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Results: 32
Recovery priorities in degenerative cervical myelopathy
Benjamin Davies, Oliver Mowforth, Iwan Sadler, Bizhan Aarabi, Brian Kwon, Shekar Kurpad, James S Harrop, Jefferson R Wilson, Robert Grossman, Michael G Fehlings, Mark Kotter
Aug 21, 2019
cervical degeneration disability disc herniation myelopathy ossification posterior longitudinal ligament patient and public involvement priority setting questionnaire recovery research wastage Spondylosis spondylotic Stenosis Cervical Vertebrae Cross-Sectional Studies Female Health Priorities Humans Male Middle Aged Recovery of Function Spinal Cord Diseases Surveys and Questionnaires Treatment Outcome
Changes in functional properties and 5-HT modulation above and below a spinal transection in lamprey.
A unified neurocomputational bilateral model of spoken language production in healthy participants and recovery in poststroke aphasia.
Understanding the processes underlying normal, impaired, and recovered language performance has been a long-standing goal for cognitive and clinical neuroscience. Many verbally described hypotheses about language lateralization...
Axonal plasticity underpins the functional recovery following surgical decompression in a rat model of cervical spondylotic myelopathy.
Rana S Dhillon, John Parker, Yasir A Syed, Steve Edgley, Adam Young, James W Fawcett, Nick D Jeffery, Robin Jm Franklin, Mark RN Kotter
Sep 26, 2016
Animals Apoptosis Axons Decompression Surgical Disease Models Animal Immunohistochemistry Male Motor Activity Neuroglia Neuronal Plasticity Random Allocation Rats Sprague-Dawley Recovery of Function Severity of Illness Index Spinal Cord Compression Spondylosis Synapses Synaptophysin Treatment Outcome
Time course of functional changes in locomotor and sensory systems after spinal cord lesions in lamprey.
Changes in motor and sensory properties occur either side of spinal cord lesion sites from lower vertebrates to humans. We have previously examined these changes in the lamprey, a model system for studying recovery after spinal...
Chondroitinase improves anatomical and functional outcomes after primate spinal cord injury.
Ephron S Rosenzweig, Ernesto A Salegio, Justine J Liang, Janet L Weber, Chase A Weinholtz, John H Brock, Rod Moseanko, Stephanie Hawbecker, Roger Pender, Christina L Cruzen, Jennifer F Iaci, Anthony O Caggiano, Andrew R Blight, Barbara Haenzi, J Russell Huie, Leif A Havton, Yvette S Nout-Lomas, James W Fawcett, Adam R Ferguson, Michael S Beattie, Jacqueline C Bresnahan, Mark H Tuszynski
Sep 05, 2019
Changes in descending motor pathway connectivity after corticospinal tract lesion in macaque monkey.
Damage to the corticospinal tract is a leading cause of motor disability, for example in stroke or spinal cord injury. Some function usually recovers, but whether plasticity of undamaged ipsilaterally descending corticospinal...
A systematic review of living kidney donor enhanced recovery after surgery.
Matthew HV Byrne, Ahmed Mehmood, Dominic M Summers, Sarah A Hosgood, Michael L Nicholson
Jun 17, 2021
Enhanced recovery after surgery (ERAS) reduces complications and shortens hospital stay without increasing readmission or mortality. However, its role in living donor nephrectomy (LDN) has not yet been defined. Medline, Embase...
Early Levels of Glial Fibrillary Acidic Protein and Neurofilament Light Protein in Predicting the Outcome of Mild Traumatic Brain Injury.
Iftakher Hossain, Mehrbod Mohammadian, Riikka SK Takala, Olli Tenovuo, Linnéa Lagerstedt, Henna Ala-Seppälä, Janek Frantzén, Mark van Gils, Peter Hutchinson, Ari J Katila, Henna-Riikka Maanpää, David K Menon, Virginia F Newcombe, Jussi Tallus, Kevin Hrusovsky, David H Wilson, Kaj Blennow, Jean-Charles Sanchez, Henrik Zetterberg, Jussi P Posti
Jan 09, 2019
The purpose of this study was to correlate the early levels of glial fibrillary acidic protein (GFAP) and neurofilament light protein (NF-L) with outcome in patients with mild traumatic brain injury (mTBI). A total of 107...
