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METTL15 introduces N4-methylcytidine into human mitochondrial 12S rRNA and is required for mitoribosome biogenesis.
Lindsey Van Haute, Alan G Hendrick, Aaron R D'Souza, Christopher A Powell, Pedro Rebelo-Guiomar, Michael E Harbour, ShuJing Ding, Ian M Fearnley, Byron Andrews, Michal Minczuk
Nov 26, 2019
A disease-linked lncRNA mutation in RNase MRP inhibits ribosome synthesis.
Nic Robertson, Vadim Shchepachev, David Wright, Tomasz W Turowski, Christos Spanos, Aleksandra Helwak, Rose Zamoyska, David Tollervey
Mar 07, 2022
RMRP encodes a non-coding RNA forming the core of the RNase MRP ribonucleoprotein complex. Mutations cause Cartilage Hair Hypoplasia (CHH), characterized by skeletal abnormalities and impaired T cell activation. Yeast RNase MRP...
Animals Base Sequence Cell Proliferation Cells Cultured Endoribonucleases FIBROBLASTS Hair Hirschsprung Disease Humans K562 Cells Mice Inbred C57BL Mice Knockout Mutation Osteochondrodysplasias Primary Immunodeficiency Diseases RNA Folding RNA Precursors RNA Long Noncoding RNA Ribosomal Ribosomes T-Lymphocytes
Targeting the Conserved Stem Loop 2 Motif in the SARS-CoV-2 Genome.
Valeria Lulla, Michal P Wandel, Katarzyna J Bandyra, Rachel Ulferts, Mary Wu, Tom Dendooven, Xiaofei Yang, Nicole Doyle, Stephanie Oerum, Rupert Beale, Sara M O'Rourke, Felix Randow, Helena J Maier, William Scott, Yiliang Ding, Andrew E Firth, Kotryna Bloznelyte, Ben F Luisi
Apr 26, 2021