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Results: 46
Delivery and impact of the NHS Health Check in the first 8 years
Adam Martin, Catherine L Saunders, Emma Harte, Simon J Griffin, Calum MacLure, Jonathan Mant, Catherine Meads, Fiona M Walter, Juliet A Usher-Smith
May 02, 2018
BACKGROUND: Since 2009, all eligible persons in England have been entitled to an NHS Health Check. Uncertainty remains about who attends, and the health-related impacts. AIM: To review quantitative evidence on coverage (the...
Humans Cardiovascular Diseases Diabetes mellitus Program Evaluation Health Promotion Preventive Health Services National Health Programs State Medicine Delivery of Health Care Patient Acceptance of Health Care Evaluation Studies as Topic Quality Improvement Observational Studies as Topic United Kingdom
Refractory lupus nephritis
Andreas Kronbichler, Biljana Brezina, Philipp Gauckler, Luis F Quintana, David RW Jayne
May 13, 2019
Refractory lupus nephritis indicates an inadequate response to lupus nephritis therapy. It implies persisting or worsening disease activity despite therapy, but the definition is complicated by the parameters of response...
Stromal-driven and Amyloid β-dependent induction of neutrophil extracellular traps modulates tumor growth.
Hafsa Munir, James O Jones, Tobias Janowitz, Markus Hoffmann, Maximilien Euler, Carla P Martins, Sarah J Welsh, Jacqueline D Shields
Jan 05, 2021
Tumors consist of cancer cells and a network of non-cancerous stroma. Cancer-associated fibroblasts (CAF) are known to support tumorigenesis, and are emerging as immune modulators. Neutrophils release histone-bound nuclear DNA...
Amyloid Precursor Protein Secretases Amyloid beta-Peptides Animals Bone Marrow CD11b Antigen Cancer-Associated Fibroblasts Carcinogenesis Cell Communication Disease Models Animal Extracellular Traps Female Healthy Volunteers Humans Male Mice Mice Transgenic Neoplasms Neutrophils Observational Studies as Topic Primary Cell Culture Prognosis Protein-Arginine Deiminase Type 4 Reactive Oxygen Species Tumor Cells Cultured Tumor Microenvironment
Evidence-based prevention of Alzheimer's disease
Jin-Tai Yu, Wei Xu, Chen-Chen Tan, Sandrine Andrieu, John Suckling, Evangelos Evangelou, An Pan, Can Zhang, Jianping Jia, Lei Feng, Ee-Heok Kua, Yan-Jiang Wang, Hui-Fu Wang, Meng-Shan Tan, Jie-Qiong Li, Xiao-He Hou, Yu Wan, Lin Tan, Vincent Mok, Lan Tan, Qiang Dong, Jacques Touchon, Serge Gauthier, Paul S Aisen, Bruno Vellas
Aug 06, 2020
BACKGROUND: Evidence on preventing Alzheimer's disease (AD) is challenging to interpret due to varying study designs with heterogeneous endpoints and credibility. We completed a systematic review and meta-analysis of current...
Alzheimer's Disease EPIDEMIOLOGY Meta-Analysis systematic reviews Alzheimer Disease Antihypertensive Agents Cognition Craniocerebral Trauma Depression Diabetes mellitus Education Evidence-Based Medicine Exercise Humans Hyperhomocysteinemia Hypertension Hypotension Orthostatic Life Style obesity Observational Studies as Topic Randomized Controlled Trials as Topic Risk Reduction Behavior Stress Psychological
Outcome-sensitive multiple imputation
BACKGROUND: Multiple imputation is frequently used to deal with missing data in healthcare research. Although it is known that the outcome should be included in the imputation model when imputing missing covariate values, it is...
MesoTRAP
Claire Matthews, Carol Freeman, Linda D Sharples, Julia Fox-Rushby, Angela Tod, Nicholas A Maskell, John G Edwards, Aman S Coonar, Pasupathy Sivasothy, Victoria Hughes, Najib M Rahman, David A Waller, Robert Campbell Rintoul
Apr 05, 2019
INTRODUCTION: One of the most debilitating symptoms of malignant pleural mesothelioma (MPM) is dyspnoea caused by pleural effusion. MPM can be complicated by the presence of tumour on the visceral pleura preventing the lung from...
