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Guidelines on the use of liver biopsy in clinical practice from the British Society of Gastroenterology, the Royal College of Radiologists and the Royal College of Pathology.
James Neuberger, Jai Patel, Helen Caldwell, Susan Davies, Vanessa Hebditch, Coral Hollywood, Stefan Hubscher, Salil Karkhanis, Will Lester, Nicholas Roslund, Rebecca West, Judith I Wyatt, Mathis Heydtmann
Jun 03, 2020
Liver biopsy is required when clinically important information about the diagnosis, prognosis or management of a patient cannot be obtained by safer means, or for research purposes. There are several approaches to liver biopsy...
Histopathology interventional radiology liver biopsy Antibiotic Prophylaxis Anticoagulants Biopsy Blood Coagulation Tests Contraindications Procedure Endoscopic Ultrasound-Guided Fine Needle Aspiration Humans Informed Consent Interdisciplinary Communication laparoscopy Liver Needles Patient Selection Postoperative care Professional Role
Age-related inequalities in colon cancer treatment persist over time
Louise Hayes, Lynne Forrest, Jean Adams, Mira Hidajat, Yoav Ben-Shlomo, Martin White, Linda Sharp
Jun 12, 2020
BACKGROUND: Older people experience poorer outcomes from colon cancer. We examined if treatment for colon cancer was related to age and if inequalities changed over time. METHODS: Data from the UK population-based Northern and...
Deep brain stimulation for Tourette's syndrome.
Wenying Xu, Chencheng Zhang, Wissam Deeb, Bhavana Patel, Yiwen Wu, Valerie Voon, Michael S Okun, Bomin Sun
Mar 30, 2020
Tourette syndrome (TS) is a childhood-onset neuropsychiatric disorder characterized by the presence of multiple motor and vocal tics. TS usually co-occurs with one or multiple psychiatric disorders. Although behavioral and...
Managing uncertain recovery for patients nearing the end of life in hospital
J Koffman, E Yorganci, D Yi, W Gao, F Murtagh, A Pickles, S Barclay, H Johnson, R Wilson, L Sampson, J Droney, M Farquhar, T Prevost, CJ Evans
Aug 19, 2019
BACKGROUND: The AMBER (Assessment, Management, Best Practice, Engagement, Recovery Uncertain) care bundle is a complex intervention used in UK hospitals to support patients with uncertain recovery. However, it has yet to be...
AMBER care bundle feasibility study clinical trial clinical uncertainty complex intervention end-of-life care mixed methods Palliative Care Aged Aged 80 and over Cluster Analysis Feasibility Studies Female Humans Male Middle Aged Patient Care Bundles Patient Selection Prospective Studies Research Design Terminal Care uncertainty
The challenge of recruitment for neurotherapeutic clinical trials in spinal cord injury.
Andrew R Blight, Jane Hsieh, Armin Curt, James W Fawcett, James D Guest, Naomi Kleitman, Shekar N Kurpad, Brian K Kwon, Daniel P Lammertse, Norbert Weidner, John D Steeves
Aug 05, 2019
STUDY DESIGN: Narrative review by individuals experienced in the recruitment of participants to neurotherapeutic clinical trials in spinal cord injury (SCI). OBJECTIVES: To identify key problems of recruitment and explore...
New recommendations to reduce unnecessary blood tests after robot-assisted radical prostatectomy.
