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Understanding influences on the uptake of pulmonary rehabilitation in the East of England
INTRODUCTION: 1.2 million people in the UK have chronic obstructive pulmonary disease (COPD) that causes breathlessness, difficulty with daily activities, infections and hospitalisation. Pulmonary rehabilitation (PR), a...
Biomarkers and clinical outcomes in COPD
Jilles M Fermont, Katya L Masconi, Magnus T Jensen, Renata Ferrari, Valéria AP Di Lorenzo, Jacob M Marott, Philipp Schuetz, Henrik Watz, Benjamin Waschki, Hana Müllerova, Michael I Polkey, Ian B Wilkinson, Angela M Wood
Jan 17, 2019
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
Nick Shrine, Anna L Guyatt, A Mesut Erzurumluoglu, Victoria E Jackson, Brian D Hobbs, Carl A Melbourne, Chiara Batini, Katherine A Fawcett, Kijoung Song, Phuwanat Sakornsakolpat, Xingnan Li, Ruth Boxall, Nicola F Reeve, Ma'en Obeidat, Jing Hua Zhao, Matthias Wielscher, Stefan Weiss, Katherine A Kentistou, James P Cook, Benjamin B Sun, Jian Zhou, Jennie Hui, Stefan Karrasch, Medea Imboden, Sarah E Harris, Jonathan Marten, Stefan Enroth, Shona M Kerr, Ida Surakka, Veronique Vitart, Terho Lehtimäki, Richard J Allen, Per S Bakke, Terri H Beaty, Eugene R Bleecker, Yohan Bossé, Corry-Anke Brandsma, Zhengming Chen, James D Crapo, John Danesh, Dawn L DeMeo, Frank Dudbridge, Ralf Ewert, Christian Gieger, Amund Gulsvik, Anna L Hansell, Ke Hao, Joshua D Hoffman, John E Hokanson, Georg Homuth, Peter K Joshi, Philippe Joubert, Claudia Langenberg, Xuan Li, Liming Li, Kuang Lin, Lars Lind, Nicholas Locantore, Jian'an Luan, Anubha Mahajan, Joseph C Maranville, Alison Murray, David C Nickle, Richard Packer, Margaret M Parker, Megan L Paynton, David J Porteous, Dmitry Prokopenko, Dandi Qiao, Rajesh Rawal, Heiko Runz, Ian Sayers, Don D Sin, Blair H Smith, María Soler Artigas, David Sparrow, Ruth Tal-Singer, Paul RHJ Timmers, Maarten van den Berge, John C Whittaker, Prescott G Woodruff, Laura M Yerges-Armstrong, Olga G Troyanskaya, Olli T Raitakari, Mika Kähönen, Ozren Polašek, Ulf Gyllensten, Igor Rudan, Ian J Deary, Nicole M Probst-Hensch, Holger Schulz, Alan L James, James F Wilson, Beate Stubbe, Eleftheria Zeggini, Marjo-Riitta Jarvelin, Nick Wareham, Edwin K Silverman, Caroline Hayward, Andrew P Morris, Adam S Butterworth, Robert A Scott, Robin G Walters, Deborah A Meyers, Michael H Cho, David P Strachan, Ian P Hall, Martin D Tobin, Louise V Wain, Understanding Society Scientific Group
Jan 21, 2019
Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of European ancestry, we define 279 lung function...
Withdrawal of inhaled glucocorticoids and exacerbations of COPD.
Helgo Magnussen, Bernd Disse, Roberto Rodriguez-Roisin, Anne Kirsten, Henrik Watz, Kay Tetzlaff, Lesley Towse, Helen Finnigan, Ronald Dahl, Marc Decramer, Pascal Chanez, Emiel FM Wouters, Peter MA Calverley, WISDOM Investigators
Jan 22, 2016
Administration Inhalation Aged Albuterol Androstadienes Bronchodilator Agents Double-Blind Method Drug Therapy Combination Female Fluticasone Forced Expiratory Volume Glucocorticoids Humans Male Middle Aged Proportional Hazards Models Pulmonary Disease Chronic Obstructive Salmeterol Xinafoate Scopolamine Derivatives Spirometry Tiotropium Bromide Withholding Treatment
What influenced people with chronic or refractory breathlessness and advanced disease to take part and remain in a drug trial? A qualitative study.
