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Long noncoding RNA repertoire and targeting by nuclear exosome, cytoplasmic exonuclease, and RNAi in fission yeast.
Sophie R Atkinson, Samuel Marguerat, Danny A Bitton, Maria Rodríguez-López, Charalampos Rallis, Jean-François Lemay, Cristina Cotobal, Michal Malecki, Pawel Smialowski, Juan Mata, Philipp Korber, François Bachand, Jürg Bähler
Oct 10, 2018
Long noncoding RNAs (lncRNAs), which are longer than 200 nucleotides but often unstable, contribute a substantial and diverse portion to pervasive noncoding transcriptomes. Most lncRNAs are poorly annotated and understood...
NMD pathway RNA degradation Schizosaccharomyces pombe Antisense RNA cytoplasmic exonuclease pervasive transcription Cell Nucleus Cytoplasm Exonucleases Exosomes Fungal Proteins Gene Expression Profiling Gene Expression Regulation Fungal Meiosis Molecular Sequence Annotation Mutation RNA Interference RNA Stability RNA Fungal RNA Long Noncoding Schizosaccharomyces Sequence Analysis RNA
Substrate Recognition and Autoinhibition in the Central Ribonuclease RNase E.
RNA degradation RNA processing RNA structure RNA-mediated regulation RNase E protein-RNA interactions protein-RNA structure small regulatory RNA Amino Acid Sequence Catalysis Endoribonucleases Escherichia coli Escherichia coli Proteins Gene Expression Regulation Bacterial Protein Subunits RNA RNA Bacterial Sequence Alignment Substrate Specificity
Exosomal Protein Deficiencies
Defects of RNA metabolism have been increasingly identified in various forms of inherited neurological diseases. Recently, abnormal RNA degradation due to mutations in human exosome subunit genes has been shown to cause complex...