Arjun Nathan, Nancy Hanna, Amir Rashid, Sonam Patel, Yuzhi Phuah, Kiran Flora, Monty Fricker, Paul Cleaveland, Veeru Kasivisvanathan, Norman Williams, Saiful Miah, Justin Collins, Anand Kelkar, Ashwin Sridhar, John Hines, Tim Briggs, John Kelly, Nimish Shah, Greg Shaw, Prasanna Sooriakumaran, Prabhakar Rajan, Benjamin W Lamb, Senthil Nathan
Jul 07, 2021
blood tests complications Robot-assisted radical prostatectomy Aged Hematologic Tests Humans Male Middle Aged Patient Selection Postoperative care Postoperative Complications Practice Guidelines as Topic Prostatectomy Quality Improvement Retrospective Studies Robotic Surgical Procedures Unnecessary Procedures
The EU-AIMS Longitudinal European Autism Project (LEAP)
Eva Loth, Tony Charman, Luke Mason, Julian Tillmann, Emily JH Jones, Caroline Wooldridge, Jumana Ahmad, Bonnie Auyeung, Claudia Brogna, Sara Ambrosino, Tobias Banaschewski, Simon Baron-Cohen, Sarah Baumeister, Christian Beckmann, Michael Brammer, Daniel Brandeis, Sven Bölte, Thomas Bourgeron, Carsten Bours, Yvette de Bruijn, Bhismadev Chakrabarti, Daisy Crawley, Ineke Cornelissen, Flavio Dell' Acqua, Guillaume Dumas, Sarah Durston, Christine Ecker, Jessica Faulkner, Vincent Frouin, Pilar Garces, David Goyard, Hannah Hayward, Lindsay M Ham, Joerg Hipp, Rosemary Holt, Mark Johnson, Johan Isaksson, Prantik Kundu, Meng-Chuan Lai, Xavier Liogier D'ardhuy, Michael V Lombardo, David J Lythgoe, René Mandl, Andreas Meyer-Lindenberg, Carolin Moessnang, Nico Mueller, Laurence O'Dwyer, Marianne Oldehinkel, Bob Oranje, Gahan Pandina, Antonio M Persico, Amber Ruigrok, Barbara Ruggeri, Jessica Sabet, Roberto Sacco, Antonia San José Cáceres, Emily Simonoff, Roberto Toro, Heike Tost, Jack Waldman, Steve CR Williams, Marcel P Zwiers, Will Spooren, Declan GM Murphy, Jan K Buitelaar
Aug 18, 2017
Brain Saliva Hair Humans Magnetic Resonance Imaging Longitudinal Studies Individuality Siblings Phenotype Genetic Heterogeneity Patient Selection Adult Child Female Male Eye Movement Measurements Neuroimaging Biomarkers Autism spectrum disorder Precision Medicine
Published by: Molecular autism
Identification of pathologically insignificant prostate cancer is not accurate in unscreened men.
GL Shaw, BC Thomas, SN Dawson, G Srivastava, SL Vowler, VJ Gnanapragasam, NC Shah, AY Warren, DE Neal
Jun 11, 2018
BACKGROUND: Identification of men harbouring insignificant prostate cancer (PC) is important in selecting patients for active surveillance. Tools have been developed in PSA-screened populations to identify such men based on...
Adenocarcinoma Aged Area Under Curve Biopsy Needle Early Detection of Cancer False Negative Reactions Humans Lymphatic Metastasis Magnetic Resonance Imaging Male Middle Aged Neoplasm Grading Neoplasm Staging Organ Size Patient Selection Predictive Value of Tests Prostate Prostate-specific antigen Prostatic Neoplasms ROC Curve Retrospective Studies Risk Assessment Seminal vesicles Sensitivity and Specificity Tumor Burden Watchful Waiting
The cost-effectiveness of universal late-pregnancy screening for macrosomia in nulliparous women
D Wastlund, AA Moraitis, JG Thornton, J Sanders, IR White, P Brocklehurst, Gcs Smith, ECF Wilson
May 03, 2019
economic modelling health economics Macrosomia Pregnancy screening third-trimester ULTRASOUND Adult Cost-Benefit Analysis Decision Support Techniques England Female Fetal Macrosomia Health Services Research Humans Parity Patient Selection Pregnancy Pregnancy Trimester Third Prenatal Care Ultrasonography Prenatal
Moving towards more patient-centred clinical trials in IBD.
