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Results: 5
Ethaninidothioic acid (R5421) is not a selective inhibitor of platelet phospholipid scramblase activity.
Sarah Louise Millington-Burgess, Arkadiusz M Bonna, Taufiq Rahman, Matthew Thomas Harper
May 27, 2020
Activated αIIbβ3 on platelets mediates flow-dependent NETosis via SLC44A2.
Adela Constantinescu-Bercu, Luigi Grassi, Mattia Frontini, Isabelle I Salles-Crawley, Kevin Woollard, James Tb Crawley
May 28, 2020
Platelet-neutrophil interactions are important for innate immunity, but also contribute to the pathogenesis of deep vein thrombosis, myocardial infarction and stroke. Here we report that, under flow, von Willebrand...
Absence of platelet phenotype in mice lacking the motor protein myosin Va.
BACKGROUND: The motor protein myosin Va plays an important role in the trafficking of intracellular vesicles. Mutation of the Myo5a gene causes Griscelli syndrome type 1 in humans and the dilute phenotype in mice, which are both...
A mutation of the human EPHB2 gene leads to a major platelet functional defect.
Eliane Berrou, Christelle Soukaseum, Rémi Favier, Frédéric Adam, Ziane Elaib, Alexandre Kauskot, Jean-Claude Bordet, Paola Ballerini, Stephane Loyau, Miao Feng, Karine Dias, Abbas Muheidli, Stephane Girault, Alan T Nurden, Ernest Turro, Willem H Ouwehand, Cécile V Denis, Martine Jandrot-Perrus, Jean-Philippe Rosa, Paquita Nurden, Marijke Bryckaert
Nov 22, 2018
The ephrin transmembrane receptor family of tyrosine kinases is involved in platelet function. We report the first EPHB2 variant affecting platelets in 2 siblings (P1 and P2) from a consanguineous family with recurrent bleeding...
Platelet collagen receptor Glycoprotein VI-dimer recognizes fibrinogen and fibrin through their D-domains, contributing to platelet adhesion and activation during thrombus formation.
I Induruwa, M Moroi, A Bonna, J-D Malcor, J-M Howes, EA Warburton, RW Farndale, SM Jung
Feb 09, 2018
UNLABELLED: Essentials Glycoprotein VI (GPVI) binds collagen, starting thrombogenesis, and fibrin, stabilizing thrombi. GPVI-dimers, not monomers, recognize immobilized fibrinogen and fibrin through their D-domains. Collagen...
Fibrin fibrin fragment D-dimer fibrinogen fragment D platelet membrane glycoprotein VI Platelet Membrane Glycoproteins Receptors Collagen Binding Sites Blood Platelets Case-Control Studies Collagen Fibrin Fibrin Fibrinogen Degradation Products Fibrinogen Humans Platelet Activation Platelet Adhesiveness Platelet Glycoprotein GPIIb-IIIa Complex Platelet Membrane Glycoproteins Protein Binding Protein Interaction Domains and Motifs Protein Multimerization Signal Transduction Structure-Activity Relationship Thrombasthenia Thrombosis