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Results: 28
Modeling arterial pulse waves in healthy aging
Peter H Charlton, Jorge Mariscal Harana, Samuel Vennin, Ye Li, Phil Chowienczyk, Jordi Alastruey
Sep 11, 2020
The arterial pulse wave (PW) is a rich source of information on cardiovascular (CV) health. It is widely measured by both consumer and clinical devices. However, the physical determinants of the PW are not yet fully understood...
Association of aortic stiffness with cognitive decline
Marzieh Araghi, Martin J Shipley, Ian B Wilkinson, Carmel M McEniery, Carlos A Valencia-Hernández, Mika Kivimaki, Séverine Sabia, Archana Singh-Manoux, Eric J Brunner
Nov 13, 2019
Aortic stiffness is associated with an increased risk of cardio- and cerebrovascular disease and mortality and may increase risk of dementia. The aim of the present study is to examine the association between arterial stiffness...
Ageing arterial stiffness cognitive decline Pulse-wave velocity Aged arteries Cognition Cognitive Dysfunction Cohort Studies Female Health Behavior Humans Longitudinal Studies Male Memory Disorders Middle Aged Prospective Studies Pulse Wave Analysis Risk Factors Severity of Illness Index Vascular Stiffness
Stiffening and ventricular-arterial interaction in the ascending aorta using MRI
OBJECTIVES: The aim of this study was to investigate the effect of age and sex on nPWV and ndI in the ascending aorta of healthy humans. BACKGROUND: Local pulse wave velocity (nPWV) and wave intensity (ndI) in the human...
Blueberries improve biomarkers of cardiometabolic function in participants with metabolic syndrome-results from a 6-month, double-blind, randomized controlled trial.
Peter J Curtis, Vera van der Velpen, Lindsey Berends, Amy Jennings, Martin Feelisch, A Margot Umpleby, Mark Evans, Bernadette O Fernandez, Mia S Meiss, Magdalena Minnion, John Potter, Anne-Marie Minihane, Colin D Kay, Eric B Rimm, Aedín Cassidy
Jan 28, 2019
Metabolic Syndrome blueberry anthocyanins Flavonoids cardiovascular disease risk anthocyanin-derived phenolic acid metabolites Aged Apolipoproteins Biomarkers blood pressure Blueberry Plants Cholesterol HDL Cholesterol LDL Double-Blind Method Female Fruit Heart Humans Insulin Resistance Male Metabolic Syndrome Middle Aged Prospective Studies Pulse Wave Analysis
Fibrinogen does not relate to cardiovascular or muscle manifestations in COPD
Divya Mohan, Julia R Forman, Matthew Allinder, Carmel M McEniery, Charlotte Emma Bolton, John R Cockcroft, William MacNee, Jonathan Fuld, Mellone Marchong, Nichola Sian Gale, Marie Fisk, Sridevi Nagarajan, Joseph Cheriyan, David A Lomas, Peter MA Calverley, Bruce E Miller, Ruth Tal-Singer, Ian B Wilkinson, Michael I Polkey, ERICA Consortium
Sep 11, 2018
Cardiovascular and skeletal muscle manifestations constitute important comorbidities in COPD, with systemic inflammation proposed as a common mechanistic link. Fibrinogen has prognostic role in COPD. We aimed to determine...
A randomized, multicenter, open-label, blinded end point trial comparing the effects of spironolactone to chlorthalidone on left ventricular mass in patients with early-stage chronic kidney disease
MK Hayer, NC Edwards, G Slinn, WE Moody, RP Steeds, CJ Ferro, AM Price, C Andujar, M Dutton, R Webster, DJ Webb, S Semple, I MacIntyre, V Melville, IB Wilkinson, TF Hiemstra, DC Wheeler, A Herrey, M Grant, S Mehta, N Ives, JN Townend
Aug 31, 2017
Adult Aged Chlorthalidone Dose-Response Relationship Drug Drug Therapy Combination Female Follow-Up Studies Heart Ventricles Humans hypertrophy Left Ventricular Kidney Failure Chronic Magnetic Resonance Imaging Cine Male Middle Aged Mineralocorticoid Receptor Antagonists Prospective Studies Pulse Wave Analysis Single-Blind Method Sodium Chloride Symporter Inhibitors Spironolactone Survival Rate Time Factors Treatment Outcome United States Vascular Stiffness
Early changes in cardiovascular structure and function in adolescents with type 1 diabetes.
