parkes, Eilis K Sutton, Leanne Stevenson, Damian McManus, Sophia Halliday, Andrena M McCavigan, Gemma E Logan, Steven M Walker, Christopher J Steele, Juliane Perner, Jan Bornschein, Shona MacRae, Ahmad Miremadi, Eamon McCarron, Stephen McQuaid, Kenneth Arthur, Jacqueline A James, Martin M Eatock, Robert O'Neill, Fergus Noble, Timothy J Underwood, D Paul Harkin, Manuel Salto-Tellez, Rebecca C Fitzgerald, Richard D Kennedy, Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Study Group
Sep 25, 2019
EGFR amplification and outcome in a randomised phase III trial of chemotherapy alone or chemotherapy plus panitumumab for advanced gastro-oesophageal cancers.
Elizabeth C Smyth, Georgios Vlachogiannis, Somaieh Hedayat, Alice Harbery, Sanna Hulkki-Wilson, Massimiliano Salati, Kyriakos Kouvelakis, Javier Fernandez-Mateos, George D Cresswell, Elisa Fontana, Therese Seidlitz, Clare Peckitt, Jens C Hahne, Andrea Lampis, Ruwaida Begum, David Watkins, Sheela Rao, Naureen Starling, Tom Waddell, Alicia Okines, Tom Crosby, Was Mansoor, Jonathan Wadsley, Gary Middleton, Matteo Fassan, Andrew Wotherspoon, Chiara Braconi, Ian Chau, Igor Vivanco, Andrea Sottoriva, Daniel E Stange, David Cunningham, Nicola Valeri
Nov 11, 2020
Gastric adenocarcinoma gastrointestinal cancer molecular oncology OESOPHAGEAL CANCER Adenocarcinoma Aged Antibiotics Antineoplastic Antineoplastic Agents Immunological Antineoplastic Combined Chemotherapy Protocols Biomarkers Tumor Epirubicin ErbB Receptors Esophageal Neoplasms Humans Male Middle Aged Panitumumab Stomach Neoplasms
The combination of autofluorescence endoscopy and molecular biomarkers is a novel diagnostic tool for dysplasia in Barrett's oesophagus.
Massimiliano di Pietro, David F Boerwinkel, Mohammed Kareem Shariff, Xinxue Liu, Emmanouil Telakis, Pierre Lao-Sirieix, Elaine Walker, George Couch, Leanne Mills, Tara Nuckcheddy-Grant, Susan Slininger, Maria O'Donovan, Mike Visser, Sybren L Meijer, Philip V Kaye, Lorenz Wernisch, Krish Ragunath, Jacques JGHM Bergman, Rebecca C Fitzgerald
Feb 13, 2020
OBJECTIVE: Endoscopic surveillance for Barrett's oesophagus (BO) is limited by sampling error and the subjectivity of diagnosing dysplasia. We aimed to compare a biomarker panel on minimal biopsies directed by autofluorescence...
British Society of Gastroenterology guidelines on the diagnosis and management of Barrett's oesophagus.
Rebecca C Fitzgerald, Massimiliano di Pietro, Krish Ragunath, Yeng Ang, Jin-Yong Kang, Peter Watson, Nigel Trudgill, Praful Patel, Philip V Kaye, Scott Sanders, Maria O'Donovan, Elizabeth Bird-Lieberman, Pradeep Bhandari, Janusz A Jankowski, Stephen Attwood, Simon L Parsons, Duncan Loft, Jesper Lagergren, Paul Moayyedi, Georgios Lyratzopoulos, John de Caestecker, British Society of Gastroenterology
Sep 05, 2018
These guidelines provide a practical and evidence-based resource for the management of patients with Barrett's oesophagus and related early neoplasia. The Appraisal of Guidelines for Research and Evaluation (AGREE II) instrument...
BARRETT'S CARCINOMA BARRETT'S METAPLASIA BARRETT'S OESOPHAGUS gastroesophageal reflux disease OESOPHAGEAL CANCER Ablation Techniques Adenocarcinoma Barrett Esophagus Biopsy Cost-Benefit Analysis Decision Support Techniques Early Detection of Cancer Esophageal Neoplasms Esophagectomy Esophagoscopy esophagus Humans Risk Assessment Risk Factors United Kingdom United States
Hnf4α is a key gene that can generate columnar metaplasia in oesophageal epithelium
Benjamin J. Colleypriest, Zoë D. Burke, Leonard P. Griffiths, Yu Chen, Wei-Yuan Yu, Ramiro Jover, Michael Bock, Leigh Biddlestone, Jonathan M. Quinlan, Stephen G. Ward, J. Mark Farrant, Jonathan M W Slack, David Tosh
Jan 01, 2017
Barrett's metaplasia is the only known morphological precursor to oesophageal adenocarcinoma and is characterized by replacement of stratified squamous epithelium by columnar epithelium. The cell of origin is uncertain and...
