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Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases.
Adriana I Iglesias, Aniket Mishra, Veronique Vitart, Yelena Bykhovskaya, René Höhn, Henriët Springelkamp, Gabriel Cuellar-Partida, Puya Gharahkhani, Jessica N Cooke Bailey, Colin E Willoughby, Xiaohui Li, Seyhan Yazar, Abhishek Nag, Anthony P Khawaja, Ozren Polašek, David Siscovick, Paul Mitchell, Yih Chung Tham, Jonathan L Haines, Lisa S Kearns, Caroline Hayward, Yuan Shi, Elisabeth M van Leeuwen, Kent D Taylor, Blue Mountains Eye Study—GWAS group, Pieter Bonnemaijer, Jerome I Rotter, Nicholas G Martin, Tanja Zeller, Richard A Mills, Emmanuelle Souzeau, Sandra E Staffieri, Jost B Jonas, Irene Schmidtmann, Thibaud Boutin, Jae H Kang, Sionne EM Lucas, Tien Yin Wong, Manfred E Beutel, James F Wilson, NEIGHBORHOOD Consortium, Wellcome Trust Case Control Consortium 2 (WTCCC2), André G Uitterlinden, Eranga N Vithana, Paul J Foster, Pirro G Hysi, Alex W Hewitt, Chiea Chuen Khor, Louis R Pasquale, Grant W Montgomery, Caroline CW Klaver, Tin Aung, Norbert Pfeiffer, David A Mackey, Christopher J Hammond, Ching-Yu Cheng, Jamie E Craig, Yaron S Rabinowitz, Janey L Wiggs, Kathryn P Burdon, Cornelia M van Duijn, Stuart MacGregor
Sep 05, 2018
Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide association meta-analysis of CCT and identify 19 novel regions. In...
ADAMTS Proteins Asian People Cornea Corneal Diseases Corneal Dystrophies Hereditary Decorin Ehlers-Danlos Syndrome Eye Diseases Hereditary Fibrillin-1 Gene Expression Genome Human Genome-Wide Association Study Glaucoma Open-Angle Humans Keratoconus Loeys-Dietz Syndrome Lumican Marfan Syndrome Mendelian Randomization Analysis Myopia Polymorphism Single Nucleotide Proteoglycans Quantitative Trait Loci Quantitative Trait Heritable Transforming Growth Factor beta2 White People
Economic and hydraulic divergences underpin ecological differentiation in the Bromeliaceae.
Leaf economic and hydraulic theories have rarely been applied to the ecological differentiation of speciose herbaceous plant radiations. The role of character trait divergences and network reorganization in the differentiation...
The overlap between autistic spectrum conditions and borderline personality disorder
Robert B Dudas, Chris Lovejoy, Sarah Cassidy, Carrie Allison, Paula Smith, Simon Baron-Cohen
Nov 22, 2017
Prioritizing the Role of Major Lipoproteins and Subfractions as Risk Factors for Peripheral Artery Disease.
Michael G Levin, Verena Zuber, Venexia M Walker, Derek Klarin, Julie Lynch, Rainer Malik, Aaron W Aday, Leonardo Bottolo, Aruna D Pradhan, Martin Dichgans, Kyong-Mi Chang, Daniel J Rader, Philip S Tsao, Benjamin F Voight, Dipender Gill, Stephen Burgess, Scott M Damrauer
Jul 05, 2021
BACKGROUND: Lipoprotein-related traits have been consistently identified as risk factors for atherosclerotic cardiovascular disease, largely on the basis of studies of coronary artery disease (CAD). The relative contributions of...
