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Results: 40
Integrin α2 marks a niche of trophoblast progenitor cells in first trimester human placenta.
Cheryl QE Lee, Margherita Y Turco, Lucy Gardner, Benjamin D Simons, Myriam Hemberger, Ashley Moffett
Mar 09, 2018
During pregnancy the trophoblast cells of the placenta are the only fetal cells in direct contact with maternal blood and decidua. Their functions include transport of nutrients and oxygen, secretion of pregnancy hormones...
Associations between paternally transmitted fetal IGF2 variants and maternal circulating glucose concentrations in pregnancy.
Clive J Petry, Rachel V Seear, Dianne L Wingate, Lucy Manico, Carlo L Acerini, Ken K Ong, Ieuan A Hughes, David B Dunger
Feb 21, 2020
OBJECTIVE: To test the hypothesis that polymorphic variation in the paternally transmitted fetal IGF2 gene is associated with maternal glucose concentrations in the third trimester of pregnancy. RESEARCH DESIGN AND METHODS: A...
Adult Alleles Blood Glucose Cohort Studies Female Genetic Association Studies Glucose Humans Hyperglycemia Infant Newborn Insulin-Like Growth Factor II Male Placenta Polymorphism Single Nucleotide Pregnancy Pregnancy Complications Pregnancy Proteins Pregnancy Trimester Third Prospective Studies Retrospective Studies Sexual Partners United Kingdom
Investigation of human trophoblast invasion in vitro.
Cheryl QE Lee, Lucy Gardner, Margherita Turco, Nancy Zhao, Matthew J Murray, Nicholas Coleman, Janet Rossant, Myriam Hemberger, Ashley Moffett
Jan 14, 2016
Biomarkers Cells Cultured Chromosomes Human Pair 19 DNA Methylation DNA-Binding Proteins Female Fibroblast Growth Factors Histocompatibility Antigens Class I Human Embryonic Stem Cells Humans MicroRNAs Pregnancy Pregnancy Trimester First Promoter Regions Genetic Proto-Oncogene Proteins c-ets Pyrimidines Terminology as Topic Transcription Factors Trophoblasts
Should we implement universal screening with late pregnancy ultrasound to prevent stillbirth?
Gcs Smith
Nov 24, 2017
NIHR Cambridge Comprehensive Biomedical Research Centre
Early first trimester uteroplacental flow and the progressive disintegration of spiral artery plugs
STUDY QUESTION: Does the use of a vascular contrast agent facilitate earlier detection of maternal flow to the placental intervillous space (IVS) in the first trimester of pregnancy? SUMMARY ANSWER: Microvascular filling of the...
Phenotypic and functional characterization of first-trimester human placental macrophages, Hofbauer cells.
Jake R Thomas, Anna Appios, Xiaohui Zhao, Roksana Dutkiewicz, Maria Donde, Colin YC Lee, Praveena Naidu, Christopher Lee, Joana Cerveira, Bing Liu, Florent Ginhoux, Graham Burton, Russell S Hamilton, Ashley Moffett, Andrew Sharkey, Naomi McGovern
Oct 27, 2020
Accelerated Fetal Growth Prior to Diagnosis of Gestational Diabetes Mellitus
Uterine artery pulsatility and resistivity indices in pregnancy
RA Hawkes, AJ Patterson, AN Priest, G Harrison, S Hunter, J Pinney, P Set, N Hilliard, MJ Graves, Gcs Smith, DJ Lomas
Apr 27, 2016
The cost-effectiveness of universal late-pregnancy screening for macrosomia in nulliparous women
D Wastlund, AA Moraitis, JG Thornton, J Sanders, IR White, P Brocklehurst, Gcs Smith, ECF Wilson
May 03, 2019
economic modelling health economics Macrosomia Pregnancy screening third-trimester ULTRASOUND Adult Cost-Benefit Analysis Decision Support Techniques England Female Fetal Macrosomia Health Services Research Humans Parity Patient Selection Pregnancy Pregnancy Trimester Third Prenatal Care Ultrasonography Prenatal
An Unbiased Lipidomics Approach Identifies Early Second Trimester Lipids Predictive of Maternal Glycemic Traits and Gestational Diabetes Mellitus.
Liangjian Lu, Albert Koulman, Clive J Petry, Benjamin Jenkins, Lee Matthews, Ieuan A Hughes, Carlo L Acerini, Ken K Ong, David B Dunger
Nov 03, 2016
Tissue stiffness at the human maternal-fetal interface.
Yassen Abbas, Alejandro Carnicer-Lombarte, Lucy Gardner, Jake Thomas, Jan J Brosens, Ashley Moffett, Andrew M Sharkey, Kristian Franze, Graham J Burton, Michelle L Oyen
Oct 14, 2019
blastocyst implantation human Mechanics tissue stiffness trophoblast invasion Blastocyst Cell Movement Collagen Decidua Drug Combinations Elastic Modulus Elasticity Imaging Techniques Embryo Implantation Endometrium Extracellular Matrix Female Humans Laminin Microscopy Atomic Force Placenta Placentation Pregnancy Pregnancy Trimester First Proteoglycans
Routine Third Trimester Sonogram
Several risk factors for adverse pregnancy outcomes can be identified by a routine third trimester ultrasound scan. However, there is also potential for harm, anxiety, and additional health care costs through unnecessary...