Hemispheric contributions to language reorganisation
Bettina Mohr, Lucy J MacGregor, Stephanie Difrancesco, Karen Harrington, Friedemann Pulvermüller, Yury Shtyrov
Nov 21, 2019
Previous studies have demonstrated that efficient neurorehabilitation in post stroke aphasia leads to clinical language improvements and promotes neuroplasticity. Brain areas frequently implicated in functional restitution of...
Aphasia Intensive language action therapy language MEG mismatch negativity neuroplasticity Adult Aged Aphasia Brain Brain Mapping Chronic Disease Female Functional Laterality Humans language Language Therapy Magnetoencephalography Male Middle Aged Neuronal Plasticity Recovery of Function speech Speech Perception stroke Stroke Rehabilitation Treatment Outcome
Imputation of Ordinal Outcomes
Kevin Kunzmann, Lorenz Wernisch, Sylvia Richardson, Ewout W Steyerberg, Hester Lingsma, Ari Ercole, Andrew IR Maas, David Menon, Lindsay Wilson
Oct 15, 2020
Loss to follow-up and missing outcomes data are important issues for longitudinal observational studies and clinical trials in traumatic brain injury. One popular solution to missing 6-month outcomes has been to use the last...
GOSe imputation missing data Traumatic brain injury Adolescent Adult Aged Aged 80 and over Brain Injuries Traumatic Child Child Preschool Data Interpretation Statistical Female Glasgow Outcome Scale Humans Infant Infant Newborn Male Middle Aged Models Neurological Prognosis Recovery of Function Research Design Young Adult
Neuroregeneration and plasticity
Neuronal networks, especially those in the central nervous system (CNS), evolved to support extensive functional capabilities while ensuring stability. Several physiological "brakes" that maintain the stability of the neuronal...
Higher Physiotherapy Frequency Is Associated with Shorter Length of Stay and Greater Functional Recovery in Hospitalized Frail Older Adults
Transcatheter Tricuspid Valve-in-Valve Replacement With Subsequent Bioprosthetic Valve Fracture to Optimize Hemodynamic Function.
Mark Hensey, Abdullah R Alenezi, Dale J Murdoch, Janarthanan Sathananthan, Jonathan R Weir-McCall, David Wood, Philipp Blanke, John Webb
Dec 21, 2018
transcatheter valve tricuspid valve Adult Balloon Valvuloplasty Bioprosthesis Cardiac Catheterization Female Heart valve prosthesis Heart Valve Prosthesis Implantation Hemodynamics Humans Prosthesis Design prosthesis failure Recovery of Function Treatment Outcome Tricuspid Valve Tricuspid Valve Insufficiency Tricuspid Valve Stenosis
Core Outcome Measures for Trials in People With Coronavirus Disease 2019
Allison Tong, Amanda Baumgart, Nicole Evangelidis, Andrea K Viecelli, Simon A Carter, Luciano Cesar Azevedo, Tess Cooper, Andrew Bersten, Lilia Cervantes, Derek P Chew, Sally Crowe, Ivor S Douglas, Ella Flemyng, Julian H Elliott, Elyssa Hannan, Peter Horby, Martin Howell, Angela Ju, Jaehee Lee, Eduardo Lorca, Deena Lynch, Karine E Manera, John C Marshall, Andrea Matus Gonzalez, Anne McKenzie, Sangeeta Mehta, Mervyn Mer, Andrew Conway Morris, Dale M Needham, Saad Nseir, Pedro Povoa, Mark Reid, Yasser Sakr, Ning Shen, Alan R Smyth, A John Simpson, Tom Snelling, Giovanni FM Strippoli, Armando Teixeira-Pinto, Antoni Torres, Tari Turner, Steve Webb, Paula R Williamson, Laila Woc-Colburn, Junhua Zhang, Jonathan C Craig, COVID-19-Core Outcomes Set Investigators
Nov 13, 2020
Targeted deletions of complement lectin pathway genes improve outcome in traumatic brain injury, with MASP-2 playing a major role.