Atherosclerosis Coronary Artery Disease Genomics Lipoproteins Peripheral Arterial Disease Alleles Apolipoproteins Biomarkers Disease Susceptibility Gene Expression Profiling Genetic Predisposition to Disease Genome-Wide Association Study Humans Lipid Metabolism Peripheral Arterial Disease Public Health Surveillance Quantitative Trait Heritable Risk Assessment Risk Factors Transcriptome United Kingdom
Events in Early Life are Associated with Female Reproductive Ageing
Katherine S Ruth, John RB Perry, William E Henley, David Melzer, Michael N Weedon, Anna Murray
Apr 22, 2016
Genome-wide associations for birth weight and correlations with adult disease
M Horikoshi, RN Beaumont, FR Day, NM Warrington, MN Kooijman, J Fernandez-Tajes, B Feenstra, NR van Zuydam, KJ Gaulton, N Grarup, JP Bradfield, DP Strachan, R Li-Gao, TS Ahluwalia, E Kreiner, R Rueedi, L-P Lyytikäinen, DL Cousminer, Y Wu, E Thiering, CA Wang, CT Have, J-J Hottenga, N Vilor-Tejedor, PK Joshi, ETH Boh, I Ntalla, N Pitkänen, A Mahajan, EM van Leeuwen, R Joro, V Lagou, M Nodzenski, LA Diver, KT Zondervan, M Bustamante, P Marques-Vidal, JM Mercader, AJ Bennett, N Rahmioglu, DR Nyholt, RCW Ma, CHT Tam, WH Tam, CHARGE Consortium Hematology Working Group, SK Ganesh, FJA van Rooij, SE Jones, P-R Loh, KS Ruth, MA Tuke, J Tyrrell, AR Wood, H Yaghootkar, DM Scholtens, L Paternoster, I Prokopenko, P Kovacs, M Atalay, SM Willems, K Panoutsopoulou, X Wang, L Carstensen, F Geller, KE Schraut, M Murcia, CEM van Beijsterveldt, G Willemsen, EVR Appel, CE Fonvig, C Trier, CMT Tiesler, M Standl, Z Kutalik, S Bonàs-Guarch, DM Hougaard, F Sánchez, D Torrents, J Waage, MV Hollegaard, HG de Haan, FR Rosendaal, C Medina-Gomez, SM Ring, G Hemani, G McMahon, NR Robertson, CJ Groves, C Langenberg, J Luan, RA Scott, JH Zhao, FD Mentch, SM MacKenzie, RM Reynolds, Early Growth Genetics (EGG) Consortium, WL Lowe, A Tönjes, M Stumvoll, V Lindi, TA Lakka, CM van Duijn, W Kiess, A Körner, TIA Sørensen, H Niinikoski, K Pahkala, OT Raitakari, E Zeggini, GV Dedoussis, Y-Y Teo, S-M Saw, M Melbye, H Campbell, JF Wilson, M Vrijheid, EJCN de Geus, DI Boomsma, HN Kadarmideen, J-C Holm, T Hansen, S Sebert, AT Hattersley, LJ Beilin, JP Newnham, CE Pennell, J Heinrich, LS Adair, JB Borja, KL Mohlke, JG Eriksson, E Widén, M Kähönen, JS Viikari, T Lehtimäki, P Vollenweider, K Bønnelykke, H Bisgaard, DO Mook-Kanamori, A Hofman, F Rivadeneira, AG Uitterlinden, C Pisinger, O Pedersen, C Power, E Hyppönen, NJ Wareham, H Hakonarson, E Davies, BR Walker, VWV Jaddoe, M-R Järvelin, SFA Grant, AA Vaag, DA Lawlor, TM Frayling, GD Smith, AP Morris, KK Ong, JF Felix, NJ Timpson, JRB Perry, DM Evans, MI McCarthy, RM Freathy
Dec 01, 2016
Integration of disease association and eQTL data using a Bayesian colocalisation approach highlights six candidate causal genes in immune-mediated diseases.
