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Long-term self-renewing human epicardial cells generated from pluripotent stem cells under defined xeno-free conditions.
Xiaoping Bao, Xiaojun Lian, Timothy A Hacker, Eric G Schmuck, Tongcheng Qian, Vijesh J Bhute, Tianxiao Han, Mengxuan Shi, Lauren Drowley, Alleyn Plowright, Qing-Dong Wang, Marie-Jose Goumans, Sean P Palecek
Jun 21, 2018
The epicardium contributes both multi-lineage descendants and paracrine factors to the heart during cardiogenesis and cardiac repair, underscoring its potential for cardiac regenerative medicine. Yet little is known about the...
0601 Biochemistry and Cell Biology Biomedical Basic Science Stem Cell Research - Induced Pluripotent Stem Cell - Human Cardiovascular Stem Cell Research Heart Disease Stem Cell Research - Embryonic - Human Stem Cell Research - Induced Pluripotent Stem Cell Regenerative Medicine Cardiovascular 1.1 Normal biological development and functioning
When Bio Meets Technology
Amy E Rochford, Alejandro Carnicer-Lombarte, Vincenzo F Curto, George G Malliaras, Damiano G Barone
Aug 29, 2019
TGFβ signalling is required to maintain pluripotency of human naïve pluripotent stem cells.
Anna Osnato, Stephanie Brown, Christel Krueger, Simon Andrews, Amanda J Collier, Shota Nakanoh, Mariana Quiroga Londoño, Brandon T Wesley, Daniele Muraro, A Sophie Brumm, Kathy K Niakan, Ludovic Vallier, Daniel Ortmann, Peter J Rugg-Gunn
Oct 01, 2021
Published by: eLife
The myeloid lineage is required for the emergence of a regeneration-permissive environment following Xenopus tail amputation.
Can Aztekin, Tom W Hiscock, Richard Butler, Francisco De Jesús Andino, Jacques Robert, John B Gurdon, Jerome Jullien
Jan 16, 2020
Regeneration-competent vertebrates are considered to suppress inflammation faster than non-regenerating ones. Hence, understanding the cellular mechanisms affected by immune cells and inflammation can help develop strategies to...
Assessing the Safety of Human Pluripotent Stem Cells and Their Derivatives for Clinical Applications
Peter W Andrews, Uri Ben-David, Nissim Benvenisty, Peter Coffey, Kevin Eggan, Barbara B Knowles, Andras Nagy, Martin Pera, Benjamin Reubinoff, Peter J Rugg-Gunn, Glyn N Stacey
Jan 25, 2018
Generation of human vascular smooth muscle subtypes provides insight into embryological origin-dependent disease susceptibility.
Christine Cheung, Andreia S Bernardo, Matthew WB Trotter, Roger A Pedersen, Sanjay Sinha
Jan 23, 2018
Heterogeneity of embryological origins is a hallmark of vascular smooth muscle cells (SMCs) and may influence the development of vascular disease. Differentiation of human pluripotent stem cells (hPSCs) into developmental...
Substrate Specificity and Biochemical Characteristics of an Engineered Mammalian Chondroitinase ABC.
Chondroitin sulfate proteoglycans inhibit regeneration, neuroprotection, and plasticity following spinal cord injury. The development of a second-generation chondroitinase ABC enzyme, capable of being secreted from mammalian...
Advances in Applications of Metabolomics in Pluripotent Stem Cell Research.
Stem cells undergo extensive metabolic rewiring during reprogramming, proliferation and differentiation, and numerous studies have demonstrated a significant role of metabolism in controlling stem cell fates. Recent applications...
0601 Biochemistry and Cell Biology Biomedical Basic Science Stem Cell Research - Induced Pluripotent Stem Cell - Human Stem Cell Research Stem Cell Research - Nonembryonic - Human Stem Cell Research - Embryonic - Non-Human Stem Cell Research - Induced Pluripotent Stem Cell Regenerative Medicine Generic Health Relevance 5.2 Cellular and gene therapies
Biomimetic and electroactive 3D scaffolds for human neural crest-derived stem cell expansion and osteogenic differentiation
Abstract Osteoporosis is a skeletal disease characterized by bone loss and bone microarchitectural deterioration. The combination of smart materials and stem cells represents a new therapeutic...
D Iandolo, J Sheard, G Karavitas Levy, C Pitsalidis, E TAN, A Dennis, JS Kim, AE Markaki, D Widera, RM Owens
Sep 20, 2021
scRNA-Seq reveals distinct stem cell populations that drive hair cell regeneration after loss of Fgf and Notch signaling.
Mark E Lush, Daniel C Diaz, Nina Koenecke, Sungmin Baek, Helena Boldt, Madeleine K St Peter, Tatiana Gaitan-Escudero, Andres Romero-Carvajal, Elisabeth M Busch-Nentwich, Anoja G Perera, Kathryn E Hall, Allison Peak, Jeffrey S Haug, Tatjana Piotrowski
Apr 29, 2019
Loss of sensory hair cells leads to deafness and balance deficiencies. In contrast to mammalian hair cells, zebrafish ear and lateral line hair cells regenerate from poorly characterized support cells. Equally ill-defined is the...
A Systematic Review And Meta-Analysis of Clinical Trials of Mesenchymal Stem Cell Therapy for Cartilage Repair.
BACKGROUND: Osteoarthritis (OA) is a major global burden creating significant morbidity worldwide. Current curative therapies are expensive, challenging to access and have significant risks, making them infeasible and difficult...
Neuronal Reprogramming for Tissue Repair and Neuroregeneration.
Stem cell and cell reprogramming technology represent a rapidly growing field in regenerative medicine. A number of novel neural reprogramming methods have been established, using pluripotent stem cells (PSCs) or direct...
Innovations, challenges, and minimal information for standardization of humanized mice.
Renata Stripecke, Christian Münz, Jan Jacob Schuringa, Karl-Dimiter Bissig, Brian Soper, Terrence Meeham, Li-Chin Yao, James P Di Santo, Michael Brehm, Estefania Rodriguez, Anja Kathrin Wege, Dominique Bonnet, Silvia Guionaud, Kristina E Howard, Scott Kitchen, Florian Klein, Kourosh Saeb-Parsy, Johannes Sam, Amar Deep Sharma, Andreas Trumpp, Livio Trusolino, Carol Bult, Leonard Shultz
Jul 31, 2020
Mice xenotransplanted with human cells and/or expressing human gene products (also known as "humanized mice") recapitulate the human evolutionary specialization and diversity of genotypic and phenotypic traits. These models can...
Infrapatellar fat pad adipose-derived stem cells co-cultured with articular chondrocytes from osteoarthritis patients exhibit increased chondrogenic gene expression.
AIM: The variable results in clinical trials of adipose tissue-derived stem cells (ASCs) for chondral defects may be due to the different ex vivo culture conditions of the ASCs which are implanted to treat the lesions. We sought...
Neural Conversion and Patterning of Human Pluripotent Stem Cells
Stem Cell Research - Embryonic - Non-Human Stem Cell Research - Embryonic - Human Stem Cell Research - Nonembryonic - Non-Human Regenerative Medicine Neurosciences Stem Cell Research Stem Cell Research - Induced Pluripotent Stem Cell Stem Cell Research - Induced Pluripotent Stem Cell - Human 1 Underpinning research 1.1 Normal biological development and functioning Generic Health Relevance
Tailless/TLX reverts intermediate neural progenitors to stem cells driving tumourigenesis via repression of asense/ASCL1.
Understanding the sequence of events leading to cancer relies in large part upon identifying the tumour cell of origin. Glioblastoma is the most malignant brain cancer but the early stages of disease progression remain elusive....
D. melanogaster TLX Dedifferentiation developmental biology Glioblastoma neural stem cell Regenerative Medicine Stem Cells tailless tumourigenesis Animals Carcinogenesis Cell Differentiation Cell Lineage Cell Transformation Neoplastic Drosophila Proteins Drosophila melanogaster Female Glioblastoma Humans Male Nerve Tissue Proteins Neural Stem Cells Repressor Proteins Stem Cells
An ex vivo model using human osteoarthritic cartilage demonstrates the release of bioactive insulin-like growth factor-1 from a collagen-glycosaminoglycan scaffold.
Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun.
Laura J Wagstaff, Jose A Gomez-Sanchez, Shaline V Fazal, Georg W Otto, Alastair M Kilpatrick, Kirolos Michael, Liam YN Wong, Ki H Ma, Mark Turmaine, John Svaren, Tessa Gordon, Peter Arthur-Farraj, Sergio Velasco-Aviles, Hugo Cabedo, Cristina Benito, Rhona Mirsky, Kristjan R Jessen
Mar 15, 2021
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during chronic denervation that...
BAP1/ASXL complex modulation regulates epithelial-mesenchymal transition during trophoblast differentiation and invasion.
Vicente Perez-Garcia, Georgia Lea, Pablo Lopez-Jimenez, Hanneke Okkenhaug, Graham J Burton, Ashley Moffett, Margherita Y Turco, Myriam Hemberger
Sep 05, 2021
Normal function of the placenta depends on the earliest developmental stages when trophoblast cells differentiate and invade into the endometrium to establish the definitive maternal-fetal interface. Previously, we identified...
CRISPR gene editing developmental biology Epithelial-Mesenchymal Transition human MOUSE Placenta Regenerative Medicine stem cell self-renewal Stem Cells trophoblast trophoblast invasion Animals Cell Differentiation Epithelial-Mesenchymal Transition Gene Expression Regulation Humans Mice Repressor Proteins Trophoblasts Tumor Suppressor Proteins Ubiquitin Thiolesterase
Recent Advances in Microgels
Yufan Xu, Hongjia Zhu, Akhila Denduluri, Yangteng Ou, Nadia A Erkamp, Runzhang Qi, Yi Shen, Tuomas PJ Knowles
Jul 05, 2022
Vinculin recruitment to α-catenin halts the differentiation and maturation of enterocyte progenitors to maintain homeostasis of the Drosophila intestine.
Mechanisms communicating changes in tissue stiffness and size are particularly relevant in the intestine because it is subject to constant mechanical stresses caused by peristalsis of its variable content. Using the Drosophila...
3D Bioelectronics with a Remodellable Matrix for Long-Term Tissue Integration and Recording.
Alexander J Boys, Alejandro Carnicer-Lombarte, Amparo Güemes-Gonzalez, Douglas C van Niekerk, Sam Hilton, Damiano G Barone, Christopher M Proctor, Róisín M Owens, George G Malliaras
Dec 21, 2022
Bioelectronics hold the key for understanding and treating disease. However, achieving stable, long-term interfaces between electronics and the body remains a challenge. Implantation of a bioelectronic device typically initiates...
Current treatments after spinal cord injury
Both traumatic and non‐traumatic spinal cord injuries (SCIs) can be categorized as damages done to our central nervous system (CNS). The patients' physical and mental health may suffer greatly because of traumatic SCI. With the...
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