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MTL-CEBPA, a Small Activating RNA Therapeutic Upregulating C/EBP-α, in Patients with Advanced Liver Cancer
Debashis Sarker, Ruth Plummer, Tim Meyer, Mikael H Sodergren, Bristi Basu, Cheng Ean Chee, Kai-Wen Huang, Daniel H Palmer, Yuk Ting Ma, TR Jeff Evans, Duncan RC Spalding, Madhava Pai, Rohini Sharma, David J Pinato, James Spicer, Sarah Hunter, Vineet Kwatra, Joanna P Nicholls, David Collin, Robert Nutbrown, Helen Glenny, Sonia Fairbairn, Vikash Reebye, Jon Voutila, Stephanie Dorman, Pinelopi Andrikakou, Peter Lloyd, Steve Felstead, Jenni Vasara, Robert Habib, Chris Wood, Pal Saetrom, Hans E Huber, David C Blakey, John J Rossi, Nagy Habib
May 13, 2020
PURPOSE: Transcription factor C/EBP-α (CCAAT/enhancer-binding protein alpha) acts as a master regulator of hepatic and myeloid functions and multiple oncogenic processes. MTL-CEBPA is a first-in-class small activating RNA...
Adult Aged Aged 80 and over Antineoplastic Agents CCAAT-Enhancer-Binding Proteins Carcinoma Hepatocellular Dose-Response Relationship Drug Female Gene Expression Regulation Neoplastic Humans Infusions Intravenous Liposomes Liver Neoplasms Male Middle Aged Nanoparticles Neoplasm Staging Oligoribonucleotides Treatment Outcome Tumor Microenvironment Up-Regulation