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Results: 11
Cover Image for Cardiac involvement in hereditary myopathy with early respiratory failure View Article
Cardiac involvement in hereditary myopathy with early respiratory failure
Hannah E Steele, Elizabeth Harris, Rita Barresi, Julie Marsh, Anna Beattie, John P Bourke, Volker Straub, Patrick F Chinnery
Apr 26, 2016
Adolescent Adult Arrhythmias Cardiac Blotting Western Cohort Studies Connectin Electrocardiography Female Genetic Diseases Inborn Heart Humans Immunohistochemistry Magnetic Resonance Imaging Male Middle Aged Muscular Diseases Mutation Missense Myocardium Phenotype Respiratory Insufficiency Tomography X-Ray Computed Young Adult
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Cover Image for Genetic Risk of Severe Covid-19. View Article
Genetic Risk of Severe Covid-19.
Arthur Kaser
Oct 05, 2020
Betacoronavirus covid-19 Coronavirus Infections Genome-Wide Association Study Humans Pandemics Pneumonia Viral Respiratory Insufficiency SARS-CoV-2
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Cover Image for Reply View Article
Reply
Gerald Pfeffer, Helen Griffin, Angela Pyle, Rita Horvath, Patrick F Chinnery
Mar 07, 2019
Female Humans Male Muscle Proteins Muscular Diseases Mutation Protein Kinases Respiratory Insufficiency
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Cover Image for The excess insulin requirement in severe COVID-19 compared to non-COVID-19 viral pneumonitis is related to the severity of respiratory failure and pre-existing diabetes. View Article
The excess insulin requirement in severe COVID-19 compared to non-COVID-19 viral pneumonitis is related to the severity of respiratory failure and pre-existing diabetes.
Sam M Lockhart, Harry Griffiths, Bogdan Petrisor, Ammara Usman, Julia Calvo-Latorre, Laura Heales, Vishakha Bansiya, Razeen Mahroof, Andrew Conway Morris
Jan 11, 2021
COVID‐19 Diabetes Insulin Resistance stress hyperglycaemia covid-19 Diabetes mellitus Type 1 Diabetes mellitus Type 2 Dose-Response Relationship Drug Female Humans Hypoglycemic Agents Insulin Male Respiratory Insufficiency
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Cover Image for Core Outcome Measures for Trials in People With Coronavirus Disease 2019 View Article
Core Outcome Measures for Trials in People With Coronavirus Disease 2019
Allison Tong, Amanda Baumgart, Nicole Evangelidis, Andrea K Viecelli, Simon A Carter, Luciano Cesar Azevedo, Tess Cooper, Andrew Bersten, Lilia Cervantes, Derek P Chew, Sally Crowe, Ivor S Douglas, Ella Flemyng, Julian H Elliott, Elyssa Hannan, Peter Horby, Martin Howell, Angela Ju, Jaehee Lee, Eduardo Lorca, Deena Lynch, Karine E Manera, John C Marshall, Andrea Matus Gonzalez, Anne McKenzie, Sangeeta Mehta, Mervyn Mer, Andrew Conway Morris, Dale M Needham, Saad Nseir, Pedro Povoa, Mark Reid, Yasser Sakr, Ning Shen, Alan R Smyth, A John Simpson, Tom Snelling, Giovanni FM Strippoli, Armando Teixeira-Pinto, Antoni Torres, Tari Turner, Steve Webb, Paula R Williamson, Laila Woc-Colburn, Junhua Zhang, Jonathan C Craig, COVID-19-Core Outcomes Set Investigators
Nov 13, 2020
covid-19 Clinical Trials as Topic Dyspnea Humans Multiple Organ Failure Outcome Assessment Health Care Practice Guidelines as Topic Recovery of Function Reproducibility of Results Research Design Respiratory Insufficiency
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Cover Image for Whole-blood Point-of-Care Activated Partial Thromboplastin Time Ratio (APR) is not Accurate Enough to Monitor Heparin Therapy in Patients with Severe Respiratory Failure Secondary to SARS-Cov-2 Infection Supported with Veno-Venous Extracorporeal Membrane Oxygenation (VV-ECMO). View Article
Whole-blood Point-of-Care Activated Partial Thromboplastin Time Ratio (APR) is not Accurate Enough to Monitor Heparin Therapy in Patients with Severe Respiratory Failure Secondary to SARS-Cov-2 Infection Supported with Veno-Venous Extracorporeal Membrane Oxygenation (VV-ECMO).
Daniel Aston, Martin Besser, Ben Goddard, Nicholas Maggs, Hassan Ahmed, Florian Falter
Jan 04, 2023
SARS-CoV-2 Anticoagulants Coagulation heparins Humans Partial Thromboplastin Time Heparin Extracorporeal membrane oxygenation Point-of-Care Systems covid-19 SARS-CoV-2 Anticoagulants Respiratory Insufficiency Retrospective Studies
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Cover Image for Genetically proxied interleukin-6 receptor inhibition View Article
Genetically proxied interleukin-6 receptor inhibition
Susanna C Larsson, Stephen Burgess, Dipender Gill
Nov 03, 2020
Respiratory disease is a main feature of severe COVID-19, and the potential of IL-6 receptor blockade to increase risk of pneumonia warrants vigilance and caution in its application to treat COVID-19 https://bit.ly/34Y8Ner
C-Reactive Protein covid-19 Genetic Predisposition to Disease Hospitalization Humans Mendelian Randomization Analysis Pneumonia Polymorphism Single Nucleotide Receptors Interleukin-6 Respiratory Insufficiency SARS-CoV-2 Severity of Illness Index White People COVID-19 Drug Treatment
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Cover Image for Outcomes of the NHS England National Extracorporeal Membrane Oxygenation Service for adults with respiratory failure View Article
Outcomes of the NHS England National Extracorporeal Membrane Oxygenation Service for adults with respiratory failure
Alex Warren, Yi-da Chiu, Sofía S Villar, Jo-Anne Fowles, Nicola Symes, Julian Barker, Luigi Camporota, Chris Harvey, Stephane Ledot, Ian Scott, Alain Vuylsteke, NHS England-commissioned National ECMO Service
Jul 02, 2020
BACKGROUND: Extracorporeal membrane oxygenation (ECMO) is increasingly used to support adults with severe respiratory failure refractory to conventional measures. In 2011, NHS England commissioned a national service to provide...
ARDS ECMO National Health Service Extracorporeal membrane oxygenation Mechanical ventilation respiratory failure Adult Cohort Studies England Extracorporeal membrane oxygenation Female Humans Male Middle Aged Prospective Studies Respiratory Insufficiency State Medicine Treatment Outcome
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Cover Image for Acute hypoxaemic respiratory failure in a low-income country View Article
Acute hypoxaemic respiratory failure in a low-income country
Arthur Kwizera, Jane Nakibuuka, Lydia Nakiyingi, Cornelius Sendagire, Janat Tumukunde, Catherine Katabira, Ronald Ssenyonga, Noah Kiwanuka, David Patrick Kateete, Moses Joloba, Daphne Kabatoro, Diana Atwine, Charlotte Summers
Dec 01, 2020
INTRODUCTION: Limited data exist on the epidemiology of acute hypoxaemic respiratory failure (AHRF) in low-income countries (LICs). We sought to determine the prevalence of AHRF in critically ill adult patients admitted to a...
ARDS clinical epidemiology Respiratory Infection Adult Humans Hypoxia Male prevalence Prospective Studies Respiratory Insufficiency Tertiary Care Centers
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Cover Image for Proteome-wide Mendelian randomization identifies causal links between blood proteins and severe COVID-19. View Article
Proteome-wide Mendelian randomization identifies causal links between blood proteins and severe COVID-19.
Alish B Palmos, Vincent Millischer, David K Menon, Timothy R Nicholson, Leonie S Taams, Benedict Michael, Geraint Sunderland, Michael J Griffiths, COVID Clinical Neuroscience Study Consortium, Christopher Hübel, Gerome Breen
Mar 03, 2022
Biomarkers Blood Proteins covid-19 Causality Genome-Wide Association Study Hospitalization Humans Mendelian Randomization Analysis Mortality Pandemics Polymorphism Single Nucleotide Prognosis Proteome Respiratory Insufficiency Risk Factors SARS-CoV-2 Severity of Illness Index
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Cover Image for A randomised trial of anti-GM-CSF otilimab in severe COVID-19 pneumonia (OSCAR). View Article
A randomised trial of anti-GM-CSF otilimab in severe COVID-19 pneumonia (OSCAR).
Jatin Patel, Damon Bass, Albertus Beishuizen, Xavier Bocca Ruiz, Hatem Boughanmi, Anthony Cahn, Hugo Colombo, Gerard J Criner, Katherine Davy, Javier de-Miguel-Díez, Pablo A Doreski, Sofia Fernandes, Bruno François, Anubha Gupta, Kate Hanrott, Timothy Hatlen, Dave Inman, John D Isaacs, Emily Jarvis, Natalia Kostina, Tatiana Kropotina, Jean-Claude Lacherade, Divya Lakshminarayanan, Pedro Martinez-Ayala, Charlene McEvoy, Ferhat Meziani, Mehran Monchi, Sumanta Mukherjee, Rosana Muñoz-Bermúdez, Jessica Neisen, Ciara O'Shea, Gaëtan Plantefeve, Lorrie Schifano, Lee E Schwab, Zainab Shahid, Michinori Shirano, Julia E Smith, Eduardo Sprinz, Charlotte Summers, Nicolas Terzi, Mark A Tidswell, Yuliya Trefilova, Russell Williamson, Duncan Wyncoll, Mark Layton
Nov 16, 2022
BACKGROUND: Granulocyte-macrophage colony-stimulating factor (GM-CSF) and dysregulated myeloid cell responses are implicated in the pathophysiology and severity of COVID-19. METHODS: In this randomised, sequential, multicentre...
Adult Humans covid-19 Granulocyte-Macrophage Colony-Stimulating Factor Antibodies Monoclonal Humanized Respiratory Insufficiency Double-Blind Method Treatment Outcome
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