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Slowing of fetal growth and elevated maternal serum sFLT1
fetal growth fetal stress Placental Insufficiency Pregnancy protein biomarkers spontaneous labor Adult Biomarkers Cohort Studies Female Fetal Development Gestational Age Humans Labor Obstetric Placenta Growth Factor Placental Insufficiency Pregnancy Ultrasonography Prenatal Vascular Endothelial Growth Factor Receptor-1
Pathophysiology of placental-derived fetal growth restriction.
Placental-related fetal growth restriction arises primarily due to deficient remodeling of the uterine spiral arteries supplying the placenta during early pregnancy. The resultant malperfusion induces cell stress within the...
AKT/mTOR Apoptosis atherosis chorion laeve electron transport chain extravillous trophoblast failure of physiologic transformation fetal growth restriction fetoplacental weight ratio Hemochorial placentation interstitial trophoblast intervillous space intraplacental oxygen concentration Mitochondria Oxidative Stress perivillous fibrin deposition Placenta placental infarct placental inflammation placental location Reactive Oxygen Species spiral arteries ultrasound imaging Unfolded Protein Response villi regression villous hypoplasia Chorionic Villi Female Fetal Growth Retardation Gene Expression Regulation Genomic Imprinting Humans Magnetic Resonance Imaging Maternal-Fetal Exchange Placenta Placental Circulation Placental Insufficiency Placentation pre-eclampsia Pregnancy Stress Physiological Trophoblasts Ultrasonography Prenatal Umbilical Arteries Uterine Artery Vascular Remodeling
Circulating SPINT1 is a biomarker of pregnancies with poor placental function and fetal growth restriction.
Tu'uhevaha J Kaitu'u-Lino, Teresa M MacDonald, Ping Cannon, Tuong-Vi Nguyen, Richard J Hiscock, Nick Haan, Jenny E Myers, Roxanne Hastie, Kirsten M Dane, Anna L Middleton, Intissar Bittar, Amanda N Sferruzzi-Perri, Natasha Pritchard, Alesia Harper, Natalie J Hannan, Valerie Kyritsis, Nick Crinis, Lisa Hui, Susan P Walker, Stephen Tong
Jul 17, 2020
Placental insufficiency can cause fetal growth restriction and stillbirth. There are no reliable screening tests for placental insufficiency, especially near-term gestation when the risk of stillbirth rises. Here we show a...
Animals Anthropometry Biomarkers Female Fetal Growth Retardation Humans Infant Newborn Infant Small for Gestational Age Mice Placenta Placental Insufficiency Plethysmography Predictive Value of Tests Pregnancy Pregnancy Trimester Third Proteinase Inhibitory Proteins Secretory Sensitivity and Specificity Ultrasonography Prenatal Umbilical Arteries Uterine Artery