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Placenta accreta spectrum
Placenta accreta spectrum is a complex obstetric complication associated with high maternal morbidity. It is a relatively new disorder of placentation, and is the consequence of damage to the endometrium-myometrial interface of...
MR-based morphometry of the posterior fossa in fetuses with neural tube defects of the spine.
Ramona Woitek, Anton Dvorak, Michael Weber, Rainer Seidl, Dieter Bettelheim, Veronika Schöpf, Gabriele Amann, Peter C Brugger, Julia Furtner, Ulrika Asenbaum, Daniela Prayer, Gregor Kasprian
Jan 02, 2019
OBJECTIVES: In cases of "spina bifida," a detailed prenatal imaging assessment of the exact morphology of neural tube defects (NTD) is often limited. Due to the diverse clinical prognosis and prenatal treatment options, imaging...
Fetal hydrops and the Incremental yield of Next-generation sequencing over standard prenatal Diagnostic testing (FIND) study
F Mone, RY Eberhardt, ME Hurles, DJ McMullan, ER Maher, J Lord, LS Chitty, E Dempsey, T Homfray, JL Giordano, RJ Wapner, L Sun, TN Sparks, ME Norton, MD Kilby
Oct 01, 2021
OBJECTIVE: To determine the incremental yield of exome sequencing (ES) over chromosomal microarray analysis (CMA) or karyotyping in prenatally diagnosed non-immune hydrops fetalis (NIHF). METHODS: A prospective cohort study...
Severe mood disorders and schizophrenia in the adult offspring of antenatally depressed mothers in the Northern Finland 1966 Birth Cohort
BACKGROUND: Maternal antenatal depression may alter offspring neurodevelopment, but long follow-up studies are lacking. We studied the risks for mood disorders and schizophrenia in adult offspring of antenatally depressed...
Antenatal Bipolar Disorder Depression Mood Disorders Parental mental disorder Schizophrenia Adolescent Adult Adult Children Child Child of Impaired Parents Cohort Studies Depressive Disorder Female Finland Follow-Up Studies Humans Mood Disorders Mother-Child Relations Mothers Pregnancy Pregnancy Complications Prenatal Diagnosis Schizophrenic Psychology Young Adult
Routine Third Trimester Sonogram
Several risk factors for adverse pregnancy outcomes can be identified by a routine third trimester ultrasound scan. However, there is also potential for harm, anxiety, and additional health care costs through unnecessary...
Doppler fetal growth restriction Fetal presentation large for gestational age screening Small for gestational age Stillbirth ULTRASOUND Amniotic Fluid Anxiety Biomarkers Breech Presentation False Positive Reactions Female Fetal Development Fetal Growth Retardation Fetal Macrosomia Humans Pregnancy Pregnancy Outcome Pregnancy Trimester Third Prenatal Diagnosis Risk Factors Stillbirth Ultrasonography Doppler Ultrasonography Prenatal
Fetal diffusion tensor quantification of brainstem pathology in Chiari II malformation.
Ramona Woitek, Daniela Prayer, Michael Weber, Gabriele Amann, Rainer Seidl, Dieter Bettelheim, Veronika Schöpf, Peter C Brugger, Julia Furtner, Ulrika Asenbaum, Gregor Kasprian
Aug 05, 2019
OBJECTIVES: This prenatal MRI study evaluated the potential of diffusion tensor imaging (DTI) metrics to identify changes in the midbrain of fetuses with Chiari II malformations compared to fetuses with mild ventriculomegaly...
Screening for fetal growth restriction using fetal biometry combined with maternal biomarkers.
Francesca Gaccioli, Irving LMH Aye, Ulla Sovio, D Stephen Charnock-Jones, Gordon CS Smith
Mar 29, 2018
Fetal growth restriction is a major determinant of perinatal morbidity and mortality. Screening for fetal growth restriction is a key element of prenatal care but it is recognized to be problematic. Screening using clinical risk...
