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Results: 10
Dissociable dopaminergic and pavlovian influences in goal-trackers and sign-trackers on a model of compulsive checking in OCD
D. M. Eagle, C. Schepisi, S. Chugh, S. Desai, S. Y. S. Han, T. Huang, J. J. Lee, C. Sobala, W. Ye, A. L. Milton, T. W. Robbins
Sep 08, 2021
Abstract: Rationale: Checking is a functional behaviour that provides information to guide behaviour. However, in obsessive-compulsive disorder (OCD), checking may escalate to dysfunctional levels. The processes underpinning the...
Dopamine D2-like receptor stimulation blocks negative feedback in visual and spatial reversal learning in the rat
Johan Alsiö, Benjamin U. Phillips, Júlia Sala-Bayo, Simon R. O. Nilsson, Teresa C. Calafat-Pla, Arazo Rizwand, Jessica M. Plumbridge, Laura López-Cruz, Jeffrey W. Dalley, Rudolf N. Cardinal, Adam C. Mar, Trevor W. Robbins
Jun 18, 2020
Abstract: Rationale: Dopamine D2-like receptors (D2R) are important drug targets in schizophrenia and Parkinson’s disease, but D2R ligands also cause cognitive inflexibility such as poor reversal learning. The specific role of...
Dissociable dopaminergic and pavlovian influences in goal-trackers and sign-trackers on a model of compulsive checking in OCD
D. M. Eagle, C. Schepisi, S. Chugh, S. Desai, S. Y. S. Han, T. Huang, J. J. Lee, C. Sobala, W. Ye, A. L. Milton, T. W. Robbins
Nov 23, 2020
Abstract: Rationale: Checking is a functional behaviour that provides information to guide behaviour. However, in obsessive-compulsive disorder (OCD), checking may escalate to dysfunctional levels. The processes underpinning the...
Changes in behaviors after diagnosis of type 2 diabetes and 10-year incidence of cardiovascular disease and mortality
Jean Strelitz, Amy L. Ahern, Gráinne H. Long, Clare E. Boothby, Nicholas J. Wareham, Simon J. Griffin
Jul 31, 2020
Abstract: Background: Large changes in health behaviors achieved through intensive lifestyle intervention programs improve cardiovascular disease (CVD) risk factors among adults with type 2 diabetes. However, such interventions...
Follow‐up MRI appearance of the surgical site in dogs treated for thoracolumbar intervertebral disc herniation and showing ongoing or recurrent neurological symptoms
Abstract: Reherniation and reoperation rates of 4.5%–36% are reported in canine patients treated for intervertebral disc herniation (IVDH). Decision‐making for surgical reintervention can prove challenging, especially since...
Decoding a highly mixed Kazakh genome
Madina Seidualy, Asta Blazyte, Sungwon Jeon, Youngjune Bhak, Yeonsu Jeon, Jungeun Kim, Anders Eriksson, Dan Bolser, Changhan Yoon, Andrea Manica, Semin Lee, Jong Bhak
Jun 06, 2020
Abstract: We provide a Kazakh whole genome sequence (MJS) and analyses with the largest comparative Kazakh genomic data available to date. We found 102,240 novel SNVs and a high level of heterozygosity. ADMIXTURE analysis...
Computational modelling reveals contrasting effects on reinforcement learning and cognitive flexibility in stimulant use disorder and obsessive-compulsive disorder
Jonathan W. Kanen, Karen D. Ersche, Naomi A. Fineberg, Trevor W. Robbins, Rudolf N. Cardinal
Jul 19, 2020
Abstract: Rationale: Disorders of compulsivity such as stimulant use disorder (SUD) and obsessive-compulsive disorder (OCD) are characterised by deficits in behavioural flexibility, some of which have been captured using...
Impairments in reinforcement learning do not explain enhanced habit formation in cocaine use disorder
T. V. Lim, R. N. Cardinal, G. Savulich, P. S. Jones, A. A. Moustafa, T. W. Robbins, K. D. Ersche
Jul 31, 2020
Abstract: Rationale: Drug addiction has been suggested to develop through drug-induced changes in learning and memory processes. Whilst the initiation of drug use is typically goal-directed and hedonically motivated, over time...
Trust in genomic data sharing among members of the general public in the UK, USA, Canada and Australia
Richard Milne, Katherine I. Morley, Heidi Howard, Emilia Niemiec, Dianne Nicol, Christine Critchley, Barbara Prainsack, Danya Vears, James Smith, Claire Steed, Paul Bevan, Jerome Atutornu, Lauren Farley, Peter Goodhand, Adrian Thorogood, Erika Kleiderman, Anna Middleton
Sep 16, 2020
Abstract: Trust may be important in shaping public attitudes to genetics and intentions to participate in genomics research and big data initiatives. As such, we examined trust in data sharing among the general public. A...
Dopaminergic drug treatment remediates exaggerated cingulate prediction error responses in obsessive-compulsive disorder
Graham K. Murray, Franziska Knolle, Karen D. Ersche, Kevin J. Craig, Sanja Abbott, Shaila S. Shabbir, Naomi A. Fineberg, John Suckling, Barbara J. Sahakian, Edward T. Bullmore, Trevor W. Robbins
Jun 15, 2020
Abstract: Rationale: Patients with obsessive-compulsive disorder (OCD) have been found to show exaggerated error responses and prediction error learning signals in a variety of EEG and fMRI tasks, with data converging on the...