Declining recruitment rates in inflammatory bowel disease (IBD) trials have resulted in calls to modify the conduct of trials in IBD in order to make them more efficient and patient centred. Here, we propose a number of...
covid-19 Clinical Trials as Topic Humans Inflammatory Bowel Diseases Informed Consent Patient Acceptance of Health Care Patient Outcome Assessment Patient Reported Outcome Measures patient satisfaction Patient Selection Patient-Centered Care SARS-CoV-2 Self-testing Telemedicine Therapeutic Equipoise
The Edinburgh Addiction Cohort
John Macleod, Lorraine Copeland, Matthew Hickman, James McKenzie, Jo Kimber, Daniela De Angelis, James R Robertson
Jun 16, 2011
Adaptations to the British Society of Gastroenterology guidelines on the management of acute severe UC in the context of the COVID-19 pandemic
Shahida Din, Alexandra Kent, Richard C Pollok, Susanna Meade, Nicholas A Kennedy, Ian Arnott, R Mark Beattie, Felix Chua, Rachel Cooney, Robin J Dart, James Galloway, Daniel R Gaya, Subrata Ghosh, Mark Griffiths, Laura Hancock, Richard Hansen, Ailsa Hart, Christopher Andrew Lamb, Charlie W Lees, Jimmy K Limdi, James O Lindsay, Kamal Patel, Nick Powell, Charles D Murray, Chris Probert, Tim Raine, Christian Selinger, Shaji Sebastian, Philip J Smith, Phil Tozer, Andrew Ustianowski, Lisa Younge, Mark A Samaan, Peter M Irving
Jun 29, 2020
OBJECTIVE: Management of acute severe UC (ASUC) during the novel COVID-19 pandemic presents significant dilemmas. We aimed to provide COVID-19-specific guidance using current British Society of Gastroenterology (BSG) guidelines...
A multi-stage drop-the-losers design for multi-arm clinical trials.
Multi-arm multi-stage trials can improve the efficiency of the drug development process when multiple new treatments are available for testing. A group-sequential approach can be used in order to design multi-arm multi-stage...
Protocol for ADDITION-PRO
Nanna B Johansen, Anne-Louise S Hansen, Troels M Jensen, Annelotte Philipsen, Signe S Rasmussen, Marit E Jørgensen, Rebecca K Simmons, Torsten Lauritzen, Annelli Sandbæk, Daniel R Witte
Feb 27, 2013
Accelerated longitudinal designs
Laparoscopic adhesiolysis
Salomone Di Saverio, Arianna Birindelli, Richard Ten Broek, Justin R Davies, Matteo Mandrioli, Ville Sallinen
May 08, 2018
ASBO is a common cause of emergency surgery and the use of laparoscopy for the treatment of these patients is still under debate and conflicting results have been published, in particular regarding the high risk of iatrogenic...
Cost-effectiveness of personal tailored risk information and taster sessions to increase the uptake of the NHS stop smoking services
Qi Wu, Hazel Gilbert, Irwin Nazareth, Stephen Sutton, Richard Morris, Irene Petersen, Simon Galton, Steve Parrott
May 30, 2018
AIMS: To assess the cost-effectiveness of a two-component intervention designed to increase attendance at the NHS Stop Smoking Services (SSSs) in England. DESIGN: Cost-effectiveness analysis alongside a randomized controlled...
cost-effectiveness personal tailored risk information Randomized controlled trial Smoking Cessation stop smoking services uptake of service Cost-Benefit Analysis England general practitioners Humans Patient Education as Topic Patient Selection Quality-Adjusted Life Years risk Smoking Smoking Cessation State Medicine United Kingdom
The effects of releasing early results from ongoing clinical trials.
Steffen Ventz, Sergio Bacallado, Rifaquat Rahman, Sara Tolaney, Jonathan D Schoenfeld, Brian M Alexander, Lorenzo Trippa
Feb 05, 2021
Most trials do not release interim summaries on efficacy and toxicity of the experimental treatments being tested, with this information only released to the public after the trial has ended. While early release of clinical...
