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Long-Term Costs and Health Consequences of Issuing Shorter Duration Prescriptions for Patients with Chronic Health Conditions in the English NHS.
BACKGROUND: The National Health Service (NHS) in England spends over £9 billion on prescription medicines dispensed in primary care, of which over two-thirds is accounted for by repeat prescriptions. Recently, GPs in England...
mHealth and global mental health
Background
Two phenomena have become increasingly visible over the past decade: the significant global burden of disease arising from mental illness and the rapid acceleration of mobile phone usage in poorer countries. Mental...
Cost-effectiveness of intensive multifactorial treatment compared with routine care for individuals with screen-detected Type 2 diabetes
L Tao, ECF Wilson, NJ Wareham, A Sandbaek, GEHM Rutten, T Lauritzen, K Khunti, MJ Davies, K Borch-Johnsen, SJ Griffin, RK Simmons
Aug 11, 2014
Aged Cluster Analysis Cohort Studies Combined Modality Therapy Cost-Benefit Analysis Diabetes Complications Diabetes mellitus Type 2 Female Health Care Costs Humans Incidence Male Mass Screening Middle Aged Patient Education as Topic Patient-Centered Care Quality-Adjusted Life Years Risk Factors Time Factors United Kingdom
The greatest health problem of the Middle Ages? Estimating the burden of disease in medieval England.
OBJECTIVE: To identify the major health problems of the Middle Ages. Bubonic plague is often considered the greatest health disaster in medieval history, but this has never been systematically investigated. MATERIALS: We...
Cost-effectiveness of self-management of blood pressure in hypertensive patients over 70 years with suboptimal control and established cardiovascular disease or additional cardiovascular risk diseases (TASMIN-SR).
Maria Cristina Penaloza-Ramos, Sue Jowett, Jonathan Mant, Claire Schwartz, Emma P Bray, M Sayeed Haque, FD Richard Hobbs, Paul Little, Stirling Bryan, Bryan Williams, Richard J McManus
Nov 05, 2015
Hypertension cost-effectiveness decision analysis decision model self-management Age Factors Aged Aged 80 and over Antihypertensive Agents blood pressure Cost-Benefit Analysis Decision Support Techniques Drug Costs Female Humans Hypertension Male Markov Chains Models Economic Process Assessment Health Care Quality-Adjusted Life Years Self Care Time Factors Treatment Outcome United Kingdom
Multilevel models for cost-effectiveness analyses that use cluster randomised trial data
Edmond S-W Ng, Karla Diaz-Ordaz, Richard Grieve, Richard M Nixon, Simon G Thompson, James R Carpenter
Nov 16, 2017
Multilevel models provide a flexible modelling framework for cost-effectiveness analyses that use cluster randomised trial data. However, there is a lack of guidance on how to choose the most appropriate multilevel models. This...
Cost effectiveness of population based BRCA1 founder mutation testing in Sephardi Jewish women.
Shreeya Patel, Rosa Legood, D Gareth Evans, Clare Turnbull, Antonis C Antoniou, Usha Menon, Ian Jacobs, Ranjit Manchanda
Mar 09, 2018
BACKGROUND: Population-based BRCA1/BRCA2 founder-mutation testing has been demonstrated as cost effective compared with family history based testing in Ashkenazi Jewish women. However, only 1 of the 3 Ashkenazi Jewish...
BRCA Sephardi Jewish cost effectiveness population testing Adult Cost-Benefit Analysis Female Genes BRCA1 Genetic Testing Hereditary Breast and Ovarian Cancer Syndrome Heterozygote Hormone Replacement Therapy Humans Jews Life Expectancy Magnetic Resonance Imaging Mammography Markov Chains Middle Aged Mutation Ovariectomy Prophylactic Mastectomy Prophylactic Surgical Procedures Quality-Adjusted Life Years United Kingdom United States
Global, regional, and national burden of Alzheimer's disease and other dementias, 1990-2016
GBD 2016 Dementia Collaborators
Feb 08, 2019
BACKGROUND: The number of individuals living with dementia is increasing, negatively affecting families, communities, and health-care systems around the world. A successful response to these challenges requires an accurate...
Cost-effectiveness of 5 fraction and partial breast radiotherapy for early breast cancer in the UK
David Glynn, Judith Bliss, Adrian Murray Brunt, Charlotte E Coles, Duncan Wheatley, Joanne S Haviland, Anna M Kirby, Francesco Longo, Rita Faria, John R Yarnold, Susan Griffin
Jan 06, 2023
PURPOSE: We estimated the cost-effectiveness of 4 radiotherapy modalities to treat early breast cancer in the UK. In a subgroup of patients eligible for all modalities, we compared whole-breast (WB) and partial breast (PB)...
Cost-utility analysis of community occupational therapy in dementia (COTiD-UK) versus usual care
Elena Pizzo, Jennifer Wenborn, Jane Burgess, Jacqueline Mundy, Martin Orrell, Michael King, Rumana Omar, Stephen Morris
Mar 14, 2022
BACKGROUND: A community-based occupational therapy intervention for people with mild to moderate dementia and their family carers: the Community Occupational Therapy in Dementia-UK version (COTiD-UK); and Treatment as usual...
Multiple Interventions for Diabetic Foot Ulcer Treatment Trial (MIDFUT)
Sarah Brown, Jane Nixon, Myka Ransom, Rachael Gilberts, Nikki Dewhirst, Elizabeth McGinnis, Roberta Longo, Frances Game, Chris Bojke, Paul Chadwick, Akila Chandrasekar, Ian Chetter, Howard Collier, Catherine Fernandez, Shervanthi Homer-Vanniasinkam, Edward Jude, Richard Leigh, Richard Lomas, Peter Vowden, James Wason, Linda Sharples, David Russell
May 11, 2020
INTRODUCTION: Diabetes affects more than 425 million people worldwide with a lifetime risk of diabetic foot ulcer (DFU) of up to 25%. Management includes wound debridement, wound dressings, offloading, treatment of infection and...
Clinical Trials DIABETES & ENDOCRINOLOGY Diabetic Foot statistics & research methods wound management Acellular Dermis Adult Clinical Trials Phase II as Topic Clinical Trials Phase III as Topic Cost-Benefit Analysis Debridement Diabetes mellitus Diabetic Foot Humans Multicenter Studies as Topic Negative-Pressure Wound Therapy Quality of life Quality-Adjusted Life Years Randomized Controlled Trials as Topic Skin Transplantation Wound Healing
Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015
BACKGROUND: Non-fatal outcomes of disease and injury increasingly detract from the ability of the world's population to live in full health, a trend largely attributable to an epidemiological transition in many countries from...
Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017
GBD 2017 Risk Factor Collaborators
Sep 18, 2019
BACKGROUND: The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 comparative risk assessment (CRA) is a comprehensive approach to risk factor quantification that offers a useful tool for synthesising...
Adolescent Adult Age Distribution Aged Aged 80 and over Child Child Preschool Disabled Persons Environmental Exposure Female Global Burden of Disease Global Health Health Risk Behaviors Humans Infant Infant Newborn Life Expectancy Male Metabolic Diseases Middle Aged Occupational Diseases occupational exposure Quality-Adjusted Life Years Risk Assessment Sex Distribution Socioeconomic Factors Young Adult
Discrete Event Simulation for Decision Modeling in Health Care
Matthew J Glover, Edmund Jones, Katya L Masconi, Michael J Sweeting, Simon G Thompson, SWAN collaborators, SWAN Collaborative Group
May 24, 2018
Markov models are often used to evaluate the cost-effectiveness of new healthcare interventions but they are sometimes not flexible enough to allow accurate modeling or investigation of alternative scenarios and policies. A...
Cost-effectiveness of personal tailored risk information and taster sessions to increase the uptake of the NHS stop smoking services
Qi Wu, Hazel Gilbert, Irwin Nazareth, Stephen Sutton, Richard Morris, Irene Petersen, Simon Galton, Steve Parrott
May 30, 2018
AIMS: To assess the cost-effectiveness of a two-component intervention designed to increase attendance at the NHS Stop Smoking Services (SSSs) in England. DESIGN: Cost-effectiveness analysis alongside a randomized controlled...
cost-effectiveness personal tailored risk information Randomized controlled trial Smoking Cessation stop smoking services uptake of service Cost-Benefit Analysis England general practitioners Humans Patient Education as Topic Patient Selection Quality-Adjusted Life Years risk Smoking Smoking Cessation State Medicine United Kingdom
Are brief interventions to increase physical activity cost-effective? A systematic review.
Vijay GC, Edward Cf Wilson, Marc Suhrcke, Wendy Hardeman, Stephen Sutton, VBI Programme Team
Jul 28, 2015
Understanding cost-utility analysis studies in the trauma and orthopaedic surgery literature.
Cost-utility analysis (CUA) studies are becoming increasingly important due to the need to reduce healthcare spending, especially in the field of trauma and orthopaedics.There is an increasing need for trauma and orthopaedic...
