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Most organisms rely on innate immune receptors to recognize conserved molecular structures from invading microbes. Two essential innate immune receptors, RIG-I and MDA5, detect viral double-stranded RNA in the cytoplasm. The...

RecA-like DEAD-box (DExD/H-box) RNA helicase amyloid-like aggregation caspase recruitment domain nucleic-acid sensor pathogen-associated molecular pattern prion-like switch Signal Transduction signalosome