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Structure-based design of allosteric calpain-1 inhibitors populating a novel bioactivity space.
Leen Kalash, Joel Cresser-Brown, Johnny Habchi, Connor Morgan, David J Miller, Robert C Glen, Rudolf K Allemann, Andreas Bender
Nov 13, 2018
Dimeric calpains constitute a promising therapeutic target for many diseases such as cardiovascular, neurodegenerative and ischaemic disease. The discovery of selective calpain inhibitors, however, has been extremely...