Timeline and location of recurrence following successful ablation in Barrett's oesophagus
Sarmed S Sami, Adharsh Ravindran, Allon Kahn, Diana Snyder, Jose Santiago, Jacobo Ortiz-Fernandez-Sordo, Wei Keith Tan, Ross A Dierkhising, Julia E Crook, Michael G Heckman, Michele L Johnson, Ramona Lansing, Krish Ragunath, Massimiliano di Pietro, Herbert Wolfsen, Francisco Ramirez, David Fleischer, Kenneth K Wang, Cadman L Leggett, David A Katzka, Prasad G Iyer
Aug 14, 2020
OBJECTIVE: Surveillance interval protocols after complete remission of intestinal metaplasia (CRIM) post radiofrequency ablation (RFA) in Barrett's oesophagus (BE) are currently empiric and not based on substantial evidence. We...
Barrett’s oesophagus ENDOSCOPIC PROCEDURES OESOPHAGEAL CANCER Adenocarcinoma Aged Barrett Esophagus Biopsy Catheter Ablation Cohort Studies Disease Progression Esophageal Neoplasms Esophagogastric Junction Esophagoscopy esophagus Female Humans Male Metaplasia Middle Aged Neoplasm Recurrence Local Precancerous Conditions Risk Assessment United Kingdom United States
The human squamous oesophagus has widespread capacity for clonal expansion from cells at diverse stages of differentiation.
Mariagnese Barbera, Massimiliano di Pietro, Elaine Walker, Charlotte Brierley, Shona MacRae, Benjamin D Simons, Phil H Jones, John Stingl, Rebecca C Fitzgerald
Feb 13, 2020
OBJECTIVE: Knowledge of the cellular mechanisms involved in homeostasis of human squamous oesophagus in the steady state and following chronic injury is limited. We aimed to better understand these mechanisms by using a...
The SYMPTOM-upper gastrointestinal study
Napin Karnchanachari, Shakira Milton, Tjuntu Muhlen-Schulte, Riati Scarborough, Jennifer F Holland, Fiona M Walter, John Zalcberg, Jon Emery
May 09, 2022
OBJECTIVE: There is limited evidence on the development of pancreatic and oesophagogastric cancer, how patients decide to seek help and the factors impacting help-seeking. Our study, the first in Australia, aimed to explore...
Early detection and therapeutics.
Early detection, including cancer screening and surveillance, is emerging as one of the most important topics in modern oncology. Because symptomatic presentation remains the predominant route to cancer diagnosis, there is a...
Germline variation in inflammation-related pathways and risk of Barrett's oesophagus and oesophageal adenocarcinoma.
Matthew F Buas, Qianchuan He, Lisa G Johnson, Lynn Onstad, David M Levine, Aaron P Thrift, Puya Gharahkhani, Claire Palles, Jesper Lagergren, Rebecca C Fitzgerald, Weimin Ye, Carlos Caldas, Nigel C Bird, Nicholas J Shaheen, Leslie Bernstein, Marilie D Gammon, Anna H Wu, Laura J Hardie, Paul D Pharoah, Geoffrey Liu, Prassad Iyer, Douglas A Corley, Harvey A Risch, Wong-Ho Chow, Hans Prenen, Laura Chegwidden, Sharon Love, Stephen Attwood, Paul Moayyedi, David MacDonald, Rebecca Harrison, Peter Watson, Hugh Barr, John deCaestecker, Ian Tomlinson, Janusz Jankowski, David C Whiteman, Stuart MacGregor, Thomas L Vaughan, Margaret M Madeleine
Aug 16, 2016
BARRETT'S OESOPHAGUS GENETIC POLYMORPHISMS Inflammation OESOPHAGEAL CANCER Adenocarcinoma Aged Barrett Esophagus Cytokines Esophageal Neoplasms Female Gene-Environment Interaction Genetic Predisposition to Disease Genome-Wide Association Study Germ-Line Mutation Glutathione Transferase HLA Antigens Humans Inflammation Male Middle Aged NF-kappa B Oxidative Stress Polymorphism Single Nucleotide principal component analysis Prostaglandin-Endoperoxide Synthases Risk Factors Signal Transduction
Revised British Society of Gastroenterology recommendation on the diagnosis and management of Barrett's oesophagus with low-grade dysplasia.
The most recent guidelines for the management of Barrett's oesophagus published in 2014 recommended endoscopic surveillance for patient with histological evidence of low-grade dysplasia (LGD) on random biopsies.1 In the last...
Glucose transporter 1 expression as a marker of prognosis in oesophageal adenocarcinoma.
Jaine K Blayney, Lauren Cairns, Gerald Li, Niamh McCabe, Leanne Stevenson, Christopher J Peters, Nathan B Reid, Veronica J Spence, Chintapuza Chisambo, Damian McManus, Jacqueline James, Stephen McQuaid, Stephanie Craig, Kenneth Arthur, Darragh McArt, Chin-Ann J Ong, Pierre Lao-Sirieix, Peter Hamilton, Manuel Salto-Tellez, Martin Eatock, Helen G Coleman, Rebecca C Fitzgerald, Richard D Kennedy, Richard C Turkington, Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Study Group
Dec 16, 2019
BACKGROUND: The current TNM staging system for oesophageal adenocarcinoma (OAC) has limited ability to stratify patients and inform clinical management following neo-adjuvant chemotherapy and surgery. RESULTS: Functional genomic...