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The Relationship Between Blood Sample Volume and Diagnostic Sensitivity of Blood Culture for Typhoid and Paratyphoid Fever
BACKGROUND: Blood culture is the standard diagnostic method for typhoid and paratyphoid (enteric) fever in surveillance studies and clinical trials, but sensitivity is widely acknowledged to be suboptimal. We conducted a...
Evaluation of the Clinical and Microbiological Response to Salmonella Paratyphi A Infection in the First Paratyphoid Human Challenge Model.
Hazel C Dobinson, Malick M Gibani, Claire Jones, Helena B Thomaides-Brears, Merryn Voysey, Thomas C Darton, Claire S Waddington, Danielle Campbell, Iain Milligan, Liqing Zhou, Sonu Shrestha, Simon A Kerridge, Anna Peters, Zoe Stevens, Audino Podda, Laura B Martin, Flavia D'Alessio, Duy Pham Thanh, Buddha Basnyat, Stephen Baker, Brian Angus, Myron M Levine, Christoph J Blohmke, Andrew J Pollard
Apr 10, 2019
BACKGROUND: To expedite the evaluation of vaccines against paratyphoid fever, we aimed to develop the first human challenge model of Salmonella enterica serovar Paratyphi A infection. METHODS: Two groups of 20 participants...
Genome-wide analysis provides a deeper understanding of the population structure of the Salmonella enterica serotype Paratyphi B complex in Bangladesh.
Sadia Isfat Ara Rahman, Alyce Taylor-Brown, Farhana Khanam, Ashraful Islam Khan, Gal Horesh, Zoe A Dyson, Yasmin Ara Begum, Emran Kabir Chowdhury, Firdausi Qadri, Gordon Dougan, Nicholas R Thomson
Oct 11, 2021
The Salmonella enterica serotype Paratyphi B complex causes a wide range of diseases, from gastroenteritis to paratyphoid fever, depending on the biotypes Java and sensu stricto. The burden of Paratyphi B biotypes in Bangladesh...
Salmonella Paratyphi B enteric disease Serotyping SURVEILLANCE whole-genome sequencing Adolescent Adult Aged Aged 80 and over Bangladesh Child Child Preschool Female Humans Infant Infant Newborn Male Middle Aged Paratyphoid Fever salmonella Salmonella Infections Serogroup Serotyping United Kingdom whole genome sequencing Young Adult
Evaluating PCR-Based Detection of Salmonella Typhi and Paratyphi A in the Environment as an Enteric Fever Surveillance Tool.
Senjuti Saha, Arif M Tanmoy, Jason R Andrews, Mohammad SI Sajib, Alexander T Yu, Stephen Baker, Stephen P Luby, Samir K Saha
Aug 04, 2021
With prequalification of a typhoid conjugate vaccine by the World Health Organization, countries are deciding whether and at what geographic scale to provide the vaccine. Optimal local data to clarify typhoid risk are expensive...
Very long O-antigen chains of Salmonella Paratyphi A inhibit inflammasome activation and pyroptotic cell death.
Elli Mylona, Julia Sanchez-Garrido, Trang Nguyen Hoang Thu, Sabina Dongol, Abhilasha Karkey, Stephen Baker, Avinash R Shenoy, Gad Frankel
Jan 22, 2021
Salmonella Paratyphi A (SPtA) remains one of the leading causes of enteric (typhoid) fever. Yet, despite the recent increased rate of isolation from patients in Asia, our understanding of its pathogenesis is incomplete. Here we...
FepE O-antigen Salmonella paratyphi A Salmonella typhimurium caspase-4 enteric fever Inflammasomes pyroptosis Bacterial Proteins Caspases HeLa Cells Humans Inflammasomes Intracellular Signaling Peptides and Proteins MACROPHAGES O Antigens Paratyphoid Fever Phosphate-Binding Proteins pyroptosis Salmonella paratyphi A THP-1 Cells Type III Secretion Systems Virulence Virulence Factors
Treatment Response in Enteric Fever in an Era of Increasing Antimicrobial Resistance
Corinne N Thompson, Abhilasha Karkey, Sabina Dongol, Amit Arjyal, Marcel Wolbers, Thomas Darton, Jeremy J Farrar, Guy E Thwaites, Christiane Dolecek, Buddha Basnyat, Stephen Baker
Apr 10, 2019
BACKGROUND.: Enteric fever, caused by Salmonella Typhi and Salmonella Paratyphi A, is the leading cause of bacterial febrile disease in South Asia. METHODS.: Individual data from 2092 patients with enteric fever randomized into...
Nepal Antimicrobial resistance enteric fever fluoroquinolone typhoid Adolescent Adult Anti-Bacterial Agents Azithromycin Ceftriaxone Child Drug Resistance Multiple Bacterial Female Fluoroquinolones Gatifloxacin Humans Male Microbial Sensitivity Tests Nepal Ofloxacin Paratyphoid Fever Salmonella paratyphi A Salmonella typhi Treatment Failure Treatment Outcome Typhoid Fever Young Adult
The global burden of typhoid and paratyphoid fevers
GBD 2017 Typhoid and Paratyphoid Collaborators
Apr 18, 2019
BACKGROUND: Efforts to quantify the global burden of enteric fever are valuable for understanding the health lost and the large-scale spatial distribution of the disease. We present the estimates of typhoid and paratyphoid fever...
Adolescent Adult Aged Aged 80 and over Cause of Death Child Child Preschool Disabled Persons Female Global Burden of Disease Humans Incidence Infant Life Expectancy Male Mass Vaccination Middle Aged Paratyphoid Fever Quality-Adjusted Life Years Risk Factors Salmonella enterica Sanitation Typhoid Fever Typhoid-Paratyphoid Vaccines Young Adult
Salmonella Paratyphi A Outer Membrane Vesicles Displaying Vi Polysaccharide as a Multivalent Vaccine against Enteric Fever.
G Gasperini, R Alfini, V Arato, F Mancini, MG Aruta, P Kanvatirth, D Pickard, F Necchi, A Saul, O Rossi, F Micoli, P Mastroeni
Dec 11, 2020
Paratype
Arif M Tanmoy, Yogesh Hooda, Mohammad SI Sajib, Kesia E da Silva, Junaid Iqbal, Farah N Qamar, Stephen P Luby, Gordon Dougan, Zoe A Dyson, Stephen Baker, Denise O Garrett, Jason R Andrews, Samir K Saha, Senjuti Saha
Jan 27, 2023
Salmonella Paratyphi A, the primary etiology of paratyphoid, is estimated to cause 3.4 million infections annually, worldwide. With rising antimicrobial resistance and no licensed vaccines, genomic surveillance is key to track...
A 23-year retrospective investigation of Salmonella Typhi and Salmonella Paratyphi isolated in a tertiary Kathmandu hospital.
Raphaël M Zellweger, Buddha Basnyat, Poojan Shrestha, Krishna G Prajapati, Sabina Dongol, Paban K Sharma, Samir Koirala, Thomas C Darton, Christiane Dolecek, Corinne N Thompson, Guy E Thwaites, Stephen G Baker, Abhilasha Karkey
Feb 19, 2019
BACKGROUND: Salmonella serovars Typhi (S. Typhi) and Paratyphi A (S. Paratyphi A), the causative agents of enteric fever, have been routinely isolated organisms from the blood of febrile patients in the Kathmandu Valley since...