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Results: 43
High Structural Stress and Presence of Intraluminal Thrombus Predict Abdominal Aortic Aneurysm 18F-FDG Uptake
Yuan Huang, Zhongzhao Teng, Maysoon Elkhawad, Jason M Tarkin, Nikhil Joshi, Jonathan R Boyle, John R Buscombe, Timothy D Fryer, Yongxue Zhang, Ah Yeon Park, Ian B Wilkinson, David E Newby, Jonathan H Gillard, James HF Rudd
Nov 10, 2016
abdominal aortic aneurysm Fluorodeoxyglucose F18 Inflammation mechanical stress Positron-Emission Tomography Thrombosis Aged Aged 80 and over Aorta Abdominal Aortic Aneurysm Abdominal Aortic Rupture Aortitis Aortography Biomechanical Phenomena Computed Tomography Angiography Female Finite element analysis Fluorodeoxyglucose F18 Humans Linear Models Male Middle Aged Multivariate Analysis Positron Emission Tomography Computed Tomography Predictive Value of Tests Prognosis Pulsatile Flow Radiographic Image Interpretation Computer-Assisted Radiopharmaceuticals Regional Blood Flow Risk Factors Stress Mechanical Thrombosis Vascular Calcification
Hypoxia and tissue destruction in pulmonary TB.
Moerida Belton, Sara Brilha, Roido Manavaki, Francesco Mauri, Kuldip Nijran, Young T Hong, Neva H Patel, Marcin Dembek, Liku Tezera, Justin Green, Rachel Moores, Franklin Aigbirhio, Adil Al-Nahhas, Tim D Fryer, Paul T Elkington, Jon S Friedland
Jun 03, 2016
Tuberculosis Adult Biopsy Cell Hypoxia Cells Cultured Collagenases Epithelial Cells Female Gene Expression Regulation Humans Hypoxia-Inducible Factor 1 alpha Subunit Lung MACROPHAGES Male Matrix Metalloproteinase 1 Microscopy Confocal Middle Aged Mycobacterium tuberculosis Positron Emission Tomography Computed Tomography RNA Messenger Respiratory Mucosa Tuberculosis Pulmonary Up-Regulation Young Adult
11C-metomidate PET-CT scanning can identify aldosterone-producing adenomas after unsuccessful lateralisation with CT/MRI and adrenal venous sampling.
Primary hyperaldosteronism, characterised by hypertension and hypokalaemia, is a syndrome caused by aldosterone excess most commonly from either a unilateral aldosterone-producing adenoma or bilateral adrenal hyperplasia....
Standardized Index of Shape (DCE-MRI) and Standardized Uptake Value (PET/CT)
Antonella Petrillo, Roberta Fusco, Mario Petrillo, Vincenza Granata, Paolo Delrio, Francesco Bianco, Biagio Pecori, Gerardo Botti, Fabiana Tatangelo, Corradina Caracò, Luigi Aloj, Antonio Avallone, Secondo Lastoria
May 03, 2019
PURPOSE: To investigate dynamic contrast enhanced-MRI (DCE-MRI) in the preoperative chemo-radiotherapy (CRT) assessment for locally advanced rectal cancer (LARC) compared to18F-fluorodeoxyglucose positron emission...
DCE-MRI and FDG-PET/CT neoadjuvant chemo-radiotherapy rectal cancer treatment response assessment Adult Aged Area Under Curve Chemoradiotherapy Adjuvant Contrast Media Digestive System Surgical Procedures Female Fluorodeoxyglucose F18 Humans Magnetic Resonance Imaging Magnetite Nanoparticles Male Middle Aged Neoadjuvant Therapy Perfusion Imaging Positron Emission Tomography Computed Tomography Predictive Value of Tests ROC Curve Radiopharmaceuticals Rectal Neoplasms Regional Blood Flow Remission Induction Reproducibility of Results Siloxanes Treatment Outcome
Over-activation of primate subgenual cingulate cortex enhances the cardiovascular, behavioral and neural responses to threat.
Laith Alexander, Christian M Wood, Philip LR Gaskin, Stephen J Sawiak, Tim D Fryer, Young T Hong, Lauren McIver, Hannah F Clarke, Angela C Roberts
Oct 02, 2020
Stress-related disorders such as depression and anxiety are characterized by enhanced negative emotion and physiological dysfunction. Whilst elevated activity within area 25 of the subgenual anterior cingulate cortex (sgACC/25)...
Systematically evaluating DOTATATE and FDG as PET immuno-imaging tracers of cardiovascular inflammation.
