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Results: 220
Individual prognosis at diagnosis in nonmetastatic prostate cancer
David R Thurtle, David C Greenberg, Lui S Lee, Hong H Huang, Paul D Pharoah, Vincent J Gnanapragasam
Feb 18, 2019
Baroreflex sensitivity and heart rate variability are predictors of mortality in patients with aneurysmal subarachnoid haemorrhage.
Agnieszka Uryga, Małgorzata Burzyńska, Paweł Tabakow, Magdalena Kasprowicz, Karol P Budohoski, Agnieszka Kazimierska, Peter Smielewski, Marek Czosnyka, Waldemar Goździk
Feb 21, 2019
OBJECT: We aimed to investigate the link between the autonomic nervous system (ANS) impairment, assessed using baroreflex sensitivity (BRS) and heart rate variability (HRV) indices, and mortality after aneurysmal subarachnoid...
Baroreflex sensitivity heart rate variability Mortality Predictive modelling subarachnoid haemorrhage Adult Aged baroreflex Electrocardiography Female Glasgow Outcome Scale Heart Rate Homeostasis Humans Intensive Care Units Male Middle Aged Predictive Value of Tests Retrospective Studies statistics Nonparametric Subarachnoid Hemorrhage Ultrasonography Doppler Transcranial
Hemodynamic Instability and Cardiovascular Events After Traumatic Brain Injury Predict Outcome After Artifact Removal With Deep Belief Network Analysis.
BACKGROUND: Hemodynamic instability and cardiovascular events heavily affect the prognosis of traumatic brain injury. Physiological signals are monitored to detect these events. However, the signals are often riddled with faulty...
Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults
Michael Inouye, Gad Abraham, Christopher P Nelson, Angela M Wood, Michael J Sweeting, Frank Dudbridge, Florence Y Lai, Stephen Kaptoge, Marta Brozynska, Tingting Wang, Shu Ye, Thomas R Webb, Martin K Rutter, Ioanna Tzoulaki, Riyaz S Patel, Ruth JF Loos, Bernard Keavney, Harry Hemingway, John Thompson, Hugh Watkins, Panos Deloukas, Emanuele Di Angelantonio, Adam S Butterworth, John Danesh, Nilesh J Samani, UK Biobank CardioMetabolic Consortium CHD working group
Nov 22, 2018
BACKGROUND: Coronary artery disease (CAD) has substantial heritability and a polygenic architecture. However, the potential of genomic risk scores to help predict CAD outcomes has not been evaluated comprehensively, because...
Coronary Artery Disease genomic risk prediction Primary Prevention Coronary Artery Disease Female Genome-Wide Association Study Genomics Humans Male Mass Screening Middle Aged Multifactorial Inheritance Predictive Value of Tests Primary Prevention Research Design Risk Assessment Risk Factors United Kingdom
An exploratory study to clarify the cluster of symptoms predictive of chemotherapy-related nausea using random forest modeling.
CONTEXT: Chemotherapy-related nausea is experienced by most cancer patients receiving chemotherapy. Although vomiting is managed well with current antiemetics, nausea is difficult to manage and little is understood about its...
Universal screening for foetal growth restriction.
Gordon CS Smith
Jun 01, 2018
Foetal growth restriction (FGR) is a major cause of morbidity and mortality. Clinical methods for identifying women whose pregnancies are affected by FGR do not perform well. Despite this, the current approach to screening...
biomarker Doppler Foetal growth restriction Placenta screening ULTRASOUND Biomarkers Biometry Female Fetal Growth Retardation Gestational Age Humans Infant Newborn Mass Screening Placenta Predictive Value of Tests Pregnancy Prenatal Care Randomized Controlled Trials as Topic Research Design Risk Factors Ultrasonography Prenatal
On Modelling Minimal Disease Activity.
OBJECTIVE: To explore methods for statistical modelling of minimal disease activity (MDA) based on data from intermittent clinic visits. METHODS: The analysis was based on a 2-state model. Comparisons were made between analyses...
Perceptual integration for qualitatively different 3-D cues in the human brain.
The visual system's flexibility in estimating depth is remarkable: We readily perceive 3-D structure under diverse conditions from the seemingly random dots of a "magic eye" stereogram to the aesthetically beautiful, but...