Suspiciousness in young minds
Han-Yu Zhou, Keri Ka-Yee Wong, Li-Juan Shi, Xi-Long Cui, Yun Qian, Wen-Qing Jiang, Ya-Song Du, Simon SY Lui, Xue-Rong Luo, Zheng-Hui Yi, Eric FC Cheung, Anna R Docherty, Raymond CK Chan
Jun 06, 2018
BACKGROUND: We validated the Social Mistrust Scale (SMS) and utilized it to examine the structure, prevalence, and heritability of social mistrust in a large sample of Chinese children and adolescents. METHODS: In Study 1, a...
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.
Gail Davies, Max Lam, Sarah E Harris, Joey W Trampush, Michelle Luciano, W David Hill, Saskia P Hagenaars, Stuart J Ritchie, Riccardo E Marioni, Chloe Fawns-Ritchie, David Cm Liewald, Judith A Okely, Ari V Ahola-Olli, Catriona LK Barnes, Lars Bertram, Joshua C Bis, Katherine E Burdick, Andrea Christoforou, Pamela DeRosse, Srdjan Djurovic, Thomas Espeseth, Stella Giakoumaki, Sudheer Giddaluru, Daniel E Gustavson, Caroline Hayward, Edith Hofer, M Arfan Ikram, Robert Karlsson, Emma Knowles, Jari Lahti, Markus Leber, Shuo Li, Karen A Mather, Ingrid Melle, Derek Morris, Christopher Oldmeadow, Teemu Palviainen, Antony Payton, Raha Pazoki, Katja Petrovic, Chandra A Reynolds, Muralidharan Sargurupremraj, Markus Scholz, Jennifer A Smith, Albert V Smith, Natalie Terzikhan, Anbupalam Thalamuthu, Stella Trompet, Sven J van der Lee, Erin B Ware, B Gwen Windham, Margaret J Wright, Jingyun Yang, Jin Yu, David Ames, Najaf Amin, Philippe Amouyel, Ole A Andreassen, Nicola J Armstrong, Amelia A Assareh, John R Attia, Deborah Attix, Dimitrios Avramopoulos, David A Bennett, Anne C Böhmer, Patricia A Boyle, Henry Brodaty, Harry Campbell, Tyrone D Cannon, Elizabeth T Cirulli, Eliza Congdon, Emily Drabant Conley, Janie Corley, Simon R Cox, Anders M Dale, Abbas Dehghan, Danielle Dick, Dwight Dickinson, Johan G Eriksson, Evangelos Evangelou, Jessica D Faul, Ian Ford, Nelson A Freimer, He Gao, Ina Giegling, Nathan A Gillespie, Scott D Gordon, Rebecca F Gottesman, Michael E Griswold, Vilmundur Gudnason, Tamara B Harris, Annette M Hartmann, Alex Hatzimanolis, Gerardo Heiss, Elizabeth G Holliday, Peter K Joshi, Mika Kähönen, Sharon LR Kardia, Ida Karlsson, Luca Kleineidam, David S Knopman, Nicole A Kochan, Bettina Konte, John B Kwok, Stephanie Le Hellard, Teresa Lee, Terho Lehtimäki, Shu-Chen Li, Tian Liu, Marisa Koini, Edythe London, Will T Longstreth, Oscar L Lopez, Anu Loukola, Tobias Luck, Astri J Lundervold, Anders Lundquist, Leo-Pekka Lyytikäinen, Nicholas G Martin, Grant W Montgomery, Alison D Murray, Anna C Need, Raymond Noordam, Lars Nyberg, William Ollier, Goran Papenberg, Alison Pattie, Ozren Polasek, Russell A Poldrack, Bruce M Psaty, Simone Reppermund, Steffi G Riedel-Heller, Richard J Rose, Jerome I Rotter, Panos Roussos, Suvi P Rovio, Yasaman Saba, Fred W Sabb, Perminder S Sachdev, Claudia L Satizabal, Matthias Schmid, Rodney J Scott, Matthew A Scult, Jeannette Simino, P Eline Slagboom, Nikolaos Smyrnis, Aïcha Soumaré, Nikos C Stefanis, David J Stott, Richard E Straub, Kjetil Sundet, Adele M Taylor, Kent D Taylor, Ioanna Tzoulaki, Christophe Tzourio, André Uitterlinden, Veronique Vitart, Aristotle N