Asbestos Induced Lung Disease Mesothelioma Pleural Disease Thoracic Surgery Adult Catheters Indwelling Clinical Trials Phase III as Topic England Feasibility Studies Female Humans Lung Neoplasms Male Mesothelioma Mesothelioma Malignant Multicenter Studies as Topic Observational Studies as Topic Pilot Projects Pleural Effusion Malignant Pleural Neoplasms Pleurodesis Randomized Controlled Trials as Topic Sample Size Survival Analysis Thoracic Surgery Video-Assisted Treatment Outcome
Survival time and differences between dementia with Lewy bodies and Alzheimer's disease following diagnosis
Christoph Mueller, Pinar Soysal, Arvid Rongve, Ahmet Turan Isik, Trevor Thompson, Stefania Maggi, Lee Smith, Cristina Basso, Robert Stewart, Clive Ballard, John T O'Brien, Dag Aarsland, Brendon Stubbs, Nicola Veronese
Feb 07, 2019
Clinical laboratory parameters associated with severe or critical novel coronavirus disease 2019 (COVID-19)
Jude Moutchia, Pratik Pokharel, Aldiona Kerri, Kaodi McGaw, Shreeshti Uchai, Miriam Nji, Michael Goodman
Oct 01, 2020
Studying Trends of Auto-Regulation in Severe Head Injury in Paediatrics (STARSHIP)
Shruti Agrawal, Michal M Placek, Deborah White, Esther Daubney, Manuel Cabeleira, Peter Smielewski, Marek Czosnyka, Adam Young, Suzanna Watson, Anna Maw, Peter John Hutchinson
Apr 11, 2023
Introduction
Studying cerebral autoregulation, particularly PRx (Pressure Reactivity Index), is commonly employed in adult traumatic brain injury (TBI) and gives real-time information about intracranial pathophysiology...
Physiology TRAUMA MANAGEMENT neurological injury paediatric intensive & critical care Humans Prospective Studies Homeostasis Cerebrovascular Circulation Intracranial Pressure Adult Child Multicenter Studies as Topic Pandemics Observational Studies as Topic Brain Injuries Traumatic covid-19
Published by: BMJ Open
A systematic review and meta-analysis of the association between cyproterone acetate and intracranial meningiomas.
Keng Siang Lee, John JY Zhang, Ramez Kirollos, Thomas Santarius, Vincent Diong Weng Nga, Tseng Tsai Yeo
Mar 08, 2022
The influence of exposure to hormonal treatments, particularly cyproterone acetate (CPA), has been posited to contribute to the growth of meningiomas. Given the widespread use of CPA, this systematic review and meta-analysis...
Tensions between policy and practice
Autonomy Human Rights Involuntary treatment Mental health legislation Paternalism Adult Commitment of Mentally Ill Dangerous Behavior England Female Health Policy Humans Interview Psychological Length of Stay Male Mental Competency Mental Disorders Observational Studies as Topic Paternalism Patient Admission Patient Advocacy Patient Safety Risk Assessment Treatment Refusal
Electrocardiographic abnormalities in Chagas disease in the general population
Lyda Z Rojas, Marija Glisic, Laura Pletsch-Borba, Luis E Echeverría, Wichor M Bramer, Arjola Bano, Najada Stringa, Asija Zaciragic, Bledar Kraja, Eralda Asllanaj, Rajiv Chowdhury, Carlos A Morillo, Oscar L Rueda-Ochoa, Oscar H Franco, Taulant Muka
Sep 20, 2018
BACKGROUND: Chagas disease (CD) is a major public health concern in Latin America and a potentially serious emerging threat in non-endemic countries. Although the association between CD and cardiac abnormalities is widely...
The association between alcohol consumption and osteoarthritis
There is conflicting evidence for the association between alcohol consumption and common joint conditions such as Osteoarthritis (OA), which affects millions of people. We sought to determine the true association between alcohol...
Rapid Assay for Sick Children with Acute Lung infection Study (RASCALS)
John Alexander Clark, Iain Robert Louis Kean, Martin D Curran, Fahad Khokhar, Deborah White, Esther Daubney, Andrew Conway Morris, Vilas Navapurkar, Josefin Bartholdson Scott, Mailis Maes, Rachel Bousfield, Theodore Gouliouris, Shruti Agrawal, David Inwald, Zhenguang Zhang, M Estée Török, Stephen Baker, Nazima Pathan
Jan 10, 2022
INTRODUCTION: Lower respiratory tract infection (LRTI) is the most commonly treated infection in critically ill children. Pathogens are infrequently identified on routine respiratory culture, and this is a time-consuming...
PD-L1 protein expression in breast cancer is rare, enriched in basal-like tumours and associated with infiltrating lymphocytes.