DNA Methylation and Transcription Patterns in Intestinal Epithelial Cells From Pediatric Patients With Inflammatory Bowel Diseases Differentiate Disease Subtypes and Associate With Outcome.
Kate Joanne Howell, Judith Kraiczy, Komal M Nayak, Marco Gasparetto, Alexander Ross, Claire Lee, Tim N Mak, Bon-Kyoung Koo, Nitin Kumar, Trevor Lawley, Anupam Sinha, Philip Rosenstiel, Robert Heuschkel, Oliver Stegle, Matthias Zilbauer
Jan 24, 2018
BACKGROUND & AIMS: We analyzed DNA methylation patterns and transcriptomes of primary intestinal epithelial cells (IEC) of children newly diagnosed with inflammatory bowel diseases (IBD) to learn more about pathogenesis....
epigenetics Gut microbiota Human Intestinal Organoids Intestinal Epithelium Adolescent Age Factors Biopsy Case-Control Studies Colitis Ulcerative Colon Sigmoid Crohn Disease DNA Methylation Diagnosis Differential England Epigenesis Genetic Epithelial Cells Female Gastrointestinal Microbiome Gene Expression Profiling Genome-Wide Association Study Humans Ileum Intestinal Mucosa Male Organoids Predictive Value of Tests Prognosis Prospective Studies Ribotyping Time Factors Tissue Culture Techniques Transcription Genetic Transcriptome
Estimated stroke risk, yield, and number needed to screen for atrial fibrillation detected through single time screening
Nicole Lowres, Jake Olivier, Tze-Fan Chao, Shih-Ann Chen, Yi Chen, Axel Diederichsen, David A Fitzmaurice, Juan Jose Gomez-Doblas, Joseph Harbison, Jeff S Healey, FD Richard Hobbs, Femke Kaasenbrood, William Keen, Vivian W Lee, Jes S Lindholt, Gregory YH Lip, Georges H Mairesse, Jonathan Mant, Julie W Martin, Enrique Martín-Rioboó, David D McManus, Javier Muñiz, Thomas Münzel, Juliet Nakamya, Lis Neubeck, Jessica J Orchard, Luis Ángel Pérula de Torres, Marco Proietti, F Russell Quinn, Andrea K Roalfe, Roopinder K Sandhu, Renate B Schnabel, Breda Smyth, Apurv Soni, Robert Tieleman, Jiguang Wang, Philipp S Wild, Bryan P Yan, Ben Freedman
Sep 04, 2019
Evaluation of FTIR spectroscopy as a diagnostic tool for lung cancer using sputum.
Paul D Lewis, Keir E Lewis, Robin Ghosal, Sion Bayliss, Amanda J Lloyd, John Wills, Ruth Godfrey, Philip Kloer, Luis AJ Mur
May 13, 2020
BACKGROUND: Survival time for lung cancer is poor with over 90% of patients dying within five years of diagnosis primarily due to detection at late stage. The main objective of this study was to evaluate Fourier transform...
Study protocol. A prospective cohort study of unselected primiparous women
Dharmintra Pasupathy, Alison Dacey, Emma Cook, D Stephen Charnock-Jones, Ian R White, Gordon CS Smith
Jun 16, 2011
BACKGROUND: There have been dramatic changes in the approach to screening for aneuploidy over the last 20 years. However, the approach to screening for other complications of pregnancy such as intra-uterine growth restriction...
An unusual finding in a 57-year-old woman with new onset hypertension and a diastolic murmur.
CLINICAL INTRODUCTION: A 57-year-old woman presented to our clinic with breathlessness brought on while walking uphill. She had been recently diagnosed with systemic hypertension. There was no known family history of cardiac...
