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Inhibition of Ras signalling has been a goal almost since its central role in cell signalling and its deregulation in disease were discovered. Early attempts at inhibiting its post-translational modification using...

G protein Macrocycle Peptidomimetic Ras Therapeutic Animals Drug Discovery Humans Monomeric GTP-Binding Proteins Multigene Family Peptides Protein Binding Protein Interaction Domains and Motifs Protein Transport Signal Transduction Son of Sevenless Proteins Structure-Activity Relationship ras Proteins