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Results: 19
Improvement over time in outcomes for patients undergoing endoscopic therapy for Barrett's oesophagus-related neoplasia
RJ Haidry, MA Butt, JM Dunn, A Gupta, G Lipman, HL Smart, P Bhandari, L Smith, R Willert, G Fullarton, M di Pietro, C Gordon, I Penman, H Barr, P Patel, N Kapoor, J Hoare, R Narayanasamy, Y Ang, A Veitch, K Ragunath, M Novelli, LB Lovat, UK RFA Registry
Aug 20, 2020
BACKGROUND: Barrett's oesophagus (BE) is a pre-malignant condition leading to oesophageal adenocarcinoma (OAC). Treatment of neoplasia at an early stage is desirable. Combined endoscopic mucosal resection (EMR) followed by...
BARRETT'S OESOPHAGUS ENDOSCOPIC PROCEDURES OESOPHAGEAL CANCER Adenocarcinoma Adult Aged Aged 80 and over Barrett Esophagus Catheter Ablation Disease Progression Esophageal Neoplasms Esophagoscopy Female Follow-Up Studies Humans Male Middle Aged Precancerous Conditions Prospective Studies Registries Time Factors Treatment Outcome United Kingdom
The risk of neoplasia in patients with Barrett's esophagus indefinite for dysplasia
Richard Phillips, Wladyslaw Januszewicz, Nastazja D Pilonis, Maria O'Donovan, Tarek Sawas, David A Katzka, Rebecca C Fitzgerald, Massimiliano di Pietro
Feb 19, 2021
Cervical cell lift
Aslam Shiraz, Nagayasu Egawa, Daniël M Pelt, Robin Crawford, Adeline K Nicholas, Veronika Romashova, Peter Sasieni, Heather Griffin, John Doorbar
Aug 21, 2022
BACKGROUND: Primary HPV screening, due to its low specificity, requires an additional liquid-based cytology (LBC) triage test. However, even with LBC triage there has been a near doubling in the number of patients referred for...
Biomarker for cervical screening CIN Cervical cancer Cytology HPV Methodology for cervical screening Non-invasive sampling Spatial mapping of lesion Triage test Cervix Uteri Early Detection of Cancer Female Humans Papillomaviridae Papillomavirus Infections Pilot Projects Precancerous Conditions Triage Uterine Cervical Neoplasms Vaginal Smears Uterine Cervical Dysplasia
Design and validation of a near-infrared fluorescence endoscope for detection of early esophageal malignancy.
Dale J Waterhouse, James Joseph, André A Neves, Massimiliano di Pietro, Kevin M Brindle, Rebecca C Fitzgerald, Sarah E Bohndiek
Aug 23, 2016
Minimally invasive esophageal sponge cytology sampling is feasible in a Tanzanian community setting.
Daniel RS Middleton, Blandina T Mmbaga, Maria O'Donovan, Behnoush Abedi-Ardekani, Irene Debiram-Beecham, Gissela Nyakunga-Maro, Venance Maro, Martin Bromwich, Amini Daudi, Timothy Ngowi, Rehema Minde, Jackson Claver, Alex Mremi, Amos Mwasamwaja, Joachim Schüz, Rebecca C Fitzgerald, Valerie McCormack
Feb 16, 2021
Esophageal sponge cytology is an endoscopy alternative well accepted by patients with extensive data for accuracy in the context of adenocarcinoma. Few studies have assessed its feasibility in asymptomatic community members, and...
Endoscopist biopsy rate as a quality indicator for outpatient gastroscopy
Wladyslaw Januszewicz, Paulina Wieszczy, Andrzej Bialek, Katarzyna Karpinska, Jakub Szlak, Jakub Szymonik, Maciej Rupinski, Andrzej Mroz, Jaroslaw Regula, Michal F Kaminski
Nov 27, 2019
BACKGROUND AND AIMS: The diagnosis of gastric premalignant conditions (GPCs) relies on endoscopy with mucosal sampling. We hypothesized that the endoscopist biopsy rate (EBR) might constitute a quality indicator for EGD, and we...