Timothy J Bradley, Cameron Slorach, Farid H Mahmud, David B Dunger, John Deanfield, Livia Deda, Yesmino Elia, Ronnie LH Har, Wei Hui, Rahim Moineddin, Heather N Reich, James W Scholey, Luc Mertens, Etienne Sochett, David ZI Cherney
Sep 29, 2016
Adolescent Age Factors blood pressure Case-Control Studies Child Diabetes mellitus Type 1 Disease Progression Early Diagnosis Echocardiography Doppler Female Humans Longitudinal Studies Male Mitral Valve Myocardial Contraction Peripheral Arterial Disease Predictive Value of Tests Pulse Wave Analysis Risk Factors Stress Mechanical Vascular Stiffness Vasodilation Ventricular Dysfunction Left Ventricular Function Left
Vascular Effects of ACE (Angiotensin-Converting Enzyme) Inhibitors and Statins in Adolescents With Type 1 Diabetes.
Scott T Chiesa, M Loredana Marcovecchio, Paul Benitez-Aguirre, Fergus J Cameron, Maria E Craig, Jennifer J Couper, Elizabeth A Davis, R Neil Dalton, Denis Daneman, Kim C Donaghue, Timothy W Jones, Farid H Mahmud, Sally M Marshall, H Andrew W Neil, David B Dunger, John E Deanfield, Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT) Study Group
Nov 03, 2020
An increased albumin-creatinine ratio within the normal range can identify adolescents at higher risk of developing adverse cardio-renal outcomes as they progress into adulthood. Utilizing a parallel randomized controlled trial...
Adolescent arteries Diabetes Type 1 Puberty Vascular diseases Adolescent Albuminuria Angiotensin-Converting Enzyme Inhibitors C-Reactive Protein Creatinine Diabetes mellitus Type 1 Double-Blind Method Drug Therapy Combination Endothelium Vascular Female Glycated Hemoglobin Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Lipids Male Pulse Wave Analysis Vascular Stiffness
Surrogate Markers of Cardiovascular Risk and Chronic Obstructive Pulmonary Disease
Marie Fisk, Carmel M McEniery, Nichola Gale, Kaisa Mäki-Petäjä, Julia R Forman, Margaret Munnery, Jean Woodcock-Smith, Joseph Cheriyan, Divya Mohan, Jonathan Fuld, Ruth Tal-Singer, Michael I Polkey, John R Cockcroft, Ian B Wilkinson, ERICA Consortium and ACCT Investigators
Feb 06, 2018
Cardiovascular disease is a common comorbidity and cause of mortality in chronic obstructive pulmonary disease. A better understanding of mechanisms of cardiovascular risk in chronic obstructive pulmonary disease patients is...
Cardiovascular Diseases Carotid Intima-Media Thickness Case-Control Studies Pulmonary Disease Chronic Obstructive Pulse Wave Analysis Age Factors Aged Biomarkers Cardiovascular Diseases Carotid Intima-Media Thickness Case-Control Studies Comorbidity Female Hemodynamics Humans Incidence Male Middle Aged Pulmonary Disease Chronic Obstructive Reference Values Respiratory Function Tests Retrospective Studies Risk Assessment Severity of Illness Index Sex Factors Smoking Survival Rate United Kingdom Vascular Stiffness
Socioeconomic status, education, and aortic stiffness progression over 5 years
OBJECTIVE: The inverse association between socioeconomic status (SES) and cardiovascular disease (CVD) risk is well documented. Aortic stiffness assessed by aortic pulse wave velocity (PWV) is a strong predictor of CVD events....
Disconnection of pulmonary and systemic arterial stiffness in COPD.
Jonathan R Weir-McCall, Patrick Sk Liu-Shiu-Cheong, Allan D Struthers, Brian J Lipworth, J Graeme Houston
Sep 30, 2019
BACKGROUND: Both pulmonary arterial stiffening and systemic arterial stiffening have been described in COPD. The aim of the current study was to assess pulse wave velocity (PWV) within these two arterial beds to determine...
COPD arterial compliance Cardiovascular pulmonary vascular Ventricular Function Adult Aged Aged 80 and over Case-Control Studies Forced Expiratory Volume Germany Heart Humans Magnetic Resonance Imaging Male Middle Aged Organ Size Pulmonary Disease Chronic Obstructive Pulse Wave Analysis Spirometry Vascular Stiffness
Pulmonary arterial stiffening in COPD and its implications for right ventricular remodelling.