Yohana C Toner, Adam A Ghotbi, Sonum Naidu, Ken Sakurai, Mandy MT van Leent, Stefan Jordan, Farideh Ordikhani, Letizia Amadori, Alexandros Marios Sofias, Elizabeth L Fisher, Alexander Maier, Nathaniel Sullivan, Jazz Munitz, Max L Senders, Christian Mason, Thomas Reiner, Georgios Soultanidis, Jason M Tarkin, James HF Rudd, Chiara Giannarelli, Jordi Ochando, Carlos Pérez-Medina, Andreas Kjaer, Willem JM Mulder, Zahi A Fayad, Claudia Calcagno
May 15, 2022
PET-guided repeat transsphenoidal surgery for previously deemed unresectable lateral disease in acromegaly.
Waiel A Bashari, Russell Senanayake, Olympia Koulouri, Daniel Gillett, James MacFarlane, Andrew S Powlson, Antia Fernandez-Pombo, Gul Bano, Andrew J Martin, Daniel Scoffings, Heok Cheow, Iosif Mendichovszky, James Tysome, Neil Donnelly, Thomas Santarius, Angelos Kolias, Richard Mannion, Mark Gurnell
Jun 23, 2020
DA = dopamine agonist FSPGR = fast spoiled gradient-recalled echo GH = growth hormone IGF-1 = insulin-like growth factor 1 MDT = multidisciplinary team Met-PET = PET using 11C-methionine Met-PET/MRCR Met-PET/MRCR = Met-PET coregistered with volumetric MRI PA = pituitary adenoma RT = radiotherapy SSA = somatostatin analog TSS = transsphenoidal surgery ULN = upper limit of normal acromegaly extended TSS lateral parasellar acromegaly Adult Aged Female Humans Male Middle Aged Positron Emission Tomography Computed Tomography Proof of Concept Study Reoperation Sphenoid Bone
Pattern of arterial inflammation and inflammatory markers in people living with HIV compared with uninfected people.
Nevio Taglieri, Rachele Bonfiglioli, Isabella Bon, Pietro Malosso, Andrej Corovic, Matteo Bruno, Elizabeth Le, Bianca Granozzi, Tullio Palmerini, Gabriele Ghetti, Martina Tamburello, Antonio Giulio Bruno, Francesco Saia, Jason M Tarkin, James HF Rudd, Leonardo Calza, Stefano Fanti, Maria Carla Re, Nazzareno Galié
Aug 03, 2022
18F-fluorodeoxyglucose-positron emission tomography Arterial inflammation HIV Arteritis Atherosclerosis Biomarkers Fluorodeoxyglucose F18 HIV Infections Humans Inflammation Positron Emission Tomography Computed Tomography Radiopharmaceuticals Tomography X-Ray Computed Vascular Cell Adhesion Molecule-1
An Automated Method for Artifical Intelligence Assisted Diagnosis of Active Aortitis Using Radiomic Analysis of FDG PET-CT Images.
Lisa M Duff, Andrew F Scarsbrook, Nishant Ravikumar, Russell Frood, Gijs D van Praagh, Sarah L Mackie, Marc A Bailey, Jason M Tarkin, Justin C Mason, Kornelis SM van der Geest, Riemer HJA Slart, Ann W Morgan, Charalampos Tsoumpas
Mar 06, 2023
Low-dose interleukin 2 for the reduction of vascular inflammation in acute coronary syndromes (IVORY)
Rouchelle Sriranjan, Tian Xiao Zhao, Jason Tarkin, Annette Hubsch, Joanna Helmy, Evangelia Vamvaka, Navazh Jalaludeen, Simon Bond, Stephen P Hoole, Philip Knott, Samantha Buckenham, Victoria Warnes, Nick Bird, Heok Cheow, Heike Templin, Paul Cacciottolo, James HF Rudd, Ziad Mallat, Joseph Cheriyan
Nov 07, 2022
Cardiology cardiovascular imaging Clinical Trials immunology Acute Coronary Syndrome Atherosclerosis C-Reactive Protein Clinical Trials Phase II as Topic Coronary Artery Disease Double-Blind Method Fluorodeoxyglucose F18 Glucose Humans Inflammation Interleukin-2 Myocardial Infarction Myocardial Ischemia Positron Emission Tomography Computed Tomography Randomized Controlled Trials as Topic Treatment Outcome
Thyroid and androgen receptor signaling are antagonized by μ-Crystallin in prostate cancer.