Voineskos, Jaakko Kaprio, Michael Wagner, Holger Wagner, Leonie Weinhold, K Hoyan Wen, Elisabeth Widen, Qiong Yang, Wei Zhao, Hieab HH Adams, Dan E Arking, Robert M Bilder, Panos Bitsios, Eric Boerwinkle, Ornit Chiba-Falek, Aiden Corvin, Philip L De Jager, Stéphanie Debette, Gary Donohoe, Paul Elliott, Annette L Fitzpatrick, Michael Gill, David C Glahn, Sara Hägg, Narelle K Hansell, Ahmad R Hariri, M Kamran Ikram, J Wouter Jukema, Eero Vuoksimaa, Matthew C Keller, William S Kremen, Lenore Launer, Ulman Lindenberger, Aarno Palotie, Nancy L Pedersen, Neil Pendleton, David J Porteous, Katri Räikkönen, Olli T Raitakari, Alfredo Ramirez, Ivar Reinvang, Igor Rudan, Dan Rujescu, Reinhold Schmidt, Helena Schmidt, Peter W Schofield, Peter R Schofield, John M Starr, Vidar M Steen, Julian N Trollor, Steven T Turner, Cornelia M van Duijn, Arno Villringer, Daniel R Weinberger, David R Weir, James F Wilson, Anil Malhotra, Andrew M McIntosh, Catharine R Gale, Sudha Seshadri, Thomas H Mosley, Jan Bressler, Todd Lencz, Ian J Deary
Sep 24, 2018
General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total...
The opposite end of the attention deficit hyperactivity disorder (ADHD) continuum
Corina U. Greven, Andrew Merwood, Jolanda M J van der Meer, Claire M. A. Haworth, Nanda Rommelse, Jan K. Buitelaar
Apr 01, 2016
Background: Although attention deficit hyperactivity disorder (ADHD) is thought to reflect a continuously distributed quantitative trait, it is assessed through binary diagnosis or skewed measures biased towards its high...
Computational analysis of GAL pathway pinpoints mechanisms underlying natural variation.
Quantitative traits are measurable phenotypes that show continuous variation over a wide phenotypic range. Enormous effort has recently been put into determining the genetic influences on a variety of quantitative traits with...
Computational Biology Computer Simulation Galactose Gene Expression Regulation Fungal genetic variation Metabolic Networks and Pathways Models Biological Monosaccharide Transport Proteins Mutation Phenotype Quantitative Trait Heritable Repressor Proteins Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Transcription Factors
A Bayesian Approach to the Overlap Analysis of Epidemiologically Linked Traits.
Jennifer L Asimit, Kalliope Panoutsopoulou, Eleanor Wheeler, Sonja I Berndt, the arcOGEN consortium GIANT consortium, Heather J Cordell, Andrew P Morris, Eleftheria Zeggini, Inês Barroso
Aug 15, 2018
Diseases often cooccur in individuals more often than expected by chance, and may be explained by shared underlying genetic etiology. A common approach to genetic overlap analyses is to use summary genome-wide association study...
Bayes’ factor P-value obesity Osteoarthritis overlap analysis threshold calibration Bayes Theorem Body Mass Index Computer Simulation Data Interpretation Statistical Genome-Wide Association Study Humans Models Genetic obesity Osteoarthritis Phenotype Polymorphism Single Nucleotide Probability Quantitative Trait Heritable Sample Size
Quantitative trait loci and transcriptome signatures associated with avian heritable resistance to Campylobacter.
