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Cortical actin recovery at the immunological synapse leads to termination of lytic granule secretion in cytotoxic T lymphocytes.
Alex T Ritter, Senta M Kapnick, Sricharan Murugesan, Pamela L Schwartzberg, Gillian M Griffiths, Jennifer Lippincott-Schwartz
Oct 10, 2018
CD8+ cytotoxic T lymphocytes (CTLs) eliminate virally infected cells through directed secretion of specialized lytic granules. Because a single CTL can kill multiple targets, degranulation must be tightly regulated. However, how...
Structure of the Toll/Interleukin-1 Receptor (TIR) Domain of the B-cell Adaptor That Links Phosphoinositide Metabolism with the Negative Regulation of the Toll-like Receptor (TLR) Signalosome
Arf6 promotes autophagosome formation via effects on phosphatidylinositol 4,5-bisphosphate and phospholipase D.
ADP-Ribosylation Factors Animals Autophagy Autophagy-Related Proteins Blotting Western CHO Cells Carrier Proteins Cell Membrane Cricetinae Endocytosis Endoplasmic Reticulum Fluorescent Antibody Technique GTPase-Activating Proteins Golgi Apparatus Green Fluorescent Proteins HeLa Cells Humans Immunosuppressive Agents Phagosomes Phosphatidylinositol 4 5-Diphosphate Phospholipase D Sirolimus TOR Serine-Threonine Kinases
In vivo tracking of phosphoinositides in Drosophila photoreceptors.
Fluorescent probes GFP PIP2 Phototransduction Pleckstrin homology domain Voltage-sensitive phosphatase Animals Calcium Diacylglycerol Kinase Drosophila Proteins Drosophila melanogaster Eye Proteins Membrane Proteins Phosphatidylinositol 4 5-Diphosphate Photoreceptor Cells Invertebrate Protein Kinase C
Autophagosome-lysosome fusion triggers a lysosomal response mediated by TLR9 and controlled by OCRL.
Maria Giovanna De Leo, Leopoldo Staiano, Mariella Vicinanza, Alessandro Luciani, Annamaria Carissimo, Margherita Mutarelli, Antonella Di Campli, Elena Polishchuk, Giuseppe Di Tullio, Valentina Morra, Elena Levtchenko, Francesca Oltrabella, Tobias Starborg, Michele Santoro, Diego di Bernardo, Olivier Devuyst, Martin Lowe, Diego L Medina, Andrea Ballabio, Maria Antonietta De Matteis
Sep 03, 2019
Phosphoinositides (PtdIns) control fundamental cell processes, and inherited defects of PtdIns kinases or phosphatases cause severe human diseases, including Lowe syndrome due to mutations in OCRL, which encodes a PtdIns(4,5)P2...
The Vesicle Priming Factor CAPS Functions as a Homodimer via C2 Domain Interactions to Promote Regulated Vesicle Exocytosis.
Matt Petrie, Joseph Esquibel, Greg Kabachinski, Stephanie Maciuba, Hirohide Takahashi, J Michael Edwardson, Thomas FJ Martin
Sep 20, 2018
Neurotransmitters and peptide hormones are secreted by regulated vesicle exocytosis. CAPS (also known as CADPS) is a 145-kDa cytosolic and peripheral membrane protein required for vesicle docking and priming steps that precede...