Computed Tomography Angiography Coronary Aneurysm Coronary Angiography Echocardiography Female Fluorodeoxyglucose F18 Heart Murmurs Hemodynamics Humans Hypertension Magnetic Resonance Imaging Middle Aged Multimodal Imaging Positron-Emission Tomography Predictive Value of Tests Radiopharmaceuticals Takayasu arteritis
High Structural Stress and Presence of Intraluminal Thrombus Predict Abdominal Aortic Aneurysm 18F-FDG Uptake
Yuan Huang, Zhongzhao Teng, Maysoon Elkhawad, Jason M Tarkin, Nikhil Joshi, Jonathan R Boyle, John R Buscombe, Timothy D Fryer, Yongxue Zhang, Ah Yeon Park, Ian B Wilkinson, David E Newby, Jonathan H Gillard, James HF Rudd
Nov 10, 2016
abdominal aortic aneurysm Fluorodeoxyglucose F18 Inflammation mechanical stress Positron-Emission Tomography Thrombosis Aged Aged 80 and over Aorta Abdominal Aortic Aneurysm Abdominal Aortic Rupture Aortitis Aortography Biomechanical Phenomena Computed Tomography Angiography Female Finite element analysis Fluorodeoxyglucose F18 Humans Linear Models Male Middle Aged Multivariate Analysis Positron Emission Tomography Computed Tomography Predictive Value of Tests Prognosis Pulsatile Flow Radiographic Image Interpretation Computer-Assisted Radiopharmaceuticals Regional Blood Flow Risk Factors Stress Mechanical Thrombosis Vascular Calcification
Thresholds for Arterial Wall Inflammation Quantified by 18F-FDG PET Imaging
Fleur M van der Valk, Simone L Verweij, Koos AH Zwinderman, Aart C Strang, Yannick Kaiser, Henk A Marquering, Aart J Nederveen, Erik SG Stroes, Hein J Verberne, James HF Rudd
May 05, 2016
(18)F-FDG PET/CT Atherosclerosis Imaging Inflammation thresholds Aged Aorta Aortitis Arteritis Carotid Arteries Carotid Artery Diseases Case-Control Studies Female Fluorodeoxyglucose F18 Humans Male Middle Aged Observer Variation Plaque Atherosclerotic Positron-Emission Tomography Predictive Value of Tests Radiopharmaceuticals Reproducibility of Results
Plaque Structural Stress Estimations Improve Prediction of Future Major Adverse Cardiovascular Events After Intracoronary Imaging.
Adam J Brown, Zhongzhao Teng, Patrick A Calvert, Nikil K Rajani, Orla Hennessy, Nitesh Nerlekar, Daniel R Obaid, Charis Costopoulos, Yuan Huang, Stephen P Hoole, Martin Goddard, Nick EJ West, Jonathan H Gillard, Martin R Bennett
Jun 09, 2016
Atherosclerosis Autopsy Coronary Disease Myocardial Infarction Prospective Studies Acute Coronary Syndrome Aged Angina Stable Coronary Artery Disease Coronary Vessels Disease-Free Survival Female Fibrosis Humans Kaplan-Meier Estimate Male Middle Aged Necrosis Percutaneous Coronary Intervention Plaque Atherosclerotic Predictive Value of Tests Proportional Hazards Models Prospective Studies Risk Factors Rupture Spontaneous Severity of Illness Index Stress Mechanical Time Factors Treatment Outcome Ultrasonography Interventional Vascular Calcification
Highlights of the fourteenth annual scientific meeting of the Society of Cardiovascular Computed Tomography.
Jonathan R Weir-McCall, Edward Nicol, Suhny Abbara, Kelley Branch, Andrew D Choi, Brian B Ghoshhajra, Jonathon Leipsic, Koen Nieman, Leslee J Shaw, Ron Blankstein
Sep 28, 2020
The 14th Annual Scientific Meeting of the SCCT, held from July 11 to July 14 in Baltimore, MA, was attended by 830 attendees from 31 countries, with a program that included 45 sessions, and 26 exhibitors. This article summarizes...
Baseline Interleukin-6 and -8 predict response and survival in patients with advanced hepatocellular carcinoma treated with sorafenib monotherapy
Osman Öcal, Kerstin Schütte, Juozas Kupčinskas, Egidijus Morkunas, Gabija Jurkeviciute, Enrico N de Toni, Najib Ben Khaled, Thomas Berg, Peter Malfertheiner, Heinz Josef Klümpen, Christian Sengel, Bristi Basu, Juan W Valle, Julia Benckert, Antonio Gasbarrini, Daniel Palmer, Ricarda Seidensticker, Moritz Wildgruber, Bruno Sangro, Maciej Pech, Jens Ricke, Max Seidensticker
Jan 30, 2022
hepatocellular carcinoma interleukin response Sorafenib Adolescent Adult Aged Aged 80 and over Carcinoma Hepatocellular Disease Progression Europe Female Follow-Up Studies Humans Interleukin-6 Interleukin-8 Liver Neoplasms Male Middle Aged Predictive Value of Tests Prognosis Sorafenib Survival Analysis Turkey Young Adult
Sex-Specific Computed Tomography Coronary Plaque Characterization and Risk of Myocardial Infarction.
