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Hypoxia-induced SETX links replication stress with the unfolded protein response.
Shaliny Ramachandran, Tiffany S Ma, Jon Griffin, Natalie Ng, Iosifina P Foskolou, Ming-Shih Hwang, Pedro Victori, Wei-Chen Cheng, Francesca M Buffa, Katarzyna B Leszczynska, Sherif F El-Khamisy, Natalia Gromak, Ester M Hammond
Aug 20, 2021
Tumour hypoxia is associated with poor patient prognosis and therapy resistance. A unique transcriptional response is initiated by hypoxia which includes the rapid activation of numerous transcription factors in a background of...
Activating Transcription Factor 4 Cell Death Cell Hypoxia Cell Line Tumor Cell Survival Chromatin Immunoprecipitation DNA Damage DNA Helicases Gene Expression Regulation Humans Multifunctional Enzymes Nucleic Acid Synthesis Inhibitors Oxygen R-Loop Structures RNA Helicases RNA-seq Unfolded Protein Response Up-Regulation Zinostatin eIF-2 Kinase