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Complexome profile of Toxoplasma gondii mitochondria identifies divergent subunits of respiratory chain complexes including new subunits of cytochrome bc1 complex.
Andrew E Maclean, Hannah R Bridges, Mariana F Silva, ShuJing Ding, Jana Ovciarikova, Judy Hirst, Lilach Sheiner
Mar 23, 2021
The mitochondrial electron transport chain (mETC) and F1Fo-ATP synthase are of central importance for energy and metabolism in eukaryotic cells. The Apicomplexa, important pathogens of humans causing diseases such as...
DNA replication dynamics during erythrocytic schizogony in the malaria parasites Plasmodium falciparum and Plasmodium knowlesi.
Malaria parasites are unusual, early-diverging protozoans with non-canonical cell cycles. They do not undergo binary fission, but divide primarily by schizogony. This involves the asynchronous production of multiple nuclei...
Genome-wide subcellular protein map for the flagellate parasite Trypanosoma brucei.
Growth rate, transmission mode and virulence in human pathogens.
The harm that pathogens cause to hosts during infection, termed virulence, varies across species from negligible to a high likelihood of rapid death. Classic theory for the evolution of virulence is based on a trade-off between...
Quantification of parasite clearance in Plasmodium knowlesi infections.
Jeyamalar T Thurai Rathnam, Matthew J Grigg, Saber Dini, Timothy William, Sitti Saimah Sakam, Daniel J Cooper, Giri S Rajahram, Bridget E Barber, Nicholas M Anstey, Ali Haghiri, Megha Rajasekhar, Julie A Simpson
Feb 16, 2023
The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite.
Min Zhang, Chengqi Wang, Jenna Oberstaller, Phaedra Thomas, Thomas D Otto, Debora Casandra, Sandhya Boyapalle, Swamy R Adapa, Shulin Xu, Katrina Button-Simons, Matthew Mayho, Julian C Rayner, Michael T Ferdig, Rays HY Jiang, John H Adams
Oct 04, 2021
The emergence and spread of Plasmodium falciparum parasites resistant to front-line antimalarial artemisinin-combination therapies (ACT) threatens to erase the considerable gains against the disease of the last decade. Here, we...
Genome-wide localization of histone variants in Toxoplasma gondii implicates variant exchange in stage-specific gene expression.
Sheila C Nardelli, Natalie C Silmon de Monerri, Laura Vanagas, Xiaonan Wang, Zoi Tampaki, William J Sullivan, Sergio O Angel, Kami Kim
Mar 18, 2022
BACKGROUND: Toxoplasma gondii is a protozoan parasite that differentiates from acute tachyzoite stages to latent bradyzoite forms in response to environmental cues that modify the epigenome. We studied the distribution of the...
The in vivo RNA structurome of the malaria parasite Plasmodium falciparum, a protozoan with an A/U-rich transcriptome.
Plasmodium falciparum, a protozoan parasite and causative agent of human malaria, has one of the most A/T-biased genomes sequenced to date. This may give the genome and the transcriptome unusual structural features. Recent...
Hosts elevate either within-clutch consistency or between-clutch distinctiveness of egg phenotypes in defence against brood parasites.
Eleanor M Caves, Tanmay Dixit, John FR Colebrook-Robjent, Lazaro Hamusikili, Martin Stevens, Rose Thorogood, Claire N Spottiswoode
May 18, 2021
The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite.
Min Zhang, Chengqi Wang, Jenna Oberstaller, Phaedra Thomas, Thomas D Otto, Debora Casandra, Sandhya Boyapalle, Swamy R Adapa, Shulin Xu, Katrina Button-Simons, Matthew Mayho, Julian C Rayner, Michael T Ferdig, Rays H Y Jiang, John H Adams
Aug 28, 2021
The emergence and spread of Plasmodium falciparum parasites resistant to front-line antimalarial artemisinin-combination therapies (ACT) threatens to erase the considerable gains against the disease of the last decade. Here, we...
Animals Parasites Plasmodium falciparum Malaria Falciparum Fever Terpenes Artemisinins Temperature Signal Transduction Transcription Genetic Gene Expression Regulation Heat-Shock Response Drug Resistance Phenotype Mutation Unfolded Protein Response Apicoplasts
Published by: Nature Communications
Parasite co-infection
Laboratory studies of pathogens aim to limit complexity in order to disentangle the important parameters contributing to an infection. However, pathogens rarely exist in isolation, and hosts may sustain co-infections with...
