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Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp620 Risk Allele Drive the Expansion of FOXP3+ Regulatory T Cells and PD-1 Expression.
Ricardo C Ferreira, Xaquin Castro Dopico, João J Oliveira, Daniel B Rainbow, Jennie H Yang, Dominik Trzupek, Sarah A Todd, Mhairi McNeill, Maristella Steri, Valeria Orrù, Edoardo Fiorillo, Daniel JM Crouch, Marcin L Pekalski, Francesco Cucca, Tim I Tree, Tim J Vyse, Linda S Wicker, John A Todd
Jan 03, 2020
In systemic lupus erythematosus (SLE), perturbed immunoregulation underpins a pathogenic imbalance between regulatory and effector CD4+ T-cell activity. However, to date, the characterization of the CD4+ regulatory T cell (Treg)...
FOXP3 PD-1 PTPN22 Arg620Trp Autoimmunity Immunotherapy regulatory T cells (tregs) systemic lupus erythematosus (SLE) type I interferon Adult Aged Aged 80 and over Alleles Autoimmunity Female Forkhead Transcription Factors Humans Interleukin-2 Lupus Erythematosus Systemic Male Middle Aged Programmed Cell Death 1 Receptor Protein Tyrosine Phosphatase Non-Receptor Type 22 risk T-Lymphocytes Regulatory Young Adult