BACKGROUND: Recruitment and retention in clinical trials remains an important challenge, particularly in the context of advanced disease. It is important to understand what affects retention to improve trial quality, minimise...
breathlessness Palliative Care person-centred care Qualitative randomised controlled trial Recruitment Retention Aged Aged 80 and over Chronic Disease Double-Blind Method Dyspnea Feasibility Studies Female Heart Failure Humans Lung Diseases Interstitial Male Middle Aged motivation Neoplasms Patient Participation Pulmonary Disease Chronic Obstructive qualitative research Quality of life Severity of Illness Index Surveys and Questionnaires United Kingdom
Predicting 10-year stroke mortality
Weronika A Szlachetka, Tiberiu A Pana, Mamas A Mamas, Joao H Bettencourt-Silva, Anthony K Metcalf, John F Potter, David J McLernon, Phyo K Myint
Jun 07, 2022
Predicting long-term stroke mortality is a clinically important and unmet need. We aimed to develop and internally validate a 10-year ischaemic stroke mortality prediction score. In this UK cohort study, 10,366 patients with...
Cerebrovascular disease Ischaemic stroke long-term mortality Prediction score Prognosis Aged Aged 80 and over Atrial fibrillation Brain Ischemia Cohort Studies Coronary Disease Female Heart Failure Humans Hypertension ischemic stroke Male Nomograms peripheral vascular diseases Pulmonary Disease Chronic Obstructive Risk Factors stroke
The effects of maintenance schedules following pulmonary rehabilitation in patients with chronic obstructive pulmonary disease
Andrew M Wilson, Paula Browne, Sandra Olive, Allan Clark, Penny Galey, Emma Dix, Helene Woodhouse, Sue Robinson, Edward Cf Wilson, Lindi Staunton
May 04, 2015
Activities of Daily Living Adipose Tissue Aged Aged 80 and over Anxiety Appointments and Schedules Body Mass Index Depression Dyspnea Exercise Test Exercise Therapy Female Forced Expiratory Volume Hospitalization Humans Male Middle Aged Patient Education as Topic Physical Fitness Program Evaluation Pulmonary Disease Chronic Obstructive Quality of life Surveys and Questionnaires Walking
Fibrinogen does not relate to cardiovascular or muscle manifestations in COPD
Divya Mohan, Julia R Forman, Matthew Allinder, Carmel M McEniery, Charlotte Emma Bolton, John R Cockcroft, William MacNee, Jonathan Fuld, Mellone Marchong, Nichola Sian Gale, Marie Fisk, Sridevi Nagarajan, Joseph Cheriyan, David A Lomas, Peter MA Calverley, Bruce E Miller, Ruth Tal-Singer, Ian B Wilkinson, Michael I Polkey, ERICA Consortium
Sep 11, 2018
Cardiovascular and skeletal muscle manifestations constitute important comorbidities in COPD, with systemic inflammation proposed as a common mechanistic link. Fibrinogen has prognostic role in COPD. We aimed to determine...
Attitudes to specialist palliative care and advance care planning in people with COPD
Natasha Smallwood, David Currow, Sara Booth, Anna Spathis, Louis Irving, Jennifer Philip
Dec 07, 2018
BACKGROUND: Chronic obstructive pulmonary disease (COPD) guidelines recommend early access to palliative care together with optimal, disease-directed therapy for people with advanced disease, however, this occurs infrequently....
advance care planning attitudes COPD health professionals Palliative Care Survey Adult advance care planning Attitude of Health Personnel Australia Disease Progression Female Humans Interdisciplinary Communication Male Needs Assessment New Zealand Palliative Medicine Pulmonary Disease Chronic Obstructive Pulmonary Medicine qualitative research Quality Improvement Terminal Care United Kingdom
Supportive and palliative care of adults with respiratory problems experiencing structural vulnerability from homelessness, prison or other criminal justice system involvement.
'I'm fine!': Assertions of lack of support need among patients with chronic obstructive pulmonary disease
A Carole Gardener, Caroline Moore, Morag Farquhar, Gail Ewing, Efthalia Massou, Robbie Duschinsky
Aug 23, 2022
Mechanisms of Vascular Dysfunction in COPD and Effects of a Novel Soluble Epoxide Hydrolase Inhibitor in Smokers.