Protocol for the MoleMate UK Trial
Fiona M Walter, Helen C Morris, Elka Humphrys, Per N Hall, Ann Louise Kinmonth, A Toby Prevost, Edward Cf Wilson, Nigel Burrows, Paul Norris, Margaret Johnson, Jon Emery
Jun 16, 2011
Effectiveness of biomarker-based exclusion of ventilator-acquired pneumonia to reduce antibiotic use (VAPrapid-2)
Thomas P Hellyer, Niall H Anderson, Jennie Parker, Paul Dark, Tina Van Den Broeck, Suveer Singh, Ronan McMullan, Ashley M Agus, Lydia M Emerson, Bronagh Blackwood, Savita Gossain, Tim S Walsh, Gavin D Perkins, Andrew Conway Morris, Daniel F McAuley, A John Simpson
Jul 18, 2018
BACKGROUND: Ventilator-acquired pneumonia (VAP) is a common reason for antimicrobial therapy in the intensive care unit (ICU). Biomarker-based diagnostics could improve antimicrobial stewardship through rapid exclusion of VAP....
Antibiotic stewardship biomarker randomised controlled trial Ventilator-acquired pneumonia Anti-Bacterial Agents Antimicrobial Stewardship Bacteria Biomarkers Bronchoalveolar Lavage Fluid Clinical Protocols Colony Count Microbial Hospital Mortality Humans Interleukin-1beta Interleukin-8 Length of Stay Organ Dysfunction Scores Patient Selection Pneumonia Bacterial Pneumonia Ventilator-Associated Predictive Value of Tests Prospective Studies Research Design Respiration Artificial Time Factors United Kingdom Unnecessary Procedures
Response-adaptive designs for binary responses
Response-adaptive randomisation (RAR) can considerably improve the chances of a successful treatment outcome for patients in a clinical trial by skewing the allocation probability towards better performing treatments as data...
DELTA2 guidance on choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial.
Jonathan A Cook, Steven A Julious, William Sones, Lisa V Hampson, Catherine Hewitt, Jesse A Berlin, Deborah Ashby, Richard Emsley, Dean A Fergusson, Stephen J Walters, Edward Cf Wilson, Graeme MacLennan, Nigel Stallard, Joanne C Rothwell, Martin Bland, Louise Brown, Craig R Ramsay, Andrew Cook, David Armstrong, Doug Altman, Luke D Vale
Nov 07, 2018
Testing a peer support intervention for people with type 2 diabetes
David Simmons, Simon Cohn, Christopher Bunn, Kym Birch, Sarah Donald, Charlotte Paddison, Candice Ward, Peter Robins, A Toby Prevost, Jonathan Graffy
Jan 15, 2013
Control of hyperglycaemia in paediatric intensive care (CHiP)
Duncan Macrae, John Pappachan, Richard Grieve, Roger Parslow, Simon Nadel, Margrid Schindler, Paul Baines, Peter-Marc Fortune, Zdenek Slavik, Allan Goldman, Ann Truesdale, Helen Betts, Elizabeth Allen, Claire Snowdon, Deborah Percy, Michael Broadhead, Tara Quick, Mark Peters, Kevin Morris, Robert Tasker, Diana Elbourne
Jun 16, 2011
BACKGROUND: There is increasing evidence that tight blood glucose (BG) control improves outcomes in critically ill adults. Children show similar hyperglycaemic responses to surgery or critical illness. However it is not known...
Adolescent Age Factors Child Child Preschool Clinical Protocols Critical Illness Drug Monitoring England Humans Hyperglycemia Infant Infant Newborn Infusions Intravenous Insulin Intensive Care Units Pediatric Patient Selection Postoperative Complications Research Design Respiration Artificial Treatment Outcome Vasoconstrictor Agents Ventilator Weaning Wounds and Injuries
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