Factors at multiple scales drive parasite community structure.
Visual complexity of egg patterns predicts egg rejection according to Weber's law.
Tanmay Dixit, Andrei L Apostol, Kuan-Chi Chen, Anthony JC Fulford, Christopher P Town, Claire N Spottiswoode
Dec 22, 2022
Rapid diagnosis of parasitic diseases
BACKGROUND: Parasitic diseases are one of the world's most devastating and prevalent infections, causing millions of morbidities and mortalities annually. In the past, many of these infections have been linked predominantly to...
Genomic analysis finds no evidence of canonical eukaryotic DNA processing complexes in a free-living protist.
Dayana E Salas-Leiva, Eelco C Tromer, Bruce A Curtis, Jon Jerlström-Hultqvist, Martin Kolisko, Zhenzhen Yi, Joan S Salas-Leiva, Lucie Gallot-Lavallée, Shelby K Williams, Geert JPL Kops, John M Archibald, Alastair GB Simpson, Andrew J Roger
Jan 05, 2022
Embryo movement is more frequent in avian brood parasites than birds with parental reproductive strategies.
Stephanie C McClelland, Miranda Reynolds, Molly Cordall, Mark E Hauber, Wolfgang Goymann, Luke A McClean, Silky Hamama, Jess Lund, Tanmay Dixit, Matthew IM Louder, Ignas Safari, Marcel Honza, Claire N Spottiswoode, Steven J Portugal
Jan 06, 2022
Protein kinase A negatively regulates Ca2+ signalling in Toxoplasma gondii.
Alessandro D Uboldi, Mary-Louise Wilde, Emi A McRae, Rebecca J Stewart, Laura F Dagley, Luning Yang, Nicholas J Katris, Sanduni V Hapuarachchi, Michael J Coffey, Adele M Lehane, Cyrille Y Botte, Ross F Waller, Andrew I Webb, Malcolm J McConville, Christopher J Tonkin
Dec 13, 2018
The phylum Apicomplexa comprises a group of obligate intracellular parasites that alternate between intracellular replicating stages and actively motile extracellular forms that move through tissue. Parasite cytosolic Ca2+...
Parasitic infections and resource economy of Danish Iron Age settlement through ancient DNA sequencing.
Katrine Wegener Tams, Martin Jensen Søe, Inga Merkyte, Frederik Valeur Seersholm, Peter Steen Henriksen, Susanne Klingenberg, Eske Willerslev, Kurt H Kjær, Anders Johannes Hansen, Christian Moliin Outzen Kapel
Sep 11, 2018
In this study, we screen archaeological soil samples by microscopy and analyse the samples by next generation sequencing to obtain results with parasites at species level and untargeted findings of plant and animal DNA. Three...
'Fight the parasite'
Francesca Porcu, Cinzia Cantacessi, Giorgia Dessì, Maria Francesca Sini, Fahad Ahmed, Lia Cavallo, Francesca Nonnis, Katherine Gibson, Cecilia Varcasia, Gaelle Joanny, Antonio Scala, Claudia Tamponi, Antonio Varcasia
Dec 08, 2022
BACKGROUND: Cystic echinococcosis (CE) is a widespread zoonosis and a significant economic concern and cause of morbidity in humans. A scarcity of education on the sources of CE infection and containment measures is considered...
Host and gut microbiome modulate the antiparasitic activity of nectar metabolites in a bumblebee pollinator.
Hauke Koch, Vita Welcome, Amy Kendal-Smith, Lucy Thursfield, Iain W Farrell, Moses K Langat, Mark JF Brown, Philip C Stevenson
Jun 07, 2022
Characterising genome architectures using genome decomposition analysis.
Genome architecture describes how genes and other features are arranged in genomes. These arrangements reflect the evolutionary pressures on genomes and underlie biological processes such as chromosomal segregation and the...
Visual complexity of egg patterns predicts egg rejection according to Weber's law.
Tanmay Dixit, Andrei L Apostol, Kuan-Chi Chen, Anthony JC Fulford, Christopher P Town, Claire N Spottiswoode
Aug 20, 2022
Visual complexity is ubiquitous in nature. Drivers of complexity include selection in coevolutionary arms races between antagonists. However, the causes and consequences of biological complexity and its perception are largely...
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