Androniki Psifidi, Andreas Kranis, Lisa M Rothwell, Abi Bremner, Kay Russell, Diego Robledo, Stephen J Bush, Mark Fife, Paul M Hocking, Georgios Banos, David A Hume, Jim Kaufman, Richard A Bailey, Santiago Avendano, Kellie A Watson, Pete Kaiser, Mark P Stevens
Jan 12, 2021
Impulsivity is a heritable trait in rodents and associated with a novel quantitative trait locus on chromosome 1.
Bianca Jupp, Silvia Pitzoi, Enrico Petretto, Adam C Mar, Yolanda Pena Oliver, Emily R Jordan, Stephanie Taylor, Santosh S Atanur, Prashant K Srivastava, Kathrin Saar, Norbert Hubner, Wolfgang H Sommer, Oliver Staehlin, Rainer Spanagel, Emma S Robinson, Gunter Schumann, Margarita Moreno, Barry J Everitt, Trevor W Robbins, Timothy J Aitman, Jeffrey W Dalley
Apr 02, 2020
FBXO7 sensitivity of phenotypic traits elucidated by a hypomorphic allele.
Carmen Ballesteros Reviriego, Simon Clare, Mark J Arends, Emma L Cambridge, Agnieszka Swiatkowska, Susana Caetano, Bushra Abu-Helil, Leanne Kane, Katherine Harcourt, David A Goulding, Diane Gleeson, Edward Ryder, Brendan Doe, Jacqueline K White, Louise van der Weyden, Gordon Dougan, David J Adams, Anneliese O Speak
Mar 19, 2019
FBXO7 encodes an F box containing protein that interacts with multiple partners to facilitate numerous cellular processes and has a canonical role as part of an SCF E3 ubiquitin ligase complex. Mutation of FBXO7 is responsible...
A two-stage inter-rater approach for enrichment testing of variants associated with multiple traits.
Shared genetic aetiology may explain the co-occurrence of diseases in individuals more often than expected by chance. On identifying associated variants shared between two traits, one objective is to determine whether such...
Multi-trait genome-wide association study identifies new loci associated with optic disc parameters.
Pieter WM Bonnemaijer, Elisabeth M van Leeuwen, Adriana I Iglesias, Puya Gharahkhani, Veronique Vitart, Anthony P Khawaja, Mark Simcoe, René Höhn, Angela J Cree, Rob P Igo, International Glaucoma Genetics Consortium, NEIGHBORHOOD Consortium, UK Biobank Eye and Vision Consortium, Aslihan Gerhold-Ay, Stefan Nickels, James F Wilson, Caroline Hayward, Thibaud S Boutin, Ozren Polašek, Tin Aung, Chiea Chuen Khor, Najaf Amin, Andrew J Lotery, Janey L Wiggs, Ching-Yu Cheng, Pirro G Hysi, Christopher J Hammond, Alberta AHJ Thiadens, Stuart MacGregor, Caroline CW Klaver, Cornelia M van Duijn
Nov 26, 2020
genome-wide association studies Optic Nerve Diseases Case-Control Studies Computational Biology Gene Expression Profiling Genetic Association Studies Genetic Predisposition to Disease Genome-Wide Association Study Glaucoma Humans Molecular Sequence Annotation Optic Disk Optic Nerve Diseases Polymorphism Single Nucleotide Quantitative Trait Loci Quantitative Trait Heritable Signal Transduction
A multivariate analysis of genetic constraints to life history evolution in a wild population of red deer.
Craig A Walling, Michael B Morrissey, Katharina Foerster, Tim H Clutton-Brock, Josephine M Pemberton, Loeske EB Kruuk
May 03, 2021
Evolutionary theory predicts that genetic constraints should be widespread, but empirical support for their existence is surprisingly rare. Commonly applied univariate and bivariate approaches to detecting genetic constraints...
Haplotype tagging reveals parallel formation of hybrid races in two butterfly species.