D Mercurio, M Oggioni, S Fumagalli, NJ Lynch, S Roscher, D Minuta, C Perego, S Ippati, R Wallis, WJ Schwaeble, M-G De Simoni
Dec 14, 2020
The lectin pathway (LP) of complement activation is believed to contribute to brain inflammation. The study aims to identify the key components of the LP contributing to TBI outcome as possible novel pharmacological targets. We...
Complement cascade Lectin pathway MBL-associated serine protease Neuroinflammation Neurological deficits Pharmacological target Traumatic brain injury Animals Brain Brain Injuries Traumatic Collectins Complement C4b Complement Pathway Mannose-Binding Lectin Gene Deletion Inflammation Lectins Mannose-Binding Lectin Mannose-Binding Protein-Associated Serine Proteases Mice Mice Knockout Prognosis Recovery of Function
Immediate post-operative PDE5i therapy improves early erectile function outcomes after robot assisted radical prostatectomy (RARP).
Arjun Nathan, Shivani Shukla, Amil Sinha, Sailantra Sivathasan, Amir Rashid, Joseph Rassam, Sonny Smart, Keval Patel, Nimish Shah, Benjamin W Lamb
Feb 22, 2022
To assess whether the timing of post-operative Phosphodiesterase Inhibitor (PDE5i) therapy after Robot-Assisted Radical Prostatectomy (RARP) is associated with a change in early erectile function (EF) outcomes, continence or...
Interventional neurorehabilitation for promoting functional recovery post-craniotomy
Anujan Poologaindran, Christos Profyris, Isabella M Young, Nicholas B Dadario, Syed A Ahsan, Kassem Chendeb, Robert G Briggs, Charles Teo, Rafael Romero-Garcia, John Suckling, Michael E Sughrue
Feb 23, 2022
Stroke Prevention Rehabilitation Intervention Trial of Exercise (SPRITE) - a randomised feasibility study.
Neil Heron, Frank Kee, Jonathan Mant, Philip M Reilly, Margaret Cupples, Mark Tully, Michael Donnelly
Feb 09, 2018
Background
The value of cardiac rehabilitation (CR) after a transient ischaemic attack (TIA) or minor stroke is untested despite these conditions sharing similar pathology and risk factors to coronary heart disease. We aimed to...
Humans Ischemic Attack Transient Recurrence Treatment Outcome Exercise Therapy Risk Factors Feasibility Studies Health Knowledge Attitudes practice Patient Compliance motivation Recovery of Function Time Factors social support Aged Middle Aged Home Care Services Hospital-Based Northern Ireland Female Male Manuals as Topic Patient Education as Topic stroke Secondary Prevention Actigraphy Protective factors Stroke Rehabilitation Fitness Trackers
Robot Assisted Training for the Upper Limb after Stroke (RATULS)
Helen Rodgers, Lisa Shaw, Helen Bosomworth, Lydia Aird, Natasha Alvarado, Sreeman Andole, David L Cohen, Jesse Dawson, Janet Eyre, Tracy Finch, Gary A Ford, Jennifer Hislop, Steven Hogg, Denise Howel, Niall Hughes, Hermano Igo Krebs, Christopher Price, Lynn Rochester, Elaine Stamp, Laura Ternent, Duncan Turner, Luke Vale, Elizabeth Warburton, Frederike van Wijck, Scott Wilkes
Jul 21, 2017
BACKGROUND: Loss of arm function is a common and distressing consequence of stroke. We describe the protocol for a pragmatic, multicentre randomised controlled trial to determine whether robot-assisted training improves upper...