Michelle C Williams, Jacek Kwiecinski, Mhairi Doris, Priscilla McElhinney, Michelle S D'Souza, Sebastien Cadet, Philip D Adamson, Alastair J Moss, Shirjel Alam, Amanda Hunter, Anoop SV Shah, Nicholas L Mills, Tania Pawade, Chengjia Wang, Jonathan R Weir-McCall, Michael Bonnici-Mallia, Christopher Murrills, Giles Roditi, Edwin JR van Beek, Leslee J Shaw, Edward D Nicol, Daniel S Berman, Piotr J Slomka, David E Newby, Marc R Dweck, Damini Dey
Apr 23, 2021
OBJECTIVES: This study was designed to investigate whether coronary computed tomography angiography assessments of coronary plaque might explain differences in the prognosis of men and women presenting with chest pain....
Computed tomography computed tomography coronary angiography Coronary Artery Disease quantitative plaque analysis sex Computed Tomography Angiography Coronary Angiography Coronary Artery Disease Coronary Vessels Female Humans Male Myocardial Infarction Plaque Atherosclerotic Predictive Value of Tests Risk Factors
Which Neuropsychological Tests? Predicting Cognitive Decline and Dementia in Parkinson's Disease in the ICICLE-PD Cohort.
Rachael A Lawson, Caroline H Williams-Gray, Marta Camacho, Gordon W Duncan, Tien K Khoo, David P Breen, Roger A Barker, Lynn Rochester, David J Burn, Alison J Yarnall, ICICLE-PD study group
May 28, 2021
BACKGROUND: Cognitive impairment is common in Parkinson's disease (PD), with 80% cumulatively developing dementia (PDD). OBJECTIVE: We sought to identify tests that are sensitive to change over time above normal ageing so as to...
Elevated Baseline C-Reactive Protein as a Predictor of Outcome After Aneurysmal Subarachnoid Hemorrhage
Carole L Turner, Karol Budohoski, Christopher Smith, Peter J Hutchinson, Peter J Kirkpatrick, GD Murray, STASH collaborators
Jul 14, 2015
Imaging Atherosclerosis.
Jason M Tarkin, Marc R Dweck, Nicholas R Evans, Richard AP Takx, Adam J Brown, Ahmed Tawakol, Zahi A Fayad, James HF Rudd
Dec 23, 2015
Atherosclerosis Coronary Artery Disease Molecular Imaging Multimodal Imaging Risk Factors Coronary Angiography Coronary Artery Disease Coronary Vessels Diagnostic Imaging Humans Magnetic Resonance Angiography Multimodal Imaging Plaque Atherosclerotic Positron-Emission Tomography Predictive Value of Tests Prognosis Risk Assessment Risk Factors Severity of Illness Index Tomography Emission-Computed Single-Photon Tomography Optical Coherence Tomography X-Ray Computed Ultrasonography Interventional
Adiposity and grip strength as long-term predictors of objectively measured physical activity in 93 015 adults
Identification of pathologically insignificant prostate cancer is not accurate in unscreened men.
GL Shaw, BC Thomas, SN Dawson, G Srivastava, SL Vowler, VJ Gnanapragasam, NC Shah, AY Warren, DE Neal
Jun 11, 2018
BACKGROUND: Identification of men harbouring insignificant prostate cancer (PC) is important in selecting patients for active surveillance. Tools have been developed in PSA-screened populations to identify such men based on...
Adenocarcinoma Aged Area Under Curve Biopsy Needle Early Detection of Cancer False Negative Reactions Humans Lymphatic Metastasis Magnetic Resonance Imaging Male Middle Aged Neoplasm Grading Neoplasm Staging Organ Size Patient Selection Predictive Value of Tests Prostate Prostate-specific antigen Prostatic Neoplasms ROC Curve Retrospective Studies Risk Assessment Seminal vesicles Sensitivity and Specificity Tumor Burden Watchful Waiting
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