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Mtrr hypomorphic mutation alters liver morphology, metabolism and fuel storage in mice.
5-methyl-THF 5-methyltetrahydofolate Agl amylo-alpha-1 6-glucosidase 4-alpha-glucanotransferase gene BCA bicinchoninic acid Bhmt betaine-homocysteine S-methyltransferase gene Ce cholesteryl-ester Cebpa CCAAT/enhancer binding protein (C/EBP) alpha gene Cer ceramide DAG diacylglycerol Ddit3 DNA damage inducible transcript 3 gene ETS electron transport system FCCP p-trifluoromethoxyphenyl hydrazine FFA free fatty acid G6pc glucose 6-phophastase gene Gbe1 glycogen branching enzyme 1 gene Glycogen GSK3 glycogen synthase kinase gene Gyg glycogenin gene Gys2 glycogen synthase 2 gene HOAD 3-hydoxyacyl-CoA dehydrogenase Hepatic fuel storage Isca1 iron‑sulfur cluster assembly 1 gene JO2 oxygen flux LC-MS liquid chromatography-mass spectrometry LPC lysophosphatidylcholine lipidomics Liver metabolism Mitochondrial function MTHFR methylenetetrahydrofolate reductase gene Mtr methionine synthase gene (also MS) MTRR methionine synthase reductase gene (also MSR) Myc myelocytomatosis oncogene NAFLD non-alcoholic fatty liver disease NASH non-alcoholic steatohepatitis Ndufs NADH:ubiquinone oxidoreductase core subunit (ETS complex I) gene OXPHOS oxidative phosphorylation One‑carbon metabolism PA phosphatidic acid PAS periodic acid Schiff PC phosphatidylcholine PE phosphatidylethanolamine PG phosphatidylglycerol PI phosphatidylinositol PIP phosphatidylinositol phosphate(s) PL phospholipid PS phosphatidylserine RIPA Radioimmunoprecipitation assay SAH S-adenosylhomocysteine SAM S-adenosylmethionine SM sphingomyelin TAG triacylglycerol Ugp2 UDP-glucose pyrophophorylase 2 gene gt gene-trap
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