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Structure of a bacterial ribonucleoprotein complex central to the control of cell envelope biogenesis
Md Saiful Islam, Steven W Hardwick, Laura Quell, Svetlana Durica‐Mitic, Dimitri Y Chirgadze, Boris Görke, Ben F Luisi
Dec 12, 2022
Biogenesis of the essential precursor of the bacterial cell envelope, glucosamine‐6‐phosphate (GlcN6P), is controlled by intricate post‐transcriptional networks mediated by GlmZ, a small regulatory RNA (sRNA). GlmZ stimulates...
A cooperative PNPase-Hfq-RNA carrier complex facilitates bacterial riboregulation.
Tom Dendooven, Dhriti Sinha, Alzbeta Roeselová, Todd A Cameron, Nicholas R De Lay, Ben F Luisi, Katarzyna J Bandyra
May 28, 2021
Polynucleotide phosphorylase (PNPase) is an ancient exoribonuclease conserved in the course of evolution and is found in species as diverse as bacteria and humans. Paradoxically, Escherichia coli PNPase can act not only as an...
Hfq RNA chaperone cryoEM Gene Silencing polynucleotide phosphorylase Ribonuclease ribonucleoprotein complex riboregulation small regulatory RNA Catalytic Domain Endoribonucleases Escherichia coli Escherichia coli Proteins Exoribonucleases Gene Expression Regulation Bacterial Host Factor 1 Protein Molecular Chaperones Polyribonucleotide Nucleotidyltransferase RNA Stability RNA Bacterial RNA Small Untranslated
Bacterial RNA chaperones and chaperone-like riboregulators
In all domains of life, RNA chaperones safeguard and guide the fate of the cellular RNA pool. RNA chaperones comprise structurally diverse proteins that ensure proper folding, stability, and ribonuclease resistance of RNA, and...
Human Norovirus NS3 Has RNA Helicase and Chaperoning Activities.
Teng-Feng Li, Myra Hosmillo, Hella Schwanke, Ting Shu, Zhaowei Wang, Lei Yin, Stephen Curry, Ian G Goodfellow, Xi Zhou
Mar 16, 2018
RNA-remodeling proteins, including RNA helicases and chaperones, act to remodel RNA structures and/or protein-RNA interactions and are required for all processes involving RNAs. Although many viruses encode RNA helicases and...
RNA chaperone RNA helicase Norovirus Amino Acid Sequence Cell Line Guanidine Humans Life Cycle Stages Molecular Chaperones Norovirus Nucleoside-Triphosphatase Protein Binding Protein Folding RNA Helicases RNA Viral Replicon Sequence Alignment Sequence Analysis Viral Nonstructural Proteins Virus Replication