Lucy Yang, Joseph Cheriyan, David D Gutterman, Ruth J Mayer, Zsuzsanna Ament, Jules L Griffin, Aili L Lazaar, David E Newby, Ruth Tal-Singer, Ian B Wilkinson
Jan 25, 2017
COPD EETs clinical trial endothelial function smokers soluble epoxide hydrolase inhibitor 8 11 14-Eicosatrienoic Acid Adult Aged blood vessels Bradykinin Case-Control Studies Cyclohexylamines Endothelium Vascular Epoxide Hydrolases Fluconazole Forearm Humans In Vitro Techniques Male Middle Aged Overweight Plethysmography Pulmonary Disease Chronic Obstructive Smoking Triazines Vasodilation Vasodilator Agents
Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations.
Phuwanat Sakornsakolpat, Dmitry Prokopenko, Maxime Lamontagne, Nicola F Reeve, Anna L Guyatt, Victoria E Jackson, Nick Shrine, Dandi Qiao, Traci M Bartz, Deog Kyeom Kim, Mi Kyeong Lee, Jeanne C Latourelle, Xingnan Li, Jarrett D Morrow, Ma'en Obeidat, Annah B Wyss, Per Bakke, R Graham Barr, Terri H Beaty, Steven A Belinsky, Guy G Brusselle, James D Crapo, Kim de Jong, Dawn L DeMeo, Tasha E Fingerlin, Sina A Gharib, Amund Gulsvik, Ian P Hall, John E Hokanson, Woo Jin Kim, David A Lomas, Stephanie J London, Deborah A Meyers, George T O'Connor, Stephen I Rennard, David A Schwartz, Pawel Sliwinski, David Sparrow, David P Strachan, Ruth Tal-Singer, Yohannes Tesfaigzi, Jørgen Vestbo, Judith M Vonk, Jae-Joon Yim, Xiaobo Zhou, Yohan Bossé, Ani Manichaikul, Lies Lahousse, Edwin K Silverman, H Marike Boezen, Louise V Wain, Martin D Tobin, Brian D Hobbs, Michael H Cho, SpiroMeta Consortium, International COPD Genetics Consortium
Jan 13, 2020
Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed a genome-wide association study in 35,735 cases...
Communicating uncertainty
Nothando Ngwenya, Clare Crang, Morag Farquhar, Robert C Rintoul, Ravi Mahadeva, Lori D Calvert, Scott A Murray, Stephen Barclay
Mar 08, 2021
BACKGROUND: Due to the uncertain disease trajectory and variable rate of progression in chronic obstructive pulmonary disease (COPD), health care professionals (HCPs) are challenged in explaining what the future may hold for...
Effect of Monthly Vitamin D Supplementation on Preventing Exacerbations of Asthma or Chronic Obstructive Pulmonary Disease in Older Adults
Carlos A Camargo, Les Toop, John Sluyter, Carlene MM Lawes, Debbie Waayer, Kay-Tee Khaw, Adrian R Martineau, Robert Scragg
Feb 07, 2021
Randomized controlled trials have suggested that vitamin D supplementation can prevent asthma and chronic obstructive pulmonary disease (COPD) exacerbations. For COPD, the benefit appears to be limited to individuals with...
Asthma Chronic obstructive pulmonary disease exacerbations oral corticosteroids Randomized controlled trial supplement vitamin D Aged Asthma Dietary Supplements Double-Blind Method Drug Administration Schedule Female Humans Male Middle Aged Proportional Hazards Models Pulmonary Disease Chronic Obstructive Secondary Prevention Symptom Flare Up Treatment Outcome vitamin D Vitamin D Deficiency Vitamins
Understanding the Influences of COPD Patient's Capability on the Uptake of Pulmonary Rehabilitation in the UK Through an Inclusive Design Approach.
Yuanyuan Liu, Terry Dickerson, Frances Early, Jonathan Fuld, Chen Jiang, P John Clarkson
Apr 20, 2021
BACKGROUND: Pulmonary rehabilitation (PR) is recommended for patients with COPD to improve their symptoms and quality of life. However, in the UK, only one in ten of those who need PR receive it and this might be inaccessible to...
To What Extent Do the NRS and CRQ Capture Change in Patients' Experience of Breathlessness in Advanced Disease? Findings From a Mixed-Methods Double-Blind Randomized Feasibility Trial.
Natasha Lovell, Simon Noah Etkind, Sabrina Bajwah, Matthew Maddocks, Irene Julie Higginson
Dec 21, 2020
CONTEXT: Chronic or refractory breathlessness is common and distressing. To evaluate new treatments, outcome measures that capture change in patients' experience are needed. OBJECTIVES: To explore the extent to which the...
breathlessness advanced disease outcome measure Randomized controlled trial Shortness of breath Aged Aged 80 and over Chronic Disease Double-Blind Method Dyspnea Feasibility Studies Female Heart Failure Humans Lung Diseases Interstitial Male Middle Aged Neoplasms Pulmonary Disease Chronic Obstructive Quality of life Severity of Illness Index Surveys and Questionnaires
Accelerated FEV1 decline and risk of cardiovascular disease and mortality in a primary care population of COPD patients.