Joana I Meier, Patricio A Salazar, Marek Kučka, Robert William Davies, Andreea Dréau, Ismael Aldás, Olivia Box Power, Nicola J Nadeau, Jon R Bridle, Campbell Rolian, Nicholas H Barton, W Owen McMillan, Chris D Jiggins, Yingguang Frank Chan
Jul 02, 2021
Genetic variation segregates as linked sets of variants or haplotypes. Haplotypes and linkage are central to genetics and underpin virtually all genetic and selection analysis. Yet, genomic data often omit haplotype information...
Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits.
Arthur Gilly, Daniel Suveges, Karoline Kuchenbaecker, Martin Pollard, Lorraine Southam, Konstantinos Hatzikotoulas, Aliki-Eleni Farmaki, Thea Bjornland, Ryan Waples, Emil VR Appel, Elisabetta Casalone, Giorgio Melloni, Britt Kilian, Nigel W Rayner, Ioanna Ntalla, Kousik Kundu, Klaudia Walter, John Danesh, Adam Butterworth, Inês Barroso, Emmanouil Tsafantakis, George Dedoussis, Ida Moltke, Eleftheria Zeggini
Feb 07, 2019
The role of rare variants in complex traits remains uncharted. Here, we conduct deep whole genome sequencing of 1457 individuals from an isolated population, and test for rare variant burdens across six cardiometabolic traits....
Genome-wide association study identifies 48 common genetic variants associated with handedness.
Gabriel Cuellar-Partida, Joyce Y Tung, Nicholas Eriksson, Eva Albrecht, Fazil Aliev, Ole A Andreassen, Inês Barroso, Jacques S Beckmann, Marco P Boks, Dorret I Boomsma, Heather A Boyd, Monique MB Breteler, Harry Campbell, Daniel I Chasman, Lynn F Cherkas, Gail Davies, Eco JC de Geus, Ian J Deary, Panos Deloukas, Danielle M Dick, David L Duffy, Johan G Eriksson, Tõnu Esko, Bjarke Feenstra, Frank Geller, Christian Gieger, Ina Giegling, Scott D Gordon, Jiali Han, Thomas F Hansen, Annette M Hartmann, Caroline Hayward, Kauko Heikkilä, Andrew A Hicks, Joel N Hirschhorn, Jouke-Jan Hottenga, Jennifer E Huffman, Liang-Dar Hwang, M Arfan Ikram, Jaakko Kaprio, John P Kemp, Kay-Tee Khaw, Norman Klopp, Bettina Konte, Zoltan Kutalik, Jari Lahti, Xin Li, Ruth JF Loos, Michelle Luciano, Sigurdur H Magnusson, Massimo Mangino, Pedro Marques-Vidal, Nicholas G Martin, Wendy L McArdle, Mark I McCarthy, Carolina Medina-Gomez, Mads Melbye, Scott A Melville, Andres Metspalu, Lili Milani, Vincent Mooser, Mari Nelis, Dale R Nyholt, Kevin S O'Connell, Roel A Ophoff, Cameron Palmer, Aarno Palotie, Teemu Palviainen, Guillaume Pare, Lavinia Paternoster, Leena Peltonen, Brenda WJH Penninx, Ozren Polasek, Peter P Pramstaller, Inga Prokopenko, Katri Raikkonen, Samuli Ripatti, Fernando Rivadeneira, Igor Rudan, Dan Rujescu, Johannes H Smit, George Davey Smith, Jordan W Smoller, Nicole Soranzo, Tim D Spector, Beate St Pourcain, John M Starr, Hreinn Stefánsson, Stacy Steinberg, Maris Teder-Laving, Gudmar Thorleifsson, Kári Stefánsson, Nicholas J Timpson, André G Uitterlinden, Cornelia M van Duijn, Frank JA van Rooij, Jaqueline M Vink, Peter Vollenweider, Eero Vuoksimaa, Gérard Waeber, Nicholas J Wareham, Nicole Warrington, Dawn Waterworth, Thomas Werge, H-Erich Wichmann, Elisabeth Widen, Gonneke Willemsen, Alan F Wright, Margaret J Wright, Mousheng Xu, Jing Hua Zhao, Peter Kraft, David A Hinds, Cecilia M Lindgren, Reedik Mägi, Benjamin M Neale, David M Evans, Sarah E Medland
Aug 19, 2020
Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International...