Osman Aksoy, Jan Pencik, Markus Hartenbach, Ali A Moazzami, Michaela Schlederer, Theresa Balber, Adam Varady, Cecile Philippe, Pascal A Baltzer, Bismoy Mazumder, Jonathan B Whitchurch, Christopher J Roberts, Andrea Haitel, Merima Herac, Martin Susani, Markus Mitterhauser, Rodrig Marculescu, Judith Stangl-Kremser, Melanie R Hassler, Gero Kramer, Shahrokh F Shariat, Suzanne D Turner, Boris Tichy, Jan Oppelt, Sarka Pospisilova, Sabrina Hartenbach, Simone Tangermann, Gerda Egger, Heidi A Neubauer, Richard Moriggl, Zoran Culig, Georg Greiner, Gregor Hoermann, Marcus Hacker, David M Heery, Olaf Merkel, Lukas Kenner
Sep 03, 2020
Androgen deprivation therapy (ADT) remains a key approach in the treatment of prostate cancer (PCa). However, PCa inevitably relapses and becomes ADT resistant. Besides androgens, there is evidence that thyroid hormone thyroxine...
PSMA-PET Androgen receptor prostate cancer thyroid hormone receptor μ-Crystallin Cell Line Tumor Choline Cohort Studies Crystallins Down-Regulation Gene Expression Profiling Gene Expression Regulation Neoplastic Humans Male Metabolomics Neoplasm Staging PC-3 Cells Positron Emission Tomography Computed Tomography Prognosis Prostatic Neoplasms Receptors Androgen Receptors Thyroid Hormone Sequence Analysis RNA Signal Transduction Tissue Array Analysis Triiodothyronine mu-Crystallins
Synergistic application of pulmonary 18F-FDG PET/HRCT and computer-based CT analysis with conventional severity measures to refine current risk stratification in idiopathic pulmonary fibrosis (IPF).
Francesco Fraioli, Maria Lyasheva, Joanna C Porter, Jamshed Bomanji, Robert I Shortman, Raymond Endozo, Simon Wan, Linda Bertoletti, Maria Machado, Balaji Ganeshan, Thida Win, Ashley M Groves
Jul 07, 2020
INTRODUCTION: To investigate the combined performance of quantitative CT (qCT) following a computer algorithm analysis (IMBIO) and 18F-FDG PET/CT to assess survival in patients with idiopathic pulmonary fibrosis (IPF). METHODS...
Fluorine-18 FDG and pulmonary vessels Idiopathic Pulmonary Fibrosis positron emission tomography Quantitative computer analysis Aged Aged 80 and over Female Fluorodeoxyglucose F18 Humans Image Processing Computer-Assisted Male Middle Aged Positron Emission Tomography Computed Tomography Predictive Value of Tests pulmonary fibrosis Radiopharmaceuticals Survival Analysis
Sequential PET/CT with [18F]-FDG Predicts Pathological Tumor Response to Preoperative Short Course Radiotherapy with Delayed Surgery in Patients with Locally Advanced Rectal Cancer Using Logistic Regression Analysis.
Biagio Pecori, Secondo Lastoria, Corradina Caracò, Marco Celentani, Fabiana Tatangelo, Antonio Avallone, Daniela Rega, Giampaolo De Palma, Maria Mormile, Alfredo Budillon, Paolo Muto, Francesco Bianco, Luigi Aloj, Antonella Petrillo, Paolo Delrio
Dec 18, 2018
UNLABELLED: Previous studies indicate that FDG PET/CT may predict pathological response in patients undergoing neoadjuvant chemo-radiotherapy for locally advanced rectal cancer (LARC). Aim of the current study is evaluate if...
Integrated Pharmacodynamic Analysis Identifies Two Metabolic Adaption Pathways to Metformin in Breast Cancer.
Simon R Lord, Wei-Chen Cheng, Dan Liu, Edoardo Gaude, Syed Haider, Tom Metcalf, Neel Patel, Eugene J Teoh, Fergus Gleeson, Kevin Bradley, Simon Wigfield, Christos Zois, Daniel R McGowan, Mei-Lin Ah-See, Alastair M Thompson, Anand Sharma, Luc Bidaut, Michael Pollak, Pankaj G Roy, Fredrik Karpe, Tim James, Ruth English, Rosie F Adams, Leticia Campo, Lisa Ayers, Cameron Snell, Ioannis Roxanis, Christian Frezza, John D Fenwick, Francesca M Buffa, Adrian L Harris
Nov 21, 2018
Late-phase clinical trials investigating metformin as a cancer therapy are underway. However, there remains controversy as to the mode of action of metformin in tumors at clinical doses. We conducted a clinical study integrating...
Breast Neoplasms cancer metabolism clinical study Gene Expression Profiling Metabolomics Metformin Mitochondria positron emission tomography Adult Aged Antineoplastic Agents Breast Neoplasms Female Gene Expression Regulation Neoplastic Glucose Humans Hypoglycemic Agents Metabolic Networks and Pathways Metformin Middle Aged Mitochondria Positron Emission Tomography Computed Tomography Transcriptome
Pulmonary 18F-FDG uptake helps refine current risk stratification in idiopathic pulmonary fibrosis (IPF).
Thida Win, Nicholas J Screaton, Joanna C Porter, Balaji Ganeshan, Toby M Maher, Francesco Fraioli, Raymondo Endozo, Robert I Shortman, Lynn Hurrell, Beverley F Holman, Kris Thielemans, Alaleh Rashidnasab, Brian F Hutton, Pauline T Lukey, Aiden Flynn, Peter J Ell, Ashley M Groves
Sep 21, 2018
PURPOSE: There is a lack of prognostic biomarkers in idiopathic pulmonary fibrosis (IPF) patients. The objective of this study is to investigate the potential of 18F-FDG-PET/ CT to predict mortality in IPF. METHODS: A total of...
Fluorine-18 FDG Interstitial lung disease Positron-emission tomography and computed tomography Aged Female Fluorodeoxyglucose F18 Humans Idiopathic Pulmonary Fibrosis Lung Male Middle Aged Positron Emission Tomography Computed Tomography Positron-Emission Tomography Risk Assessment Tomography X-Ray Computed
Cardiac decompensation revealing giant cell arteritis.
Karl Emil Nelveg-Kristensen, Anouk Le Goueff, Rona M Smith, Kevin Loudon, Allyson C Egan, David RW Jayne
Nov 22, 2021
Cardiac decompensation revealing giant cell arteritis.
Whole-body and adipose tissue-specific mechanisms underlying the metabolic effects of fibroblast growth factor 21 in the Siberian hamster.
Jo E Lewis, Chloe Monnier, Hayley Marshall, Maxine Fowler, Rebecca Green, Scott Cooper, Aristeidis Chiotellis, Jeni Luckett, Alan C Perkins, Tamer Coskun, Andrew C Adams, Ricardo J Samms, Francis JP Ebling, Kostas Tsintzas
Feb 10, 2020
OBJECTIVE: Fibroblast growth factor 21 (FGF21) has been shown to rapidly lower body weight in the Siberian hamster, a preclinical model of adiposity. This induced negative energy balance mediated by FGF21 is associated with both...
Multimodal Imaging of Granulomatosis With Polyangiitis Aortitis Complicated by Severe Aortic Regurgitation and Complete Heart Block.
Jason M Tarkin, Graham D Cole, Deepa Gopalan, Rashpal Flora, Stephen P McAdoo, Justin C Mason, Nicholas S Peters, Charles D Pusey, Amanda Varnava
Oct 04, 2019
A 38-year-old man presented with exertional dyspnea and dizziness. Six months earlier, he had attended the Emergency Department following a brief syncopal episode while exercising. There were no constitutional symptoms, and no...
Aortic Valve Aortitis heart block Inflammation Tomography Adult Aortic Valve Aortic Valve Insufficiency Aortitis Cardiac Surgical Procedures Computed Tomography Angiography Diagnosis Differential Echocardiography Doppler Color Electrocardiography Granulomatosis with polyangiitis Heart Block Humans Magnetic Resonance Imaging Cine Male Multimodal Imaging Positron Emission Tomography Computed Tomography
11 C-Metomidate PET/CT is a useful adjunct for lateralization of primary aldosteronism in routine clinical practice.
Paula M O'Shea, Darragh O'Donoghue, Waiel Bashari, Russell Senanayake, Mary B Joyce, Andrew S Powlson, Darragh Browne, Gerard J O'Sullivan, Heok Cheow, Iosif Mendichovszky, Denis Quill, Aoife Lowery, David Lappin, Mark Gurnell, Michael C Dennedy
Apr 05, 2019
OBJECTIVE: To describe clinical practice experience of 11 C-Metomidate PET/CT as an adjunct to adrenal vein sampling (AVS) in the lateralization of aldosterone-producing adenomas (APA) in primary aldosteronism (PA). CONTEXT...
Detection and Prediction of Bioprosthetic Aortic Valve Degeneration.
