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Host-pathogen coevolution increases genetic variation in susceptibility to infection
Elizabeth ML Duxbury, Jonathan P Day, