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Results: 232
The global variation of medical student engagement in teaching
Introduction: International medical electives, whereby undergraduates visit an institution in a country other than their own, are a common part of medical training. Visiting students are often asked to provide local teaching...
Responses among substance abuse treatment providers to the opioid epidemic in the USA
Objective: To identify the geographic, organisational, and payment correlates of buprenorphine and methadone treatment among substance abuse treatment (SAT) providers. Methods: Secondary analyses of the National Survey of...
Fatty acids in the de novo lipogenesis pathway and incidence of type 2 diabetes
Fumiaki Imamura, Amanda M. Fretts, Matti Marklund, Andres V. Ardisson Korat, Wei-Sin Yang, Maria Lankinen, Waqas Qureshi, Catherine Helmer, Tzu-An Chen, Jyrki K. Virtanen, Kerry Wong, Julie K. Bassett, Rachel Murphy, Nathan Tintle, Chaoyu Ian Yu, Ingeborg A. Brouwer, Kuo-Liong Chien, Yun-Yu Chen, Alexis C. Wood, Liana C. del Gobbo, Luc Djousse, Johanna M. Geleijnse, Graham G. Giles, Janette de Goede, Vilmundur Gudnason, William S. Harris, Allison Hodge, Frank Hu, InterAct Consortium, Albert Koulman, Markku Laakso, Lars Lind, Hung-Ju Lin, Barbara McKnight, Kalina Rajaobelina, Ulf Riserus, Jennifer G. Robinson, Cecilia Samieri, Mackenzie Senn, David S. Siscovick, Sabita S. Soedamah-Muthu, Nona Sotoodehnia, Qi Sun, Michael Y. Tsai, Tomi-Pekka Tuomainen, Matti Uusitupa, Lynne E. Wagenknecht, Nick J. Wareham, Jason H. Y. Wu, Renata Micha, Rozenn N. Lemaitre, Dariush Mozaffarian, Nita G. Forouhi
Jun 12, 2020
Trappc9 deficiency causes parent-of-origin dependent microcephaly and obesity
Zhengzheng S. Liang, Irene Cimino, Binnaz Yalcin, Narayanan Raghupathy, Valerie E. Vancollie, Ximena Ibarra-Soria, Helen V. Firth, Debra Rimmington, I. Sadaf Farooqi, Christopher J. Lelliott, Steven C. Munger, Stephen O’Rahilly, Anne C. Ferguson-Smith, Anthony P. Coll, Darren W. Logan
Sep 02, 2020
Some imprinted genes exhibit parental origin specific expression bias rather than being transcribed exclusively from one copy. The physiological relevance of this remains poorly understood. In an analysis of brain-specific...
Intracellular neutralisation of rotavirus by VP6-specific IgG
Sarah L. Caddy, Marina Vaysburd, Mark Wing, Stian Foss, Jan Terje Andersen, Kevin O‘Connell, Keith Mayes, Katie Higginson, Miren Iturriza-Gómara, Ulrich Desselberger, Leo C. James
Aug 14, 2020
Impact of duration and magnitude of raised intracranial pressure on outcome after severe traumatic brain injury
Cecilia AI Åkerlund, Joseph Donnelly, Frederick A. Zeiler, Raimund Helbok, Anders Holst, Manuel Cabeleira, Fabian Güiza, Geert Meyfroidt, Marek Czosnyka, Peter Smielewski, Nino Stocchetti, Ari Ercole, David W. Nelson, the CENTER-TBI High Resolution ICU Sub-Study Participants and Investigators
Dec 22, 2020
Magnitude of intracranial pressure (ICP) elevations and their duration have been associated with worse outcomes in patients with traumatic brain injuries (TBI), however published thresholds for injury vary and uncertainty about...
A novel terpene synthase controls differences in anti-aphrodisiac pheromone production between closely related Heliconius butterflies
Kathy Darragh, Anna Orteu, Daniella Black, Kelsey J. R. P. Byers, Daiane Szczerbowski, Ian A. Warren, Pasi Rastas, Ana Pinharanda, John W. Davey, Sylvia Fernanda Garza, Diana Abondano Almeida, Richard M. Merrill, W. Owen McMillan, Stefan Schulz, Chris D. Jiggins
Jan 19, 2021
Periodic synchronisation of dengue epidemics in Thailand over the last 5 decades driven by temperature and immunity.
Bernardo García-Carreras, Bingyi Yang, Mary K Grabowski, Lawrence W Sheppard, Angkana Huang, Henrik Salje, Hannah Eleanor Clapham, Sopon Iamsirithaworn, Pawinee Doung-Ngern, Justin Lessler, Derek AT Cummings
Mar 31, 2022
The spatial distribution of dengue and its vectors (spp. Aedes) may be the widest it has ever been, and projections suggest that climate change may allow the expansion to continue. However, less work has been done to understand...
Hypoglycaemia due to insulin therapy for the management of hyperkalaemia in hospitalised adults
Mogamat-Yazied Chothia, Toby Humphrey, Anel Schoonees, Usuf Mohamed Ebrahim Chikte, Mogamat Razeen Davids
May 12, 2022
INTRODUCTION: Hyperkalaemia is a very common electrolyte disorder encountered in hospitalised patients. Although hypoglycaemia is a frequent complication of insulin therapy, it is often under-appreciated. We conducted a scoping...
Responses and sensitivities of maize phenology to climate change from 1971 to 2020 in Henan Province, China.
Climate change affects many aspects of the physiological and biochemical processes of growing maize and ultimately its yield. A comprehensive climate suitability model is proposed that quantifies the effects of temperature...
Quantifying patterns of alcohol consumption and its effects on health and wellbeing among BaYaka hunter-gatherers
Jessica K Knight, Gul Deniz Salali, Gaurav Sikka, Inez Derkx, Sarai M Keestra, Nikhil Chaudhary
Oct 28, 2021
Climatic change and extinction risk of two globally threatened Ethiopian endemic bird species
Andrew J. Bladon, Paul F. Donald, Nigel J. Collar, Jarso Denge, Galgalo Dadacha, Mengistu Wondafrash, Rhys E. Green
May 20, 2021
Cross-sectional study of approaches to diagnosis and management of dogs with immune-mediated haemolytic anaemia in primary care and referral veterinary practices in the United Kingdom
James W. Swann, Sarah Tayler, Harriet Hall, Richard Sparrow, Barbara J. Skelly, Barbara Glanemann
Sep 20, 2021
Objectives: To determine whether veterinarians in primary care practices (PCPs) and board-certified clinicians (BCCs) approach treatment of dogs with immune-mediated haemolytic anaemia (IMHA) similarly, and whether practitioners...
Evaluation of transabdominal and transperineal ultrasound-derived prostate specific antigen (PSA) density and clinical utility compared to MRI prostate volumes
Maria Pantelidou, Iztok Caglic, Anne George, Oleg Blyuss, Vincent J Gnanapragasam, Tristan Barrett
Sep 09, 2022
PURPOSE: To investigate the accuracy of surface-based ultrasound-derived PSA-density (US-PSAD) versus gold-standard MRI-PSAD as a risk-stratification tool. METHODS: Single-centre prospective study of patients undergoing MRI for...
High-order functional redundancy in ageing explained via alterations in the connectome in a whole-brain model.
Marilyn Gatica, Fernando E Rosas, Pedro A M Mediano, Ibai Diez, Stephan P Swinnen, Patricio Orio, Rodrigo Cofré, Jesus M Cortes
Sep 15, 2022
The predictive value of abnormal P-wave axis for the detection of incident atrial fibrillation
Rahul Kumar Chattopadhyay, Panagiota Anna Chousou, Trisha Mukherjee, Peter John Pugh, Vassilios S Vassiliou
Dec 08, 2022
INTRODUCTION: There is growing interest in the prediction of incident atrial fibrillation (AF). The 12-lead electrocardiogram (ECG) has been a particularly rich target for possible prediction strategies. PURPOSE: The P-wave axis...
Directed acyclic graphs in perioperative observational research–A systematic review and critique against best practice recommendations
Matthew Lamont Watson, Sebastian HM Hickman, Kaya Marlen Dreesbeimdiek, Katharina Kohler, Daniel J Stubbs
Feb 09, 2023
Residential neighbourhood greenspace is associated with reduced risk of cardiovascular disease
Background: Living in a greener neighbourhood may reduce the risk of developing incident cardiovascular disease, but evidence is limited by reliance on cross-sectional comparisons. We use data from a longitudinal study with a...