Timothy RG Cartlidge, Mhairi K Doris, Stephanie L Sellers, Tania A Pawade, Audrey C White, Renzo Pessotto, Jacek Kwiecinski, Alison Fletcher, Carlos Alcaide, Christophe Lucatelli, Cameron Densem, James HF Rudd, Edwin JR van Beek, Adriana Tavares, Renu Virmani, Daniel Berman, Jonathon A Leipsic, David E Newby, Marc R Dweck
Mar 25, 2019
BACKGROUND: Bioprosthetic aortic valve degeneration is increasingly common, often unheralded, and can have catastrophic consequences. OBJECTIVES: The authors sought to assess whether 18F-fluoride positron emission tomography...
aortic valve replacement bioprosthetic valve degeneration calcification Histology positron emission tomography Aged Aortic Valve Aortic Valve Insufficiency aortic valve stenosis Bioprosthesis Calcinosis Computed Tomography Angiography Echocardiography Female Fluorodeoxyglucose F18 Heart valve prosthesis Humans Male Positron Emission Tomography Computed Tomography Postoperative Complications Predictive Value of Tests Prognosis prosthesis failure Radiopharmaceuticals
Evaluation of [18F]-FDG-Based Hybrid Imaging Combinations for Assessment of Bone Marrow Involvement in Lymphoma at Initial Staging.
Ulrika Asenbaum, Richard Nolz, Georgios Karanikas, Julia Furtner, Ramona Woitek, Anton Staudenherz, Daniela Senn, Markus Raderer, Michael Weber, Ingrid Simonitsch-Klupp, Marius E Mayerhoefer
Dec 20, 2018
The purpose of our study was to determine the value of different hybrid imaging combinations for the detection of focal and diffuse bone marrow infiltration in lymphoma. Patients with histologically proven lymphoma, who...
Adult Aged Aged 80 and over Bone Marrow False Negative Reactions Female Fluorodeoxyglucose F18 Humans Image Processing Computer-Assisted Lymphoma Magnetic Resonance Imaging Male Middle Aged Neoplasm Staging Positron Emission Tomography Computed Tomography Radiopharmaceuticals Retrospective Studies Sensitivity and Specificity Whole Body Imaging Young Adult
Native Aortic Valve Disease Progression and Bioprosthetic Valve Degeneration in Patients With Transcatheter Aortic Valve Implantation.
Jacek Kwiecinski, Evangelos Tzolos, Timothy RG Cartlidge, Alexander Fletcher, Mhairi K Doris, Rong Bing, Jason M Tarkin, Michael A Seidman, Gaurav S Gulsin, Nicholas L Cruden, Anna K Barton, Neal G Uren, Michelle C Williams, Edwin JR van Beek, Jonathon Leipsic, Damini Dey, Raj R Makkar, Piotr J Slomka, James HF Rudd, David E Newby, Stephanie L Sellers, Daniel S Berman, Marc R Dweck
Sep 15, 2021
BACKGROUND: Major uncertainties remain regarding disease activity within the retained native aortic valve, and regarding bioprosthetic valve durability, after transcatheter aortic valve implantation (TAVI). We aimed to assess...
18F-sodium fluoride Aortic Valve Positron Emission Tomography Computed Tomography transcatheter aortic valve implantation Aged Aged 80 and over aortic valve disease Cohort Studies Cross-Sectional Studies Disease Progression Female Heart valve prosthesis Humans Male transcatheter aortic valve replacement
Functional localization and categorization of intentional decisions in humans
Brain-imaging research on intentional decision-making often employs a "free-choice" paradigm, in which participants choose among options with identical values or outcomes. Although the medial prefrontal cortex has commonly been...
Implementation of functional imaging using 11C-methionine PET-CT co-registered with MRI for advanced surgical planning and decision making in prolactinoma surgery.
Leontine EH Bakker, Marco JT Verstegen, Eidrees Ghariq, Berit M Verbist, Pieter J Schutte, Waiel A Bashari, Mark C Kruit, Alberto M Pereira, Mark Gurnell, Nienke R Biermasz, Wouter R Van Furth, Lenka M Pereira Arias Bouda
Aug 02, 2022
PURPOSE: To report the first experience of our multidisciplinary team with functional imaging using 11C-methionine positron emission tomography-computed tomography (11C-methionine PET-CT) co-registered with MRI (Met-PET/MRICR)...
Dopamine agonist intolerance functional imaging positron emission tomography Prolactinoma Surgical decision making Transsphenoidal surgery Decision Making Humans Magnetic Resonance Imaging Methionine Pituitary Neoplasms Positron Emission Tomography Computed Tomography Positron-Emission Tomography Prolactinoma Retrospective Studies
First-in-human evaluation of [18F]CETO
Isabella Silins, Anders Sundin, Mark Lubberink, Lleah O'Sullivan, Mark Gurnell, Franklin Aigbirhio, Morris Brown, Anders Wall, Tobias Åkerström, Sara Roslin, Per Hellman, Gunnar Antoni
Jan 05, 2023
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