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Structure of the NDH-2 - HQNO inhibited complex provides molecular insight into quinone-binding site inhibitors.
Jessica Petri, Yosuke Shimaki, Wanting Jiao, Hannah R Bridges, Euan R Russell, Emily J Parker, David Aragão, Gregory M Cook, Yoshio Nakatani
Sep 17, 2018
Type II NADH:quinone oxidoreductase (NDH-2) is a proposed drug-target of major pathogenic microorganisms such as Mycobacterium tuberculosis and Plasmodium falciparum. Many NDH-2 inhibitors have been identified, but rational drug...