Long-term expansion, genomic stability and in vivo safety of adult human pancreas organoids.
Nikitas Georgakopoulos,
Nicole Prior,
Brigitte Angres,
Gianmarco Mastrogiovanni,
Alex Cagan,
Daisy Harrison,
Christopher J Hindley,
Robert Arnes-Benito,
Siong-Seng Liau,
Abbie Curd,
Natasha Ivory,
Benjamin D Simons,
Inigo Martincorena,
Helmut Wurst,
Kourosh Saeb-Parsy,
Meritxell Huch
Mar 28, 2020
BACKGROUND:Pancreatic organoid systems have recently been described for the in vitro culture of pancreatic ductal cells from mouse and human. Mouse pancreatic organoids exhibit unlimited expansion potential, while previously...