Jonathan R Weir-McCall, Patrick Sk Liu-Shiu-Cheong, Allan D Struthers, Brian J Lipworth, J Graeme Houston
Oct 03, 2019
BACKGROUND: Pulmonary pulse wave velocity (PWV) allows the non-invasive measurement of pulmonary arterial stiffening, but has not previously been assessed in COPD. The aim of the current study was to assess PWV in COPD and its...
Heart Ventricles Magnetic Resonance Imaging Pulmonary arteries Pulmonary Disease Chronic Obstructive Pulse-wave analysis Aged Female Heart Ventricles Humans Magnetic Resonance Imaging Male Middle Aged Pulmonary Artery Pulmonary Disease Chronic Obstructive Pulse Wave Analysis Respiratory Function Tests Ventricular Remodeling
Mitochondria-targeted antioxidant therapy with MitoQ ameliorates aortic stiffening in old mice.
Rachel A Gioscia-Ryan, Micah L Battson, Lauren M Cuevas, Jason S Eng, Michael P Murphy, Douglas R Seals
Jun 18, 2018
Aortic stiffening is a major independent risk factor for cardiovascular diseases, cognitive dysfunction, and other chronic disorders of aging. Mitochondria-derived reactive oxygen species are a key source of arterial oxidative...
The age-dependent association between aortic pulse wave velocity and telomere length.
Barry J McDonnell, Yasmin, Lee Butcher, John R Cockcroft, Ian B Wilkinson, Jorge D Erusalimsky, Carmel M McEniery
Feb 17, 2017
The Role of the Autonomic Nervous System in the Regulation of Aortic Stiffness.
Kaisa M Mäki-Petäjä, Sharon ML Barrett, Sarah V Evans, Joseph Cheriyan, Carmel M McEniery, Ian B Wilkinson
Oct 14, 2016
aortic stiffness Autonomic Nervous System blood pressure Healthy Volunteers Heart Rate Hemodynamics Adult Arterial Pressure Autonomic Nervous System Cross-Over Studies Cross-Sectional Studies Double-Blind Method Female Hand Strength Healthy Volunteers Heart Rate Hemodynamics Humans Hypertension Male Pentolinium Tartrate Prognosis Pulse Wave Analysis Role Vascular Stiffness Young Adult
Epicardial adipose tissue is related to arterial stiffness and inflammation in patients with cardiovascular disease and type 2 diabetes.
Shaween Al-Talabany, Ify Mordi, J Graeme Houston, Helen M Colhoun, Jonathan R Weir-McCall, Shona Z Matthew, Helen C Looker, Daniel Levin, Jill JF Belch, Fiona Dove, Faisel Khan, Chim C Lang
Sep 30, 2019
BACKGROUND: Epicardial adipose tissue (EAT) is an emerging cardio-metabolic risk factor and has been shown to correlate with adverse cardiovascular (CV) outcome; however the underlying pathophysiology of this link is not well...
arterial stiffness Cardiovascular magnetic resonance Epicardial adipose tissue Left ventricular mass pulse wave velocity type 2 diabetes mellitus Adipose Tissue Adiposity Aged Cardiovascular Diseases Case-Control Studies Diabetes mellitus Type 2 Female Humans Inflammation Magnetic Resonance Imaging Cine Male Middle Aged Pericardium Pulse Wave Analysis Risk Factors Scotland Vascular Stiffness
Development and Validation of a Path Length Calculation for Carotid-Femoral Pulse Wave Velocity Measurement
Jonathan R Weir-McCall, Liam Brown, Jennifer Summersgill, Piotr Talarczyk, Michael Bonnici-Mallia, Sook C Chin, Faisel Khan, Allan D Struthers, Frank Sullivan, Helen M Colhoun, Angela C Shore, Kunihiko Aizawa, Leif Groop, Jan Nilsson, John R Cockcroft, Carmel M McEniery, Ian B Wilkinson, Yoav Ben-Shlomo, J Graeme Houston
Jun 12, 2018
Current distance measurement techniques for pulse wave velocity (PWV) calculation are susceptible to intercenter variability. The aim of this study was to derive and validate a formula for this distance measurement. Based on...