Arm Cost-effectiveness analysis Parallel process evaluation RCT Rehabilitation Robotics stroke Biomechanical Phenomena Clinical Protocols Cost-Benefit Analysis Disability Evaluation Exercise Therapy Health Care Costs Humans Models Economic Quality of life Quality-Adjusted Life Years Recovery of Function Research Design Robotics State Medicine stroke Stroke Rehabilitation Time Factors Treatment Outcome United Kingdom Upper Extremity
Total Hip Arthroplasty or Hemiarthroplasty for Hip Fracture.
HEALTH Investigators, Mohit Bhandari, Thomas A Einhorn, Gordon Guyatt, Emil H Schemitsch, Robert D Zura, Sheila Sprague, Frede Frihagen, Ernesto Guerra-Farfán, Ydo V Kleinlugtenbelt, Rudolf W Poolman, Amar Rangan, Sofia Bzovsky, Diane Heels-Ansdell, Lehana Thabane, Stephen D Walter, PJ Devereaux
Dec 11, 2019
BACKGROUND: Globally, hip fractures are among the top 10 causes of disability in adults. For displaced femoral neck fractures, there remains uncertainty regarding the effect of a total hip arthroplasty as compared with...
Olfactory sniffing signals consciousness in unresponsive patients with brain injuries.
Anat Arzi, Liron Rozenkrantz, Lior Gorodisky, Danit Rozenkrantz, Yael Holtzman, Aharon Ravia, Tristan A Bekinschtein, Tatyana Galperin, Ben-Zion Krimchansky, Gal Cohen, Anna Oksamitni, Elena Aidinoff, Yaron Sacher, Noam Sobel
May 06, 2020
After severe brain injury, it can be difficult to determine the state of consciousness of a patient, to determine whether the patient is unresponsive or perhaps minimally conscious1, and to predict whether they will recover....
Innate Lymphoid Cells Promote Recovery of Ventricular Function After Myocardial Infarction.
Xian Yu, Stephen A Newland, Tian X Zhao, Yuning Lu, Andrew S Sage, Yanyi Sun, Rouchelle S Sriranjan, Marcella Kl Ma, Brian YH Lam, Meritxell Nus, James E Harrison, Simon J Bond, Xiang Cheng, Jean-Sébastien Silvestre, James HF Rudd, Joseph Cheriyan, Ziad Mallat
Jul 20, 2021
BACKGROUND: Innate lymphoid cells type 2 (ILC2s) play critical homeostatic functions in peripheral tissues. ILC2s reside in perivascular niches and limit atherosclerosis development. OBJECTIVES: ILC2s also reside in the...
Towards prognostic functional brain biomarkers for cervical myelopathy
Shota Takenaka, Shigeyuki Kan, Ben Seymour, Takahiro Makino, Yusuke Sakai, Junichi Kushioka, Hisashi Tanaka, Yoshiyuki Watanabe, Masahiko Shibata, Hideki Yoshikawa, Takashi Kaito
Aug 02, 2019
Recently, there has been increasing interest in strategies to predict neurological recovery in cervical myelopathy (CM) based on clinical images of the cervical spine. In this study, we aimed to explore potential preoperative...
Cardiac αVβ3 integrin expression following acute myocardial infarction in humans.
William SA Jenkins, Alex T Vesey, Colin Stirrat, Martin Connell, Christophe Lucatelli, Anoushka Neale, Catriona Moles, Anna Vickers, Alison Fletcher, Tania Pawade, Ian Wilson, James HF Rudd, Edwin JR van Beek, Saeed Mirsadraee, Marc R Dweck, David E Newby
Nov 09, 2016
Aged Anterior Wall Myocardial Infarction Biomarkers Case-Control Studies Contrast Media Female Humans Inferior Wall Myocardial Infarction Integrin alphaVbeta3 Magnetic Resonance Imaging Male Middle Aged Myocardium Peptides Polyethylene Glycols Positron Emission Tomography Computed Tomography Recovery of Function ST Elevation Myocardial Infarction Time Factors Ventricular Function Left Ventricular Remodeling
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