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Cover Image for Spontaneous nucleation and fast aggregate-dependent proliferation of α-synuclein aggregates within liquid condensates at neutral pH.

Spontaneous nucleation and fast aggregate-dependent proliferation of α-synuclein aggregates within liquid condensates at neutral pH.

Samuel T Dada, Maarten C Hardenberg, Zenon Toprakcioglu, Lena K Mrugalla, Mariana P Cali, Mollie O McKeon, Ewa Klimont, Thomas C T Michaels, Tuomas P J Knowles, Michele Vendruscolo

Mar 23, 2023

The aggregation of α-synuclein into amyloid fibrils has been under scrutiny in recent years because of its association with Parkinson's disease. This process can be triggered by a lipid-dependent nucleation process, and the...

phase separation Parkinson’s disease Protein Condensates Humans Parkinson Disease Amyloid Cell Proliferation Kinetics Hydrogen-Ion Concentration ALPHA-SYNUCLEIN Protein Aggregates

Published by: Proceedings of the National Academy of Sciences of the United States of America