arteriosclerosis Atherosclerosis Cardiovascular Diseases Hypertension Magnetic Resonance Angiography Pulse Wave Analysis Adult Age Factors Aged Analysis of Variance Blood Flow Velocity blood pressure Blood Pressure Determination Carotid Arteries Cohort Studies Female Femoral Artery Humans Logistic Models Magnetic Resonance Angiography Male Middle Aged Prospective Studies Pulse Wave Analysis Risk Assessment Sex Factors Vascular Stiffness Whole Body Imaging
NG Forouhi, RK Menon, SJ Sharp, N Mannan, PM Timms, AR Martineau, AP Rickard, BJ Boucher, TA Chowdhury, CJ Griffiths, SE Greenwald, SJ Griffin, GA Hitman
Jan 08, 2016
intervention placebo pulse wave velocity randomized trial Type 2 diabetes vitamin D2 vitamin D3 25-Hydroxyvitamin D 2 Adult Aged Calcifediol Cardiovascular Diseases Cholecalciferol Cohort Studies Diabetes mellitus Type 2 Dietary Supplements Double-Blind Method England Ergocalciferols Feasibility Studies Female Follow-Up Studies Glycated Hemoglobin Humans Male Middle Aged Pulse Wave Analysis risk Vascular Stiffness
Effects of contrast administration on cardiac MRI volumetric, flow and pulse wave velocity quantification using manual and software-based analysis.
Amir Fathi, Jonathan R Weir-McCall, Allan D Struthers, Brian J Lipworth, Graeme Houston
Oct 07, 2019
OBJECTIVE: The aim of the current study was to determine the effects of gadolinium contrast agent on right (RV) and left ventricular (LV) volumetric, aortic flow and pulse wave velocity (PWV) quantification using manual...
Functional characterization of common BCL11B gene desert variants suggests a lymphocyte-mediated association of BCL11B with aortic stiffness.
Raya Al Maskari, Iris Hardege, Sarah Cleary, Nicki Figg, Ye Li, Keith Siew, Ashraf Khir, Yong Yu, Pentao Liu, Ian Wilkinson, Kevin O'Shaughnessy, Yasmin
Sep 05, 2018
Respiratory and Cardiovascular Outcomes in Survivors of Extremely Preterm Birth at 19 Years.
John R Hurst, Joanne Beckmann, Yanyan Ni, Charlotte E Bolton, Carmel M McEniery, John R Cockcroft, Neil Marlow
Apr 21, 2020
Rationale: Growth and development during adolescence may modify the respiratory and vascular differences seen among extremely preterm (EP) individuals in childhood and early adolescence.Objectives: To assess the trajectory of...
adult outcomes cardiovascular function extreme prematurity lung function Asthma blood pressure Breath Tests bronchopulmonary dysplasia C-Reactive Protein Cardiovascular Diseases Cohort Studies Creatinine Exercise Tolerance Female Forced Expiratory Volume Glomerular Filtration Rate Humans Infant Extremely Premature Infant Newborn Inflammation Ireland Longitudinal Studies Lung Male Manometry Maximal Midexpiratory Flow Rate Nitric oxide Pulse Wave Analysis Spirometry United Kingdom Vascular Resistance Vital Capacity Walk Test Young Adult
Isolated systolic hypertension in the young
Paolo Palatini, Enrico Agabiti Rosei, Alberto Avolio, Gregorz Bilo, Edoardo Casiglia, Lorenzo Ghiadoni, Cristina Giannattasio, Guido Grassi, Bojan Jelakovich, Stevo Julius, Giuseppe Mancia, Carmel M McEniery, Michael F O'Rourke, Gianfranco Parati, Paolo Pauletto, Giacomo Pucci, Francesca Saladini, Pasquale Strazzullo, Konstantinos Tsioufis, Ian B Wilkinson, Alberto Zanchetti
Nov 21, 2018
Whether isolated systolic hypertension in the young (ISHY) implies a worse outcome and needs antihypertensive treatment is still a matter for dispute. ISHY is thought to have different mechanisms than systolic hypertension in...
Impaired renal function impacts negatively on vascular stiffness in patients with coronary artery disease.
Sabrina H Rossi, Emily P McQuarrie, William H Miller, Ruth M Mackenzie, Jane A Dymott, María U Moreno, Chiara Taurino, Ashley M Miller, Ulf Neisius, Geoffrey A Berg, Zivile Valuckiene, Jonathan A Hannay, Anna F Dominiczak, Christian Delles
Jul 27, 2018
BACKGROUND: Chronic kidney disease (CKD) and coronary artery disease (CAD) are independently associated with increased vascular stiffness. We examined whether renal function contributes to vascular stiffness independently of CAD...
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