Doppler fetal growth restriction Fetal presentation large for gestational age screening Small for gestational age Stillbirth ULTRASOUND Amniotic Fluid Anxiety Biomarkers Breech Presentation False Positive Reactions Female Fetal Development Fetal Growth Retardation Fetal Macrosomia Humans Pregnancy Pregnancy Outcome Pregnancy Trimester Third Prenatal Diagnosis Risk Factors Stillbirth Ultrasonography Doppler Ultrasonography Prenatal
Prenatal attachment
Sarah Foley, Claire Hughes, Aja Louise Murray, Adriana Baban, Asvini D Fernando, Bernadette Madrid, Joseph Osafo, Siham Sikander, Fahad Abbasi, Susan Walker, Bao-Yen Luong-Thanh, Thang Van Vo, Mark Tomlinson, Pasco Fearon, Catherine L Ward, Sara Valdebenito, Manuel Eisner
Feb 01, 2021
Maternal infections during pregnancy and child cognitive outcomes.
Janell Kwok, Hildigunnur Anna Hall, Aja Louise Murray, Michael Vincent Lombardo, Bonnie Auyeung
Dec 18, 2022
BACKGROUND: Maternal prenatal infections have been linked to children's neurodevelopment and cognitive outcomes. It remains unclear, however, whether infections occurring during specific vulnerable gestational periods can affect...
Lower accuracy in prediction of delivery date in Stockholm County following introduction of new guidelines.
INTRODUCTION: In Stockholm County, new guidelines for predicting the day of delivery were introduced in 2010. Recent clinical use has indicated that the predictive quality might be suboptimal. This study compares the accuracy of...
Gestational Age bi-parietal diameter Crown-Rump Length Estimated date of delivery femur length fetal biometry postterm pregnancy quality assessment Adult Algorithms Biometry Cephalometry Crown-Rump Length delivery Obstetric Female Femur Gestational Age Humans Practice Guidelines as Topic Pregnancy Pregnancy Trimester First Pregnancy Trimester Second Ultrasonography Prenatal
Fetal exome sequencing for isolated increased nuchal translucency
R Mellis, RY Eberhardt, SJ Hamilton, PAGE Consortium, DJ McMullan, MD Kilby, ER Maher, ME Hurles, JL Giordano, V Aggarwal, DB Goldstein, RJ Wapner, LS Chitty
Sep 14, 2021
Fetal diagnosis and therapy Genetics Perinatal diagnosis-invasive Perinatal diagnosis-ultrasound Adult Cohort Studies Female Humans Nuchal Translucency Measurement Predictive Value of Tests Pregnancy Pregnancy Trimester First Prenatal Diagnosis Prospective Studies Retrospective Studies Trisomy Ultrasonography Prenatal United Kingdom United States Exome Sequencing
Preconception and early pregnancy maternal haemodynamic changes in healthy women in relation to pregnancy viability.
STUDY QUESTION: Are there differences in preconception cardiovascular function between women who have a viable pregnancy and those who have a first trimester miscarriage? SUMMARY ANSWER: Preconception cardiovascular function of...
Change in maternal cardiac output from preconception to mid-pregnancy is associated with birth weight in healthy pregnancies.
OBJECTIVE: Birth weight (BW) is thought to be determined by maternal health and genetic, nutritional and placental factors, the latter being influenced by anatomical development and perfusion. Maternal cardiovascular changes...
Fetal umbilical artery Doppler as a tool for universal third trimester screening
Alexandros A Moraitis, Thomas Bainton, Ulla Sovio, Peter Brocklehurst, Alexander EP Heazell, Jim G Thornton, Stephen C Robson, Aris Papageorghiou, Gordon CS Smith
Mar 24, 2021
The objective of this study was to investigate the accuracy of universal third trimester umbilical artery (UA) Doppler to predict adverse pregnancy outcome at term. We searched Medline, EMBASE, the Cochrane library and...
RNA-Seq reveals changes in human placental metabolism, transport and endocrinology across the first-second trimester transition.
Malwina Prater, Russell S Hamilton, Hong Wa Yung, Andrew M Sharkey, Paul Robson, N Erlyani Abd Hamid, Eric Jauniaux, D Stephen Charnock-Jones, Graham J Burton, Tereza Cindrova-Davies
Apr 14, 2021
Early placenta Human pregnancy metabolism Methylation Transcriptome Biomarkers Computational Biology Energy Metabolism Female Gene Expression Profiling Gene Expression Regulation Gene Ontology Humans Immunohistochemistry Molecular Sequence Annotation Placenta Pregnancy Pregnancy Trimester First Pregnancy Trimester Second RNA-seq
Circulating SPINT1 is a biomarker of pregnancies with poor placental function and fetal growth restriction.
Tu'uhevaha J Kaitu'u-Lino, Teresa M MacDonald, Ping Cannon, Tuong-Vi Nguyen, Richard J Hiscock, Nick Haan, Jenny E Myers, Roxanne Hastie, Kirsten M Dane, Anna L Middleton, Intissar Bittar, Amanda N Sferruzzi-Perri, Natasha Pritchard, Alesia Harper, Natalie J Hannan, Valerie Kyritsis, Nick Crinis, Lisa Hui, Susan P Walker, Stephen Tong
Jul 17, 2020
Placental insufficiency can cause fetal growth restriction and stillbirth. There are no reliable screening tests for placental insufficiency, especially near-term gestation when the risk of stillbirth rises. Here we show a...
Animals Anthropometry Biomarkers Female Fetal Growth Retardation Humans Infant Newborn Infant Small for Gestational Age Mice Placenta Placental Insufficiency Plethysmography Predictive Value of Tests Pregnancy Pregnancy Trimester Third Proteinase Inhibitory Proteins Secretory Sensitivity and Specificity Ultrasonography Prenatal Umbilical Arteries Uterine Artery
Expression of SARS-CoV-2 receptor ACE2 and the protease TMPRSS2 suggests susceptibility of the human embryo in the first trimester.
While initially recognized as causing respiratory disease, the SARS-CoV-2 virus also affects many other organs leading to other complications. It has emerged that advanced age and obesity are risk factors for complications but...
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