Search
Results: 4
piRNA-guided co-transcriptional silencing coopts nuclear export factors.
Martin H Fabry, Filippo Ciabrelli, Marzia Munafò, Evelyn L Eastwood, Emma Kneuss, Ilaria Falciatori, Federica A Falconio, Gregory J Hannon, Benjamin Czech
Jun 21, 2019
The PIWI-interacting RNA (piRNA) pathway is a small RNA-based immune system that controls the expression of transposons and maintains genome integrity in animal gonads. In Drosophila, piRNA-guided silencing is achieved, in part...
D. melanogaster PIWI proteins Chromosomes Gene Expression nuclear export factor piRNA pathway transcriptional gene silencing transposon control Active Transport Cell Nucleus Animals Chromatin Drosophila melanogaster Gene Silencing Nuclear Proteins Protein Binding Protein Stability RNA Small Interfering Transcription Genetic
Specialization of the Drosophila nuclear export family protein Nxf3 for piRNA precursor export.
Emma Kneuss, Marzia Munafò, Evelyn L Eastwood, Undine-Sophie Deumer, Jonathan B Preall, Gregory J Hannon, Benjamin Czech
Aug 13, 2019
The PIWI-interacting RNA (piRNA) pathway is a conserved small RNA-based immune system that protects animal germ cell genomes from the harmful effects of transposon mobilization. In Drosophila ovaries, most piRNAs originate from...
PIWI proteins RNA export nuclear export factor piRNA clusters transposon control Active Transport Cell Nucleus Animals DNA Transposable Elements Drosophila Drosophila Proteins Intracellular Signaling Peptides and Proteins Nucleocytoplasmic Transport Proteins RNA Precursors RNA Small Interfering RNA-Binding Proteins
One Loop to Rule Them All
The PIWI-interacting RNA (piRNA) pathway is a conserved defense mechanism that protects the genetic information of animal germ cells from the deleterious effects of molecular parasites, such as transposons. Discovered nearly a...
PIWI proteins piRNA biogenesis ping-pong amplification loop post-transcriptional gene silencing (PTGS) transcriptional gene silencing (TGS) transposon control Animals Argonaute Proteins Chromosomal Proteins Non-Histone Drosophila Proteins Drosophila melanogaster Gene Silencing Histones Humans Microtubule-Associated Proteins RNA Messenger RNA Small Interfering RNA-Binding Proteins Transcription Genetic
Daedalus and Gasz recruit Armitage to mitochondria, bringing piRNA precursors to the biogenesis machinery
Marzia Munafò, Vera Manelli, Federica A Falconio, Ashley Sawle, Emma Kneuss, Evelyn L Eastwood, Jun Wen Eugene Seah, Benjamin Czech, Gregory J Hannon
May 29, 2019
The Piwi-interacting RNA (piRNA) pathway is a small RNA-based immune system that silences mobile genetic elements in animal germlines. piRNA biogenesis requires a specialized machinery that converts long singlestranded...