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G9a inhibition potentiates the anti-tumour activity of DNA double-strand break inducing agents by impairing DNA repair independent of p53 status.
Cancer epigenetics Chemical probes Chemotherapeutics Non-homologous end joining UNC0638 Antibiotics Antineoplastic Antineoplastic Combined Chemotherapy Protocols Apoptosis Cell Proliferation DNA Breaks Double-Stranded DNA End-Joining Repair Dose-Response Relationship Drug Enzyme Inhibitors Etoposide HCT116 Cells Histocompatibility Antigens Histone-Lysine N-Methyltransferase Humans Neoplasms Phleomycins Quinazolines RNA Interference Signal Transduction Time Factors Topoisomerase II Inhibitors Transfection Tumor Suppressor Protein p53