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Results: 17
Validity of ultrasonography to assess hepatic steatosis compared to magnetic resonance spectroscopy as a criterion method in older adults.
Emanuella De Lucia Rolfe, Soren Brage, Alison Sleigh, Francis Finucane, Simon J Griffin, Nick J Wareham, Ken K Ong, Nita G Forouhi
Dec 14, 2018
BACKGROUND: The rising prevalence of obesity has made hepatic steatosis an increasingly common issue. Ultrasound is generally used in clinical practice to assess steatosis, but its accuracy has been inconsistent across studies....
Temperature and pH-responsive nano-hydrogel drug delivery system based on lysine-modified poly (vinylcaprolactam).
Fatemeh Farjadian, Somayeh Rezaeifard, Mahsa Naeimi, Sahar Ghasemi, Soliman Mohammadi-Samani, Mark E Welland, Lobat Tayebi
Oct 28, 2019
BACKGROUND: Smart materials capable of responding to external stimuli are noteworthy candidates in designing drug delivery systems. In many of the recent research, temperature and pH have been recognized as the main stimulating...
DOX PVCL Raft Cancer Drug delivery Lysine Caprolactam Cell Death Doxorubicin Drug Carriers Drug Delivery Systems Drug Liberation Humans Hydrogels Hydrogen-Ion Concentration Lysine MCF-7 Cells Molecular Weight Nanoparticles Phase Transition Polymers Proton Magnetic Resonance Spectroscopy spectroscopy Fourier Transform Infrared Temperature Toxicity Tests
The interplay between metabolic alterations, diastolic strain rate and exercise capacity in mild heart failure with preserved ejection fraction
Masliza Mahmod, Nikhil Pal, Jennifer Rayner, Cameron Holloway, Betty Raman, Sairia Dass, Eylem Levelt, Rina Ariga, Vanessa Ferreira, Rajarshi Banerjee, Jurgen E Schneider, Christopher Rodgers, Jane M Francis, Theodoros D Karamitsos, Michael Frenneaux, Houman Ashrafian, Stefan Neubauer, Oliver Rider
Feb 11, 2019
BACKGROUND: Heart failure (HF) is characterized by altered myocardial substrate metabolism which can lead to myocardial triglyceride accumulation (steatosis) and lipotoxicity. However its role in mild HF with preserved ejection...
Cardiovascular magnetic resonance Diastolic strain rate Heart Failure Maximal oxygen consumption spectroscopy steatosis Adenosine Triphosphate Aged Biomarkers Biomechanical Phenomena Case-Control Studies Energy Metabolism Exercise Test Exercise Tolerance Female Heart Failure Humans Magnetic Resonance Imaging Cine Male Middle Aged Myocardial Contraction Myocardium Oxygen Consumption Phosphocreatine Predictive Value of Tests Prospective Studies Proton Magnetic Resonance Spectroscopy Severity of Illness Index Triglycerides Ventricular Function Left
Comparison of inter subject variability and reproducibility of whole brain proton spectroscopy.
Tonny V Veenith, Marius Mada, Eleanor Carter, Julia Grossac, Virginia Newcombe, Joanne Outtrim, Victoria Lupson, Sridhar Nallapareddy, Guy B Williams, Sulaiman Sheriff, David K Menon, Andrew A Maudsley, Jonathan P Coles
Feb 17, 2015
Exploration of human brain tumour metabolism using pairwise metabolite-metabolite correlation analysis (MMCA) of HR-MAS 1H NMR spectra.
METHODS: We quantified 378 HRMAS 1H NMR spectra of human brain tumours (132 glioblastomas, 101 astrocytomas, 75 meningiomas, 37 oligodendrogliomas and 33 metastases) from the eTumour database and looked for metabolic...
MRI measurements of reporter-mediated increases in transmembrane water exchange enable detection of a gene reporter.
Franz Schilling, Susana Ros, De-En Hu, Paula D'Santos, Sarah McGuire, Richard Mair, Alan J Wright, Elizabeth Mannion, Robin Jm Franklin, André A Neves, Kevin M Brindle
May 13, 2019
1H NMR spectroscopy-based metabolomics analysis for the diagnosis of symptomatic E. coli-associated urinary tract infection (UTI).
Milena Lussu, Tania Camboni, Cristina Piras, Corrado Serra, Francesco Del Carratore, Julian Griffin, Luigi Atzori, Aldo Manzin
Nov 21, 2018
BACKGROUND: Urinary tract infection (UTI) is one of the most common diagnoses in girls and women, and to a lesser extent in boys and men younger than 50 years. Escherichia coli, followed by Klebsiella spp. and Proteus spp....