A-disintegrin and metalloprotease 12 alpha fetoprotein biomarker fetal biometry Fetal Death human chorionic gonadotropin human placental lactogen inhibin Models Placenta placental growth factor placental protein 13 PREDICTION Pregnancy-Associated Plasma Protein-A Randomized controlled trial Review screening Small for gestational age soluble endoglin soluble fms-like tyrosine kinase-1 Stillbirth study design ULTRASOUND ADAM12 Protein Biomarkers Biometry Calcium-Binding Proteins Chorionic Gonadotropin Endoglin Estriol Female Fetal Growth Retardation Galectins Humans Inhibins Intercellular Signaling Peptides and Proteins Laser-Doppler Flowmetry Membrane Proteins Placenta Growth Factor Placental Circulation Placental Lactogen Pregnancy Pregnancy Proteins Pregnancy-Associated Plasma Protein-A Prenatal Diagnosis Ultrasonography Prenatal Vascular Endothelial Growth Factor Receptor-1 alpha-Fetoproteins
Fetal exome sequencing for isolated increased nuchal translucency
R Mellis, RY Eberhardt, SJ Hamilton, PAGE Consortium, DJ McMullan, MD Kilby, ER Maher, ME Hurles, JL Giordano, V Aggarwal, DB Goldstein, RJ Wapner, LS Chitty
Sep 14, 2021
Fetal diagnosis and therapy Genetics Perinatal diagnosis-invasive Perinatal diagnosis-ultrasound Adult Cohort Studies Female Humans Nuchal Translucency Measurement Predictive Value of Tests Pregnancy Pregnancy Trimester First Prenatal Diagnosis Prospective Studies Retrospective Studies Trisomy Ultrasonography Prenatal United Kingdom United States Exome Sequencing
Expert consensus document: Clinical and molecular diagnosis, screening and management of Beckwith-Wiedemann syndrome
Frédéric Brioude, Jennifer M Kalish, Alessandro Mussa, Alison C Foster, Jet Bliek, Giovanni Battista Ferrero, Susanne E Boonen, Trevor Cole, Robert Baker, Monica Bertoletti, Guido Cocchi, Carole Coze, Maurizio De Pellegrin, Khalid Hussain, Abdulla Ibrahim, Mark D Kilby, Malgorzata Krajewska-Walasek, Christian P Kratz, Edmund J Ladusans, Pablo Lapunzina, Yves Le Bouc, Saskia M Maas, Fiona MacDonald, Katrin Õunap, Licia Peruzzi, Sylvie Rossignol, Silvia Russo, Caroleen Shipster, Agata Skórka, Katrina Tatton-Brown, Jair Tenorio, Chiara Tortora, Karen Grønskov, Irène Netchine, Raoul C Hennekam, Dirk Prawitt, Zeynep Tümer, Thomas Eggermann, Deborah JG Mackay, Andrea Riccio, Eamonn R Maher
Jul 02, 2018
Beckwith-Wiedemann syndrome (BWS), a human genomic imprinting disorder, is characterized by phenotypic variability that might include overgrowth, macroglossia, abdominal wall defects, neonatal hypoglycaemia, lateralized...
Thomas Eggermann, Frédéric Brioude, Silvia Russo, Maria P Lombardi, Jet Bliek, Eamonn R Maher, Lidia Larizza, Dirk Prawitt, Irène Netchine, Marie Gonzales, Karen Grønskov, Zeynep Tümer, David Monk, Marcel Mannens, Krystyna Chrzanowska, Malgorzata K Walasek, Matthias Begemann, Lukas Soellner, Katja Eggermann, Jair Tenorio, Julián Nevado, Gudrun E Moore, Deborah JG Mackay, Karen Temple, Gabriele Gillessen-Kaesbach, Tsutomu Ogata, Rosanna Weksberg, Elizabeth Algar, Pablo Lapunzina
Oct 15, 2015
Evidence for Better Lives Study
Sara Valdebenito, AJA Murray, Claire Hughes, Adriana Băban, Asvini D Fernando, Bernadette J Madrid, Catherine Ward, Joseph Osafo, Michael Dunne, Siham Sikander, Susan P Walker, Vo Van Thang, Mark Tomlinson, Pasco Fearon, Yulia Shenderovich, Marguerite Marlow, Deshanie Chathurika, Diana Taut, Manuel Eisner
Sep 28, 2020
child protection community child health EPIDEMIOLOGY Mental Health Prenatal Diagnosis Child Cohort Studies Developing Countries Exposure to Violence Female Ghana Humans intimate partner violence Jamaica Longitudinal Studies Pakistan Philippines Pregnancy Romania South Africa sri lanka Vietnam violence
Fetal umbilical artery Doppler as a tool for universal third trimester screening
Alexandros A Moraitis, Thomas Bainton, Ulla Sovio, Peter Brocklehurst, Alexander EP Heazell, Jim G Thornton, Stephen C Robson, Aris Papageorghiou, Gordon CS Smith
Mar 24, 2021
The objective of this study was to investigate the accuracy of universal third trimester umbilical artery (UA) Doppler to predict adverse pregnancy outcome at term. We searched Medline, EMBASE, the Cochrane library and...
Amniotic fluid volume
NJ Hilliard, R Hawkes, AJ Patterson, MJ Graves, AN Priest, S Hunter, C Lees, PA Set, DJ Lomas
Dec 18, 2015
Screening and prevention of stillbirth.
Gordon CS Smith
Nov 02, 2016
Biomarkers intervention screening Stillbirth ULTRASOUND ABO Blood-Group System Abortion Spontaneous Black People Cesarean Section delivery Obstetric Diabetes mellitus Female Humans Infant Newborn Labor Induced Maternal Age obesity Parity Perinatal Death Pregnancy Pregnancy Complications Pregnancy Multiple Pregnancy-Associated Plasma Protein-A Prenatal Diagnosis Risk Assessment Risk Factors Stillbirth Substance-Related Disorders Tobacco Smoke Pollution Ultrasonography Prenatal alpha-Fetoproteins
Is self-management a burden? What are the experiences of women self-managing chronic conditions during pregnancy? A systematic review.