Genetic effects on promoter usage are highly context-specific and contribute to complex traits.
Kaur Alasoo, Julia Rodrigues, John Danesh, Daniel F Freitag, Dirk S Paul, Daniel J Gaffney
Feb 04, 2019
Genetic variants regulating RNA splicing and transcript usage have been implicated in both common and rare diseases. Although transcript usage quantitative trait loci (tuQTLs) have been mapped across multiple cell types and...
Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects.
Carolina Medina-Gomez, John P Kemp, Katerina Trajanoska, Jian'an Luan, Alessandra Chesi, Tarunveer S Ahluwalia, Dennis O Mook-Kanamori, Annelies Ham, Fernando P Hartwig, Daniel S Evans, Raimo Joro, Ivana Nedeljkovic, Hou-Feng Zheng, Kun Zhu, Mustafa Atalay, Ching-Ti Liu, Maria Nethander, Linda Broer, Gudmar Porleifsson, Benjamin H Mullin, Samuel K Handelman, Mike A Nalls, Leon E Jessen, Denise HM Heppe, J Brent Richards, Carol Wang, Bo Chawes, Katharina E Schraut, Najaf Amin, Nick Wareham, David Karasik, Nathalie van der Velde, M Arfan Ikram, Babette S Zemel, Yanhua Zhou, Christian J Carlsson, Yongmei Liu, Fiona E McGuigan, Cindy G Boer, Klaus Bønnelykke, Stuart H Ralston, John A Robbins, John P Walsh, M Carola Zillikens, Claudia Langenberg, Ruifang Li-Gao, Frances MK Williams, Tamara B Harris, Kristina Akesson, Rebecca D Jackson, Gunnar Sigurdsson, Martin den Heijer, Bram CJ van der Eerden, Jeroen van de Peppel, Timothy D Spector, Craig Pennell, Bernardo L Horta, Janine F Felix, Jing Hua Zhao, Scott G Wilson, Renée de Mutsert, Hans Bisgaard, Unnur Styrkársdóttir, Vincent W Jaddoe, Eric Orwoll, Timo A Lakka, Robert Scott, Struan FA Grant, Mattias Lorentzon, Cornelia M van Duijn, James F Wilson, Kari Stefansson, Bruce M Psaty, Douglas P Kiel, Claes Ohlsson, Evangelia Ntzani, Andre J van Wijnen, Vincenzo Forgetta, Mohsen Ghanbari, John G Logan, Graham R Williams, JH Duncan Bassett, Peter I Croucher, Evangelos Evangelou, Andre G Uitterlinden, Cheryl L Ackert-Bicknell, Jonathan H Tobias, David M Evans, Fernando Rivadeneira
Mar 14, 2018
Bone mineral density (BMD) assessed by DXA is used to evaluate bone health. In children, total body (TB) measurements are commonly used; in older individuals, BMD at the lumbar spine (LS) and femoral neck (FN) is used to...
