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Screening for Barrett's Oesophagus
PURPOSE OF REVIEW: The targeted approach adopted for Barrett's oesophagus (BO) screening is sub-optimal considering the large proportion of BO cases that are currently missed. We reviewed the literature highlighting recent...
Low-cost and clinically applicable copy number profiling using repeat DNA.
Sam Abujudeh, Sebastian S Zeki, Meta CJ van Lanschot, Mark Pusung, Jamie MJ Weaver, Xiaodun Li, Ayesha Noorani, Andrew J Metz, Jan Bornschein, Lawrence Bower, Ahmad Miremadi, Rebecca C Fitzgerald, Edward R Morrissey, Andy G Lynch
Sep 17, 2022
BACKGROUND: Somatic copy number alterations (SCNAs) are an important class of genomic alteration in cancer. They are frequently observed in cancer samples, with studies showing that, on average, SCNAs affect 34% of a cancer...
Low-cost and clinically applicable copy number profiling using repeat DNA
Abstract
Background
Somatic copy number alterations (SCNAs) are an important class of genomic alteration in cancer. They are...
Sam Abujudeh, Sebastian S Zeki, Meta CJ van Lanschot, Mark Pusung, Jamie MJ Weaver, Xiaodun Li, Ayesha Noorani, Andrew J Metz, Jan Bornschein, Lawrence Bower, Ahmad Miremadi, Rebecca C Fitzgerald, Edward R Morrissey, Andy G Lynch
Aug 17, 2022
Aneuploidy in targeted endoscopic biopsies outperforms other tissue biomarkers in the prediction of histologic progression of Barrett's oesophagus
Andreas V Hadjinicolaou, Sanne N van Munster, Achilleas Achilleos, Jose Santiago Garcia, Sarah Killcoyne, Krish Ragunath, Jacques JGHM Bergman, Rebecca C Fitzgerald, Massimiliano di Pietro
Apr 16, 2020
BARRETT'S OESOPHAGUS Biomarkers dysplasia Histologic progression Oesophageal adenocarcinoma Adenocarcinoma Aged Aged 80 and over Aneuploidy Barrett Esophagus Core Binding Factor Alpha 3 Subunit Cyclin A Cyclin-Dependent Kinase Inhibitor p16 Disease Progression endoscopy Esophageal Neoplasms Female Genetic Markers Humans Logistic Models Male Membrane Proteins Middle Aged Neoplasm Proteins Prospective Studies Tumor Suppressor Protein p53
Alterations in the Ca2+ toolkit in oesophageal adenocarcinoma.
Alana L Cutliffe, Sharon L McKenna, Darshan S Chandrashekar, Alvin Ng, Ginny Devonshire, Rebecca C Fitzgerald, Tracey R O'Donovan, John J Mackrill
Oct 01, 2022
AIM: To investigate alterations in transcription of genes, encoding Ca2+ toolkit proteins, in oesophageal adenocarcinoma (OAC) and to assess associations between gene expression, tumor grade, nodal-metastatic stage, and patient...