The clinical and cost effectiveness of a Breathlessness Intervention Service for patients with advanced non-malignant disease and their informal carers
Morag C Farquhar, A Toby Prevost, Paul McCrone, Barbara Brafman-Price, Allison Bentley, Irene J Higginson, Chris J Todd, Sara Booth
Mar 24, 2016
advanced disease breathlessness Chronic obstructive pulmonary disease complex intervention mixed methods Non-malignant disease Palliative Care randomised controlled trial Aged Aged 80 and over Caregivers Combined Modality Therapy Cost-Benefit Analysis Dyspnea England Female Health Care Costs Humans Lung Male Middle Aged Palliative Care Patient Care Team Pulmonary Disease Chronic Obstructive qualitative research Quality of life Quality-Adjusted Life Years Respiration Single-Blind Method Surveys and Questionnaires Time Factors Treatment Outcome
Estimating the health impact of vaccination against ten pathogens in 98 low-income and middle-income countries from 2000 to 2030
Xiang Li, Christinah Mukandavire, Zulma M Cucunubá, Susy Echeverria Londono, Kaja Abbas, Hannah E Clapham, Mark Jit, Hope L Johnson, Timos Papadopoulos, Emilia Vynnycky, Marc Brisson, Emily D Carter, Andrew Clark, Margaret J de Villiers, Kirsten Eilertson, Matthew J Ferrari, Ivane Gamkrelidze, Katy AM Gaythorpe, Nicholas C Grassly, Timothy B Hallett, Wes Hinsley, Michael L Jackson, Kévin Jean, Andromachi Karachaliou, Petra Klepac, Justin Lessler, Xi Li, Sean M Moore, Shevanthi Nayagam, Duy Manh Nguyen, Homie Razavi, Devin Razavi-Shearer, Stephen Resch, Colin Sanderson, Steven Sweet, Stephen Sy, Yvonne Tam, Hira Tanvir, Quan Minh Tran, Caroline L Trotter, Shaun Truelove, Kevin van Zandvoort, Stéphane Verguet, Neff Walker, Amy Winter, Kim Woodruff, Neil M Ferguson, Tini Garske, Vaccine Impact Modelling Consortium
Feb 01, 2021
BACKGROUND: The past two decades have seen expansion of childhood vaccination programmes in low-income and middle-income countries (LMICs). We quantify the health impact of these programmes by estimating the deaths and...
Trends in type 2 diabetes mellitus disease burden in European Union countries between 1990 and 2019.
Richard Goodall, Andrew Alazawi, Will Hughes, Vassiliki Bravis, Justin D Salciccioli, Dominic C Marshall, Conor Crowley, Joseph Shalhoub
Aug 29, 2021
This observational study aimed to assess trends in type 2 diabetes mellitus (T2DM) disease burden in European Union countries for the years 1990-2019. Sex specific T2DM age-standardised prevalence (ASPRs), mortality (ASMRs) and...
Epidemiological impact and cost-effectiveness of universal vaccination with Bexsero(®) to reduce meningococcal group B disease in Germany.
Hannah Christensen, Tom Irving, Judith Koch, Caroline L Trotter, Bernhard Ultsch, Felix Weidemann, Ole Wichmann, Wiebke Hellenbrand
Apr 21, 2016
Changes in health in the countries of the UK and 150 English Local Authority areas 1990-2016
Nicholas Steel, John A Ford, John N Newton, Adrian CJ Davis, Theo Vos, Mohsen Naghavi, Scott Glenn, Andrew Hughes, Alice M Dalton, Diane Stockton, Ciaran Humphreys, Mary Dallat, Jürgen Schmidt, Julian Flowers, Sebastian Fox, Ibrahim Abubakar, Robert W Aldridge, Allan Baker, Carol Brayne, Traolach Brugha, Simon Capewell, Josip Car, Cyrus Cooper, Majid Ezzati, Justine Fitzpatrick, Felix Greaves, Roderick Hay, Simon Hay, Frank Kee, Heidi J Larson, Ronan A Lyons, Azeem Majeed, Martin McKee, Salman Rawaf, Harry Rutter, Sonia Saxena, Aziz Sheikh, Liam Smeeth, Russell M Viner, Stein Emil Vollset, Hywel C Williams, Charles Wolfe, Anthony Woolf, Christopher JL Murray
Feb 07, 2019
BACKGROUND: Previous studies have reported national and regional Global Burden of Disease (GBD) estimates for the UK. Because of substantial variation in health within the UK, action to improve it requires comparable estimates...
Adolescent Adult Aged Aged 80 and over Cause of Death Child Child Preschool Disability Evaluation Disabled Persons Female Global Burden of Disease health status Health Status Disparities Humans Infant Infant Newborn Life Expectancy Male Middle Aged Mortality Poverty Areas Quality-Adjusted Life Years Risk Factors Socioeconomic Factors United Kingdom Young Adult
Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017
GBD 2017 DALYs and HALE Collaborators
Feb 08, 2019
BACKGROUND: How long one lives, how many years of life are spent in good and poor health, and how the population's state of health and leading causes of disability change over time all have implications for policy, planning, and...
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