Adenoma Adolescent Adult Aged Ambulatory Care Barrett Esophagus Biopsy Cohort Studies Duodenal Neoplasms Female Gastritis Atrophic Gastroscopy Humans Information Storage and Retrieval Logistic Models Male Metaplasia Middle Aged Multivariate Analysis Poland Precancerous Conditions Quality Indicators Health Care Retrospective Studies Squamous Intraepithelial Lesions Stomach Stomach Neoplasms Young Adult
Eva M Serrao, Mikko I Kettunen, Tiago B Rodrigues, Piotr Dzien, Alan J Wright, Aarthi Gopinathan, Ferdia A Gallagher, David Y Lewis, Kristopher K Frese, Jaime Almeida, William J Howat, David A Tuveson, Kevin M Brindle
Aug 07, 2015
Timeline and location of recurrence following successful ablation in Barrett's oesophagus
Sarmed S Sami, Adharsh Ravindran, Allon Kahn, Diana Snyder, Jose Santiago, Jacobo Ortiz-Fernandez-Sordo, Wei Keith Tan, Ross A Dierkhising, Julia E Crook, Michael G Heckman, Michele L Johnson, Ramona Lansing, Krish Ragunath, Massimiliano di Pietro, Herbert Wolfsen, Francisco Ramirez, David Fleischer, Kenneth K Wang, Cadman L Leggett, David A Katzka, Prasad G Iyer
Aug 14, 2020
OBJECTIVE: Surveillance interval protocols after complete remission of intestinal metaplasia (CRIM) post radiofrequency ablation (RFA) in Barrett's oesophagus (BE) are currently empiric and not based on substantial evidence. We...
Barrett’s oesophagus ENDOSCOPIC PROCEDURES OESOPHAGEAL CANCER Adenocarcinoma Aged Barrett Esophagus Biopsy Catheter Ablation Cohort Studies Disease Progression Esophageal Neoplasms Esophagogastric Junction Esophagoscopy esophagus Female Humans Male Metaplasia Middle Aged Neoplasm Recurrence Local Precancerous Conditions Risk Assessment United Kingdom United States
Ordering of mutations in preinvasive disease stages of esophageal carcinogenesis.
Jamie MJ Weaver, Caryn S Ross-Innes, Nicholas Shannon, Andy G Lynch, Tim Forshew, Mariagnese Barbera, Muhammed Murtaza, Chin-Ann J Ong, Pierre Lao-Sirieix, Mark J Dunning, Laura Smith, Mike L Smith, Charlotte L Anderson, Benilton Carvalho, Maria O'Donovan, Timothy J Underwood, Andrew P May, Nicola Grehan, Richard Hardwick, Jim Davies, Arusha Oloumi, Sam Aparicio, Carlos Caldas, Matthew D Eldridge, Paul AW Edwards, Nitzan Rosenfeld, Simon Tavaré, Rebecca C Fitzgerald, OCCAMS consortium
Feb 13, 2020
Cancer genome sequencing studies have identified numerous driver genes, but the relative timing of mutations in carcinogenesis remains unclear. The gradual progression from premalignant Barrett's esophagus to esophageal...
Early detection of pre-malignant lesions in a KRASG12D-driven mouse lung cancer model by monitoring circulating free DNA.
Callum P Rakhit, Ricky M Trigg, John Le Quesne, Michael Kelly, Jacqueline A Shaw, Catrin Pritchard, L Miguel Martins
Feb 07, 2019
Circulating free DNA Early detection KRASG12D Lung adenocarcinoma mouse model cfDNA Alleles Animals Cell-Free Nucleic Acids Disease Models Animal Early Detection of Cancer Female Integrases Lung Neoplasms Male Mice Inbred C57BL Mutation Precancerous Conditions Proto-Oncogene Proteins p21(ras) Recombination Genetic Reproducibility of Results Tumor Burden X-Ray Microtomography
Identification of novel prognostic markers in cervical intraepithelial neoplasia using LDMAS (LOH Data Management and Analysis Software).