Bethany Ellen Jakubowski, Lisa Hinton, Jaspreet Khaira, Nia Roberts, Richard J McManus, Katherine Louise Tucker
Mar 28, 2022
COngenital heart disease and the Diagnostic yield with Exome sequencing (CODE) study
F Mone, RY Eberhardt, RK Morris, ME Hurles, DJ McMullan, ER Maher, J Lord, LS Chitty, JL Giordano, RJ Wapner, MD Kilby, CODE Study Collaborators
Sep 10, 2020
OBJECTIVE: To determine the incremental yield of antenatal exome sequencing (ES) over chromosomal microarray analysis (CMA) or conventional karyotyping in prenatally diagnosed congenital heart disease (CHD). METHODS: A...
Developing Novel Tests to Screen for Fetal Growth Restriction.
Gordon CS Smith
May 27, 2021
Fetal growth restriction (FGR) is a major determinant of global morbidity and mortality. There is an unmet need for methods to stratify the pregnant population on the basis of FGR risk. Despite evolutionary divergence in...
fetal growth restriction Genomics Metabolomics Placenta Proteomics Small for gestational age Animals Biomarkers Disease Management Disease Models Animal Disease Susceptibility Female Fetal Development Fetal Growth Retardation Genomics Humans Infant Low Birth Weight Infant Newborn Metabolomics Placenta Pregnancy Prenatal Diagnosis Proteomics
Diagnosis of lethal or prenatal-onset autosomal recessive disorders by parental exome sequencing.
Karen L Stals, Matthew Wakeling, Júlia Baptista, Richard Caswell, Andrew Parrish, Julia Rankin, Carolyn Tysoe, Garan Jones, Adam C Gunning, Hana Lango Allen, Lisa Bradley, Angela F Brady, Helena Carley, Jenny Carmichael, Bruce Castle, Deirdre Cilliers, Helen Cox, Charu Deshpande, Abhijit Dixit, Jacqueline Eason, Frances Elmslie, Andrew E Fry, Alan Fryer, Muriel Holder, Tessa Homfray, Emma Kivuva, Victoria McKay, Ruth Newbury-Ecob, Michael Parker, Ravi Savarirayan, Claire Searle, Nora Shannon, Deborah Shears, Sarah Smithson, Ellen Thomas, Peter D Turnpenny, Vinod Varghese, Pradeep Vasudevan, Emma Wakeling, Emma L Baple, Sian Ellard
Jan 03, 2020
Reliability and validity of last menstrual period for gestational age estimation in a low-to-middle-income setting.
Molecular autopsy by trio exome sequencing (ES) and postmortem examination in fetuses and neonates with prenatally identified structural anomalies.
Elizabeth Quinlan-Jones, Jenny Lord, Denise Williams, Sue Hamilton, Tamas Marton, Ruth Y Eberhardt, Gabriele Rinck, Elena Prigmore, Rebecca Keelagher, Dominic J McMullan, Eamonn R Maher, Matthew E Hurles, Mark D Kilby
Nov 19, 2018
Assessment of venous hemodynamics and volume homeostasis during pregnancy
Venous hemodynamics and volume homeostasis are important aspects of cardiovascular physiology. However, today their relevance is still very much underappreciated. Their most important role is maintenance and control of venous...
maternal hemodynamics plasma volume Pregnancy venous hemodynamics venous return volume homeostasis Blood Flow Velocity cardiac output Cardiovascular Physiological Phenomena Consensus Development Conferences as Topic Female Guidelines as Topic Hemodynamics Homeostasis Humans Maternal Health Pregnancy Pregnancy Complications Cardiovascular Prenatal Diagnosis Uterine Artery
Evidence for Better Lives Study
Sara Valdebenito, AJA Murray, Claire Hughes, Adriana Băban, Asvini D Fernando, Bernadette J. Madrid, Catherine Ward, Joseph Osafo, Michael Dunne, Siham Sikander, Susan P Walker, Vo Van Thang, Mark Tomlinson, Pasco Fearon, Yulia Shenderovich, Marguerite Marlow, Deshanie Chathurika, Diana Taut, Manuel Eisner
Oct 14, 2020
Integration of antenatal syphilis screening in an urban HIV clinic
Yukari C Manabe, Gertrude Namale, Elizabeth Nalintya, Joseph Sempa, Rosalind Parkes Ratanshi, Nadine Pakker, Elly Katabira
Jun 27, 2018
BACKGROUND: Syphilis infection during pregnancy leads to avoidable morbidity and mortality and remains a significant problem in sub-Saharan Africa. Despite global initiatives to increase the proportion of pregnant women...
Adult Africa South of the Sahara Ambulatory Care Facilities Contact Tracing Feasibility Studies Female HIV Infections Humans Penicillin G Benzathine Pregnancy Pregnancy Complications Infectious Pregnancy Outcome Prenatal Diagnosis Sexual Partners Surveys and Questionnaires Syphilis Urban Health Services Young Adult