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PURPOSE: To characterize the retinal expression and localization of Kcne2, an ancillary (β) ion-channel subunit with an important role in fine-tuning cellular excitability. METHODS: We analyzed available single-cell...

Animals CHO Cells Computational Biology Cricetulus Gene Expression Regulation Immunohistochemistry Macaca mulatta Mice Mice Inbred C57BL Microscopy Confocal Potassium Channels Voltage-Gated Retinal Bipolar Cells Retinal Cone Photoreceptor Cells Retinal Rod Photoreceptor Cells Sheep Songbirds Synapses Transfection Zebrafish

cone photoreceptors Dark Adaptation electroretinographyy Retina Retinal Bipolar Cells rod photoreceptors Humans Dark Adaptation Retinaldehyde Retinal Rod Photoreceptor Cells Photic Stimulation Electroretinography Retinal Cone Photoreceptor Cells Retina Opsins

In Moscow in the 1950's, the physicist M. M. Bongard developed the use of silent substitution to establish the number of dimensions of human or animal colour vision and to derive colour-matching functions either for whole...

Colour matching functions Melanopsin peripheral vision Rods Silent substitution Tetrachromacy Animals Color Perception Color Vision Color Vision Defects Humans Male Retinal Ganglion Cells Retinal Rod Photoreceptor Cells

RP2 mutations cause a severe form of X-linked retinitis pigmentosa (XLRP). The mechanism of RP2-associated retinal degeneration in humans is unclear, and animal models of RP2 XLRP do not recapitulate this severe phenotype. Here...

AAV CRISPR gene editing Cell Death Disease Modeling gene therapy Genetic inherited disease Retinal Degeneration retinal organoid stem cell Cell Death Cell Survival Dependovirus GTP-Binding Proteins Gene Expression Regulation Gene Knockdown Techniques Humans Induced Pluripotent Stem Cells Membrane Proteins Models Biological Organoids Retina Retinal Rod Photoreceptor Cells Retinitis Pigmentosa

Animals detect light using opsin photopigments. Xenopsin, a recently classified subtype of opsin, challenges our views on opsin and photoreceptor evolution. Originally thought to belong to the Gαi-coupled ciliary opsins...

Maritigrella crozieri ciliary photoreceptor developmental biology evolutionary biology flatworm phaosome photopigment xenopsin Animals Brain Cell Membrane evolution Molecular Eye GTP-Binding Protein alpha Subunits Humans Larva Light Signal Transduction Opsins Peptides Photoreceptor Cells Photoreceptor Cells Invertebrate Photoreceptor Cells Vertebrate Phylogeny Platyhelminths Retinal Rod Photoreceptor Cells Sequence Alignment Sequence Analysis Protein Xenopus Proteins