Algorithms Alleles Biomarkers Tumor Computational Biology DNA Probes HPV DNA Neoplasm DNA Viral Data Interpretation Statistical Databases Genetic Female Hospital Information Systems Humans Loss of Heterozygosity Microsatellite Repeats Models Genetic Oligonucleotide Array Sequence Analysis Papillomaviridae Papillomavirus Infections Precancerous Conditions Prognosis Software Uterine Cervical Neoplasms Uterine Cervical Dysplasia
The Discovery and Validation of Biomarkers for the Diagnosis of Esophageal Squamous Dysplasia and Squamous Cell Carcinoma.
George Couch, James E Redman, Lorenz Wernisch, Richard Newton, Shalini Malhotra, Sanford M Dawsey, Pierre Lao-Sirieix, Rebecca C Fitzgerald
Apr 26, 2016
The utility of P53 immunohistochemistry in the diagnosis of Barrett's oesophagus with indefinite for dysplasia.
Wladyslaw Januszewicz, Nastazja D Pilonis, Tarek Sawas, Richard Phillips, Maria O'Donovan, Ahmad Miremadi, Shalini Malhotra, Monika Tripathi, Adrienn Blasko, David A Katzka, Rebecca C Fitzgerald, Massimiliano di Pietro
May 20, 2022
Autofluorescence-Directed Confocal Endomicroscopy in Combination With a Three-Biomarker Panel Can Inform Management Decisions in Barrett's Esophagus.
Massimiliano di Pietro, Elizabeth L Bird-Lieberman, Xinxue Liu, Tara Nuckcheddy-Grant, Helga Bertani, Maria O'Donovan, Rebecca C Fitzgerald
Nov 16, 2015
Aged Algorithms Aneuploidy Barrett Esophagus Biomarkers Biopsy Cyclin A Disease Progression Esophagoscopy esophagus False Positive Reactions Female Humans Male Microscopy Confocal Middle Aged Narrow Band Imaging Optical Imaging Precancerous Conditions Sensitivity and Specificity Tumor Suppressor Protein p53 Watchful Waiting
Genetic progression of Barrett's oesophagus to oesophageal adenocarcinoma.
Barrett's oesophagus (BE) is the premalignant condition associated with the development of oesophageal adenocarcinoma (OAC). Diagnostically, p53 immunohistochemistry remains the only biomarker recommended clinically to aid...
Adenocarcinoma Aneuploidy Barrett Esophagus Chromothripsis DNA Copy Number Variations DNA-Binding Proteins Disease Progression Esophageal Neoplasms Genomic Instability Humans Membrane Proteins Mutation Myosins Nerve Tissue Proteins Nuclear Proteins Precancerous Conditions Semaphorins Smad4 Protein Transcription Factors Tumor Suppressor Protein p53 Tumor Suppressor Proteins
Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis
Shinya Hayami, Masanori Yoshimatsu, Abhimanyu Veerakumarasivam, Motoko Unoki, Yukiko Iwai, Tatsuhiko Tsunoda, Helen I Field, John D Kelly, David E Neal, Hiroki Yamaue, Bruce AJ Ponder, Yusuke Nakamura, Ryuji Hamamoto
Sep 12, 2011
Cell Line Tumor Cell Proliferation E2F1 Transcription Factor E2F2 Transcription Factor Female Gene Expression Regulation Neoplastic Humans Jumonji Domain-Containing Histone Demethylases Male Nuclear Proteins Oligonucleotide Array Sequence Analysis Precancerous Conditions Repressor Proteins Reproducibility of Results Retinoblastoma Protein Signal Transduction Tissue Array Analysis Up-Regulation
Cytokine/chemokine profiles in squamous cell carcinoma correlate with precancerous and cancerous disease stage.
Zewen K Tuong, Andrew Lewandowski, Jennifer A Bridge, Jazmina LG Cruz, Miko Yamada, Duncan Lambie, Richard Lewandowski, Raymond J Steptoe, Graham R Leggatt, Fiona Simpson, Ian H Frazer, H Peter Soyer, James W Wells
Feb 03, 2020
Actinic Keratosis (AK), Intraepidermal Carcinoma (IEC), and Squamous Cell Carcinoma (SCC) are generally considered to be advancing stages of the same disease spectrum. However, while AK often regress spontaneously, and IEC often...