Potential gains in life expectancy from reducing amenable mortality among people diagnosed with serious mental illness in the United Kingdom
Alex Dregan, Ann McNeill, Fiona Gaughran, Peter B. Jones, Anna Bazley, Sean Cross, Kate Lillywhite, David Armstrong, Shubulade Smith, David P. J. Osborn, Robert Stewart, Til Wykes, Matthew Hotopf
Mar 27, 2020
Background: To estimate the potential gain in life expectancy from addressing modifiable risk factors for all-cause mortality (excluding suicide and deaths from accidents or violence) across specific serious mental illness (SMI)...
Characterizing Emerging Canine H3 Influenza Viruses
Luis Martinez-Sobrido, Pilar Blanco-Lobo, Laura Rodriguez, Theresa Fitzgerald, Hanyuan Zhang, Phuong Nguyen, Christopher S. Anderson, Jeanne Holden-Wiltse, Sanjukta Bandyopadhyay, Aitor Nogales, Marta L. DeDiego, Brian R. Wasik, Benjamin L. Miller, Carole Henry, Patrick C. Wilson, Mark Y. Sangster, John J. Treanor, David J. Topham, Lauren Byrd-Leotis, David A. Steinhauer, Richard D. Cummings, Jasmina M. Luczo, Stephen M. Tompkins, Kaori Sakamoto, Cheryl A. Jones, John Steel, Anice C. Lowen, Shamika Danzy, Hui Tao, Ashley L. Fink, Sabra L. Klein, Nicholas Wohlgemuth, Katherine J. Fenstermacher, Farah El Najjar, Andrew Pekosz, Lauren Sauer, Mitra K. Lewis, Kathryn Shaw-Saliba, Richard E. Rothman, Zhen-Ying Liu, Kuan-Fu Chen, Colin R. Parrish, Ian E. H. Voorhees, Yoshihiro Kawaoka, Gabriele Neumann, Shiho Chiba, Shufang Fan, Masato Hatta, Huihui Kong, Gongxun Zhong, Guojun Wang, Melissa B. Uccellini, Adolfo García-Sastre, Daniel R. Perez, Lucas M. Ferreri, Sander Herfst, Mathilde Richard, Ron Fouchier, David Burke, David Pattinson, Derek J. Smith, Victoria Meliopoulos, Pamela Freiden, Brandi Livingston, Bridgett Sharp, Sean Cherry, Juan Carlos Dib, Guohua Yang, Charles J. Russell, Subrata Barman, Richard J. Webby, Scott Krauss, Angela Danner, Karlie Woodard, Malik Peiris, R. A. P. M. Perera, M. C. W. Chan, Elena A. Govorkova, Bindumadhav M. Marathe, Philippe N. Q. Pascua, Gavin Smith, Yao-Tsun Li, Paul G. Thomas, Stacey Schultz-Cherry
Apr 24, 2020
The continual emergence of novel influenza A strains from non-human hosts requires constant vigilance and the need for ongoing research to identify strains that may pose a human public health risk. Since 1999, canine H3...
Pooling individual participant data from randomized controlled trials
Lennard L. van Wanrooij, Marieke P. Hoevenaar-Blom, Nicola Coley, Tiia Ngandu, Yannick Meiller, Juliette Guillemont, Anna Rosenberg, Cathrien R. L. Beishuizen, Eric P. Moll van Charante, Hilkka Soininen, Carol Brayne, Sandrine Andrieu, Miia Kivipelto, Edo Richard
May 12, 2020
Background: Pooling individual participant data to enable pooled analyses is often complicated by diversity in variables across available datasets. Therefore, recoding original variables is often necessary to build a pooled...
Interventions to reduce social isolation and loneliness during COVID-19 physical distancing measures
Christopher Y. K. Williams, Adam T. Townson, Milan Kapur, Alice F. Ferreira, Rebecca Nunn, Julieta Galante, Veronica Phillips, Sarah Gentry, Juliet A. Usher-Smith
Feb 17, 2021
Background: A significant proportion of the worldwide population is at risk of social isolation and loneliness as a result of the COVID-19 pandemic. We aimed to identify effective interventions to reduce social isolation and...
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