BMD CREB3L1 ESR1 GWASs RANKL age-dependent effects Bone mineral density Fracture genetic correlation genome-wide association studies meta-regression total-body DXA Adolescent Age Factors Animals Bone Density Child Child Preschool Genetic Loci Genome-Wide Association Study Humans Infant Infant Newborn Mice Knockout Polymorphism Single Nucleotide Quantitative Trait Heritable Regression Analysis
Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function
Philipp S Wild, Janine F Felix, Arne Schillert, Alexander Teumer, Ming-Huei Chen, Maarten JG Leening, Uwe Völker, Vera Großmann, Jennifer A Brody, Marguerite R Irvin, Sanjiv J Shah, Setia Pramana, Wolfgang Lieb, Reinhold Schmidt, Alice V Stanton, Dörthe Malzahn, Albert Vernon Smith, Johan Sundström, Cosetta Minelli, Daniela Ruggiero, Leo-Pekka Lyytikäinen, Daniel Tiller, J Gustav Smith, Claire Monnereau, Marco R Di Tullio, Solomon K Musani, Alanna C Morrison, Tune H Pers, Michael Morley, Marcus E Kleber, Jayashri Aragam, Emelia J Benjamin, Joshua C Bis, Egbert Bisping, Ulrich Broeckel, Susan Cheng, Jaap W Deckers, Fabiola del Greco M, Frank Edelmann, Myriam Fornage, Lude Franke, Nele Friedrich, Tamara B Harris, Edith Hofer, Albert Hofman, Jie Huang, Alun D Hughes, Mika Kähönen, Knhi Investigators, Jochen Kruppa, Karl J Lackner, Lars Lannfelt, Rafael Laskowski, Lenore J Launer, Margrét Leosdottir, Honghuang Lin, Cecilia M Lindgren, Christina Loley, Calum A MacRae, Deborah Mascalzoni, Jamil Mayet, Daniel Medenwald, Andrew P Morris, Christian Müller, Martina Müller-Nurasyid, Stefania Nappo, Peter M Nilsson, Sebastian Nuding, Teresa Nutile, Annette Peters, Arne Pfeufer, Diana Pietzner, Peter P Pramstaller, Olli T Raitakari, Kenneth M Rice, Fernando Rivadeneira, Jerome I Rotter, Saku T Ruohonen, Ralph L Sacco, Tandaw E Samdarshi, Helena Schmidt, Andrew SP Sharp, Denis C Shields, Rossella Sorice, Nona Sotoodehnia, Bruno H Stricker, Praveen Surendran, Simon Thom, Anna M Töglhofer, André G Uitterlinden, Rolf Wachter, Henry Völzke, Andreas Ziegler, Thomas Münzel, Winfried März, Thomas P Cappola, Joel N Hirschhorn, Gary F Mitchell, Nicholas L Smith, Ervin R Fox, Nicole D Dueker, Vincent WV Jaddoe, Olle Melander, Martin Russ, Terho Lehtimäki, Marina Ciullo, Andrew A Hicks, Lars Lind, Vilmundur Gudnason, Burkert Pieske, Anthony J Barron, Robert Zweiker, Heribert Schunkert, Erik Ingelsson, Kiang Liu, Donna K Arnett, Bruce M Psaty, Stefan Blankenberg, Martin G Larson, Stephan B Felix, Oscar H Franco, Tanja Zeller, Ramachandran S Vasan, Marcus Dörr
Nov 27, 2017
Blood Eosinophil Count and Metabolic, Cardiac and Pulmonary Outcomes
Marzyeh Amini, Judith M Vonk, Ali Abbasi, Bram P Prins, Marcel Bruinenberg, Lude Franke, Pim van der Harst, Gerjan Navis, Gerard H Koppelman, Bruce Hr Wolffenbuttel, H Marike Boezen, Harold Snieder, Daniel I Chasman, Behrooz Z Alizadeh
Jun 04, 2018
Blood eosinophil count is associated with a variety of common complex outcomes in epidemiological observation. The aim of this study was to explore the causal association between determined blood eosinophil count and 20 common...
Mendelian randomization Cardiovascular Diseases complex diseases eosinophil count genetic risk score instrumental variable Metabolic Diseases pulmonary diseases Asthma Blood Glucose blood pressure Body Mass Index Cohort Studies Diabetes mellitus Type 2 Female Forced Expiratory Volume Genome-Wide Association Study Glycated Hemoglobin Humans Leukocyte Count Lipids Male Mendelian Randomization Analysis Metabolic Syndrome Pulmonary Disease Chronic Obstructive Quantitative Trait Heritable
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