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Results: 21
Catalytic Transfer Hydrogenation of Nitroalkenes to Primary Amines
Brendan Phillips
Jan 01, 0001
This work describes synthetic methodology development in organic chemistry. The goal of this work is to demonstrate new ways of making biologically-relevant molecules that are in line with the principles of green chemistry...
nitroalkenes transfer hydrogenation catalytic Green chemistry Amines medicinal chemistry asymmetric synthesis Chemistry Environmental Chemistry Medicinal-Pharmaceutical Chemistry Organic chemistry Physical Sciences and Mathematics
Published by: Ursinus College
Analysis of Fluorogenic Probes for the Detection of Chlorite in Drinking Water
Morgan McFarland
Jan 01, 0001
Chlorite is a common water contaminant that results from the chlorination and purification of drinking water. The overconsumption of chlorite is associated with numerous birth defects and abnormal changes in red blood cells and...
Published by: Ursinus College
Computational and Literature Analysis of Photoinduced Electron Transfer in Fluorophores Containing Nitrogen Donors
Paige D'Elia
Jan 01, 0001
The rational design of chemical tools that only fluoresce when they react with a desired analyte is useful for biological imaging, detection, as well as for creation of other luminescent materials. These chemical tools are...
Published by: Ursinus College
Toward the Rational Design of Photo-induced Electron Transfer (PET)-Based Fluorescent Probes
Julia Dorsheimer
Jan 01, 0001
Small molecule fluorescent probes are commonly used in imaging applications and sensors including detecting environmental analytes or elucidating biological phenomena. Many of these compounds function via a change in brightness...
Fluorescence quenching probes photoinduced electron transfer Chemistry Organic chemistry Physical Sciences and Mathematics
Published by: Ursinus College
Synthesis, Suzuki Couplings, and Small-molecule Inhibitors
Patrick Gray
Jan 01, 0001
The goal of this research project was to design and synthesize small-molecule inhibitors using reductive amination, Suzuki coupling, and the addition of protecting groups.
small molecules INHIBITORS reductive amination Suzuki coupling Organic chemistry Physical Sciences and Mathematics
Published by: Ursinus College
Preliminary studies
Muhammad Iqbal, Tai-Ping Fan, David Watson, Samya Alenezi, Khaled Saleh, Muhamad Sahlan
Sep 10, 2019
Several studies have previously reported propolis, or its constituents, to inhibit tumour angiogenesis. The anti-angiogenic activity of two Indonesian stingless bee propolis extracts from Sulawesi Island on vascular cells were...
Toward the Development of a Carbon Nanotube Drug Delivery System for Clarithromycin
Broderick Johnson
Jan 01, 0001
Carbon nanotubes have recently gained interest as potential vehicles for use in advanced drug delivery systems. A highly relevant application for such systems is the treatment of antibiotic resistant strains of bacteria....
Carbon nanotubes Antibiotics Drug delivery clarithromycin Antibiotic Resistant Bacteria Amino Acids, Peptides, and Proteins Bacteria Bacterial Infections and Mycoses Biochemistry Chemistry Materials chemistry Medicinal Chemistry and Pharmaceutics Molecular Biology nanomedicine Organic chemistry physical chemistry Physical Sciences and Mathematics
Published by: Ursinus College
Towards the Rational Design of Photoinduced Electron Transfer (PET)-Based Fluorescent Probes
Matthew Balestriere
Jan 01, 0001
Fluorescent probes are used in chemical, biological, and environmental studies as a means of detecting the presence of a desired target molecule. These probes, when reacted with their target molecule, "turn on" and emit light...
Fluorescent probe Fluorophore PeT-quenching Photo-induced Electron Transfer Chemistry Organic chemistry Physical Sciences and Mathematics
Published by: Ursinus College
Direct Amination of Hydroxyfluorophores via One-Pot Smiles Rearrangement Hydrolysis
Paige D'Elia
Jan 01, 0001
Fluorophores, such as fluorescein, are economical and can be applied to many fields such as biochemical research, to label and track cells or to diagnose infections, environmental sciences, to track water movements in...
Published by: Ursinus College
Design and Synthesis of Small-molecule Inhibitors Using Reductive Amination, Hydrogenolysis, Vilsmeier-Haack Formylation, and Nucleophilic Substitution
Ethan Belville
Jan 01, 0001
The goal of this project was to design and synthesize small-molecule inhibitors using reductive amination, hydrogenolysis, Vilsmeier-Haack formylation, and nucleophilic substitution reactions.