HR Ali, S-E Glont, FM Blows, E Provenzano, S-J Dawson, B Liu, L Hiller, J Dunn, CJ Poole, S Bowden, HM Earl, PDP Pharoah, C Caldas
Jun 18, 2015
CD274 PD-L1 basal-like Breast Cancer immune checkpoint Lymphocytes B7-H1 Antigen Biomarkers Tumor Breast Neoplasms Carcinoma Basal Cell Female Follow-Up Studies Humans Immunoenzyme Techniques Lymphocytes Tumor-Infiltrating Neoplasm Staging Observational Studies as Topic Prognosis Randomized Controlled Trials as Topic Tissue Array Analysis
The risk of cardiovascular disease in women after miscarriage, stillbirth, and therapeutic abortion
Charlotte Muehlschlegel, Harry Kyriacou, Abdulrahman Al-Mohammad, Lowri A Foster-Davies, Fiona Simmons-Jones, Clare Oliver-Williams
Aug 04, 2020
Abortion cardiovascular disease coronary heart disease Meta-Analysis Miscarriage Protocol Stillbirth stroke Systematic review Abortion Induced Abortion Spontaneous Abortion Therapeutic Cardiovascular Diseases Female Humans Meta-Analysis as Topic Observational Studies as Topic Pregnancy Stillbirth Systematic Reviews as Topic
Propensity score analysis with partially observed covariates
Clémence Leyrat, Shaun R Seaman, Ian R White, Ian Douglas, Liam Smeeth, Joseph Kim, Matthieu Resche-Rigon, James R Carpenter, Elizabeth J Williamson
Jun 13, 2018
Missing covariates Rubin’s rules chained equations inverse probability of treatment weighting missingness pattern Bias Data Interpretation Statistical Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Models Statistical Observational Studies as Topic Pneumonia Probability Propensity Score Treatment Outcome
CASPA (CArdiac Sarcoidosis in PApworth) improving the diagnosis of cardiac involvement in patients with pulmonary sarcoidosis
Juan Carlos Quijano-Campos, Lynne Williams, Sharad Agarwal, Katharine Tweed, Robert Parker, Ajit Lalvani, Yi-da Chiu, Kane Dorey, Thomas Devine, Victoria Stoneman, Mark Toshner, Muhunthan Thillai
Nov 30, 2020
INTRODUCTION: Sarcoidosis is a multisystem disease, predominantly affecting the lungs but can involve the heart, resulting in cardiac sarcoidosis (CS). Patients require MRI/Positron Emission Tomography (PET) scans for diagnosis....
Evidence of a Causal Association Between Cancer and Alzheimer's Disease
Stroke in COVID-19
BACKGROUND: Coronavirus disease 2019 (COVID-19) has become a global pandemic, affecting millions of people. However, the relationship between COVID-19 and acute cerebrovascular diseases is unclear. AIMS: We aimed to characterize...
Cervical ripening at home or in-hospital-prospective cohort study and process evaluation (CHOICE) study
Sarah Jane Stock, Amarnath Bhide, Heather Richardson, Mairead Black, Cassandra Yuill, Mairi Harkness, Maggie Reid, Fiona Wee, Helen Cheyne, Christine McCourt, Dikshyanta Rana, Kathleen Anne Boyd, Julia Sanders, Neelam Heera, Jane Huddleston, Fiona Denison, Dharmintra Pasupathy, Neena Modi, Gordon Smith, John Norrie
Apr 21, 2021
Association between weight change and incidence of cardiovascular disease events and mortality among adults with type 2 diabetes
Jean Strelitz, Emma R Lawlor, Yue Wu, Annabel Estlin, Giri Nandakumar, Amy L Ahern, Simon J Griffin
Jan 31, 2022
Theory of general balance applied to step wedge designs.
Simon Bond
Nov 20, 2018
A standard idealized step-wedge design satisfies the requirements, in terms of the structure of the observation units, to be considered a balanced design and can be labeled as a criss-cross design (time crossed with cluster)...
Birthweight, Type 2 Diabetes Mellitus, and Cardiovascular Disease
Daniela Zanetti, Emmi Tikkanen, Stefan Gustafsson, James R Priest, Stephen Burgess, Erik Ingelsson
Aug 16, 2018
BACKGROUND: Low birthweight has been associated with a higher risk of hypertension, type 2 diabetes mellitus (T2D), and cardiovascular disease. The Barker hypothesis posits that intrauterine growth restriction resulting in lower...
cardiovascular disease Diabetes mellitus Type 2 Genetics Hypertension obesity Adult Aged Birth Weight Blood Glucose blood pressure Body Mass Index Cardiovascular Diseases Diabetes mellitus Type 2 Female Genome-Wide Association Study Humans Incidence Male Mendelian Randomization Analysis Middle Aged Observational Studies as Topic Risk Factors United States
Social determinants of depression and suicidal behaviour in the Caribbean
Catherine R Brown, Ian R Hambleton, Natasha Sobers-Grannum, Shawn M Hercules, Nigel Unwin, E Nigel Harris, Rainford Wilks, Marlene MacLeish, Louis Sullivan, Madhuvanti M Murphy, U.S. Caribbean Alliance for Health Disparities Research Group (USCAHDR)
Jul 18, 2019
BACKGROUND: Depressive disorder is the largest contributor to years lived with disability in the Caribbean, adding 948 per 100,000 in 2013. Depression is also a major risk factor for suicidal behaviour. Social inequalities...
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