Hannah R Whittaker, Chloe Bloom, Ann Morgan, Deborah Jarvis, Steven J Kiddle, Jennifer K Quint
Oct 21, 2020
Accelerated lung function decline has been associated with increased risk of cardiovascular disease (CVD) in a general population, but little is known about this association in chronic obstructive pulmonary disease (COPD). We...
Specialty COPD care during COVID-19
Frances Wu, Jenni Burt, Teena Chowdhury, Raymond Fitzpatrick, Graham Martin, Jan W van der Scheer, John R Hurst
Jan 11, 2021
INTRODUCTION: The COVID-19 pandemic has impacted specialty chronic obstructive pulmonary disease (COPD) care. We examined the degree to which care has moved to remote approaches, eliciting clinician and patient perspectives on...
Humans Pulmonary Disease Chronic Obstructive Severity of Illness Index Attitude of Health Personnel Attitude to Health Smoking Cessation Telemedicine Adult Aged Middle Aged Nurses Physicians Delivery of Health Care Patient Acceptance of Health Care Female Male Patient Education as Topic Physical therapists Surveys and Questionnaires Practice Patterns Nurses' Practice Patterns Physicians' United Kingdom self-management covid-19 SARS-CoV-2
Surfactant protein D is a causal risk factor for COPD
Ma'en Obeidat, Xuan Li, Stephen Burgess, Guohai Zhou, Nick Fishbane, Nadia N Hansel, Yohan Bossé, Philippe Joubert, Ke Hao, David C Nickle, Maarten van den Berge, Wim Timens, Michael H Cho, Brian D Hobbs, Kim de Jong, Marike Boezen, Rayjean J Hung, Nicholas Rafaels, Rasika Mathias, Ingo Ruczinski, Terri H Beaty, Kathleen C Barnes, Peter D Paré, Don D Sin, Lung eQTL Consortium, Lung Health Study International COPD Genetics Consortium
Jul 25, 2018
Surfactant protein D (SP-D) is produced primarily in the lung and is involved in regulating pulmonary surfactants, lipid homeostasis and innate immunity. Circulating SP-D levels in blood are associated with chronic obstructive...
Research in progress--LungSEARCH
UNLABELLED: Low-dose CT screening for lung cancer is effective but expensive. Therefore, cheaper or more focused screening strategies may be required. LungSEARCH is a randomised prospective trial of 1568 high-risk individuals...
Surrogate Markers of Cardiovascular Risk and Chronic Obstructive Pulmonary Disease
Marie Fisk, Carmel M McEniery, Nichola Gale, Kaisa Mäki-Petäjä, Julia R Forman, Margaret Munnery, Jean Woodcock-Smith, Joseph Cheriyan, Divya Mohan, Jonathan Fuld, Ruth Tal-Singer, Michael I Polkey, John R Cockcroft, Ian B Wilkinson, ERICA Consortium and ACCT Investigators
Feb 06, 2018
Cardiovascular disease is a common comorbidity and cause of mortality in chronic obstructive pulmonary disease. A better understanding of mechanisms of cardiovascular risk in chronic obstructive pulmonary disease patients is...
Cardiovascular Diseases Carotid Intima-Media Thickness Case-Control Studies Pulmonary Disease Chronic Obstructive Pulse Wave Analysis Age Factors Aged Biomarkers Cardiovascular Diseases Carotid Intima-Media Thickness Case-Control Studies Comorbidity Female Hemodynamics Humans Incidence Male Middle Aged Pulmonary Disease Chronic Obstructive Reference Values Respiratory Function Tests Retrospective Studies Risk Assessment Severity of Illness Index Sex Factors Smoking Survival Rate United Kingdom Vascular Stiffness
Characterisation of COPD heterogeneity in the ECLIPSE cohort.
Alvar Agusti, Peter MA Calverley, Bartolome Celli, Harvey O Coxson, Lisa D Edwards, David A Lomas, William MacNee, Bruce E Miller, Steve Rennard, Edwin K Silverman, Ruth Tal-Singer, Emiel Wouters, Julie C Yates, Jørgen Vestbo, Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) investigators
Jun 16, 2011
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