1H NMR spectroscopy acetate E. coli ROC Curve Trimethylamine UTI Acetates Adult Aged Aged 80 and over Bacteria Bacteriuria Biomarkers Escherichia coli Escherichia coli Infections Female fungi Humans Male Metabolomics Methylamines Middle Aged Multivariate Analysis Proton Magnetic Resonance Spectroscopy ROC Curve Reference Values Sensitivity and Specificity Time Factors Urinary tract Urinary Tract Infections
Water-suppression cycling 3-T cardiac 1 H-MRS detects altered creatine and choline in patients with aortic or mitral stenosis.
Belinda Ding, Mark Peterzan, Ferenc E Mózes, Oliver J Rider, Ladislav Valkovič, Christopher T Rodgers
Mar 09, 2021
1H-MRS 3 T press STEAM cardiac Heart human water-suppression cycling Adult Aged aortic valve stenosis Choline Cohort Studies Creatine Female Healthy Volunteers Humans Male Metabolome Middle Aged Mitral Valve Stenosis Myocardium Phantoms imaging Proton Magnetic Resonance Spectroscopy Reproducibility of Results Signal-To-Noise Ratio water Young Adult
Proton magnetic resonance spectroscopy in frontotemporal lobar degeneration-related syndromes.
Alexander G Murley, Kamen A Tsvetanov, Matthew A Rouse, P Simon Jones, Katrine Sværke, Win Li, Adrian Carpenter, James B Rowe
Nov 19, 2021
There is an urgent need for a better understanding of the pathophysiology of cognitive impairment in syndromes associated with frontotemporal lobar degeneration. Here, we used magnetic resonance spectroscopy to quantify...
Behavioral variant frontotemporal dementia Corticobasal syndrome Frontotemporal Lobar Degeneration Glutamate progressive supranuclear palsy spectroscopy Aged Aspartic Acid Behavior Cognition Executive Function Female Frontotemporal Lobar Degeneration Glutamates Humans Male Middle Aged Prefrontal Cortex Primary visual cortex Proton Magnetic Resonance Spectroscopy Temporal Lobe
Fumarate metabolic signature for the detection of Reed Syndrome in humans
Ruth T Casey, Mary A McLean, Benjamin G Challis, Terri P McVeigh, Anne Y Warren, Lee Mendil, Richard Houghton, Stefano De Sanctis, Vasilis Kosmoliaptsis, Richard N Sandford, Ferdia A Gallagher, Eamonn R Maher
Oct 23, 2019
Interactions between callose and cellulose revealed through the analysis of biopolymer mixtures.
Radwa H Abou-Saleh, Mercedes C Hernandez-Gomez, Sam Amsbury, Candelas Paniagua, Matthieu Bourdon, Shunsuke Miyashima, Ykä Helariutta, Martin Fuller, Tatiana Budtova, Simon D Connell, Michael E Ries, Yoselin Benitez-Alfonso
Dec 18, 2018
The properties of (1,3)-β-glucans (i.e., callose) remain largely unknown despite their importance in plant development and defence. Here we use mixtures of (1,3)-β-glucan and cellulose, in ionic liquid solution and hydrogels, as...
1H, 15N and 13C resonance assignments of the HR1c domain of PRK1, a protein kinase C-related kinase.
Diminished Myoinositol in Ventromedial Prefrontal Cortex Modulates the Endophenotype of Impulsivity.
Bianca Jupp, Steve J Sawiak, Bastiaan van der Veen, Suzanne Lemstra, Chiara Toschi, Rebecca L Barlow, Anton Pekcec, Tom Bretschneider, Janet R Nicholson, Trevor W Robbins, Jeffrey W Dalley
Nov 28, 2019
attention-deficit hyperactivity disorder inositol monophosphatase 1 (IMPA1) inositol-triphosphate (IP3) Magnetic Resonance Spectroscopy Prefrontal Cortex Animals Attention CDP-Diacylglycerol-Inositol 3-Phosphatidyltransferase Endophenotypes Gene Knockdown Techniques Impulsive Behavior inositol Intramolecular Lyases Male Membrane Proteins Phosphoric Monoester Hydrolases Prefrontal Cortex Proton Magnetic Resonance Spectroscopy Rats Symporters
Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity.
Amberley D Stephens, Maria Zacharopoulou, Rani Moons, Giuliana Fusco, Neeleema Seetaloo, Anass Chiki, Philippa J Woodhams, Ioanna Mela, Hilal A Lashuel, Jonathan J Phillips, Alfonso De Simone, Frank Sobott, Gabriele S Kaminski Schierle
Apr 20, 2020
ApcMin/+ tumours and normal mouse small intestines show linear metabolite concentration and DNA cytosine hydroxymethylation gradients from pylorus to colon.