Published by: Ursinus College
Max Bergmann, 1935
The Rockefeller University
Jan 01, 0001
Dr. Max Bergmann. Proteins and Proteolytic Enzymes
Lecture delivered October 17th, 1935
Published with permission from the Harvey Society
Published by: The Williams & Wilkins Company
Synthesis and Photophysical Characterization of Novel Rhodols
Cael Milbourne
Jan 01, 0001
Fluorescence imaging is a tool often used in biology and for the detection of analytes of interest. However, many chemical tools used have limitations, such as difficult functionalization, poor solubility, and undesirable...
Published by: Ursinus College
Improved Substrate Scope and Linker Optimization for Coumarin-Based Smiles Rearrangement
Evan Yanagawa
Jan 01, 0001
Fluorophores are light-emitting compounds that are utilized mainly in fields such as environmental testing, biological imaging and even forensics. Fluorophore molecules are consisted of the fluorescent portion, a chromophore...
Published by: Ursinus College
Synthesis of Fluorescent Rhodols from Fluorescein Derivatives via Smiles Rearrangement
Julia Shoemaker
Jan 01, 0001
The xanthene family of fluorophores, such as fluorescein and rhodamines, is commonly used as a scaffold in many different chemical tools because of the tunability of their photophysical properties and reactivity. Hybrid...
Published by: Ursinus College
Layman Craig, 1949
The Rockefeller University
Jan 01, 0001
Lyman C. Craig. Isolation and characterization of biologically important substances
Lecture delivered December 15, 1949
Posted with permission
Published by: Charles C. Thomas Publisher
Development of a Reaction Based Chemical Sensor for the Detection of Atrazine
Gunther S Druker
Jan 01, 0001
Ground water concentration of atrazine has increased due to run-off from farms employing this common herbicide. This is of concern because atrazine has been shown to function as an endocrine disruptor. Fluorophores are commonly...
Published by: Ursinus College
Facile Conversion of Hydroxyfluorophores to Aminofluorophores via Smiles Rearrangement
Omar Elghawy
Jan 01, 0001
Small-molecule fluorophores are compounds that absorb and re-emit light that see many applications in areas including biological imaging, environmental testing, and laser dyes. Yet despite the wide range of fluorophores...
Published by: Ursinus College
Synthesis and Analysis of Small Fluorogenic Probes for Chlorite Detection
Dylan Ford
Jan 01, 0001
Chlorite is a common water contaminant that is most commonly introduced to drinking water sources through wastewater disinfection and textile bleaching. Consumption of elevated levels of chlorite have been shown to produce...
fluorogenic probe fluoresence activity-based sensing activity sensing detection Chlorite Chemistry Environmental Chemistry Organic chemistry Physical Sciences and Mathematics
Published by: Ursinus College
Synthesis and Analysis of Reaction Based Fluorogenic Probes for the Detection of Chlorite in Drinking Water
William Krueger
Jan 01, 0001
Chlorite is a common drinking water contaminant resulting most often from the decontamination process at water treatment plants. Excess levels of chlorite have been linked to several health issues, including sickle cell, birth...
Organic chemistry Fluorescent probes Synthesis Chlorite analytical chemistry Chemistry Organic chemistry
Published by: Ursinus College
Digging Deeper: The Impact of Depth on Soil Organic Matter Stabilization Dynamics in a Forage System
Finnleigh Shane Doherty
Jan 01, 0001
Utilizing agriculture as a resource to mitigate the increased atmospheric CO2 fueling the climate crisis requires transformation of soils from a carbon (C) source into a C sink by investing in root-microbial communities to...
Forage Crops depth soil organic matter POX-C Mineralizable C ATR- FTIR Spectroscopy analytical chemistry biogeochemistry Organic chemistry Soil Science
Published by: Ursinus College
Synthesis and Analysis of 7-Nitroso-4-Methylcoumarin as a Reactivity-Based Probe
Morgyn Henry
Jan 01, 0001
Reactivity-based probes are commonly used in various imaging types to detect analytes or biomolecules such as proteins of interest. By tagging the molecule of interest, the probe will elicit either a fluorogenic or colorimetric...
Published by: Ursinus College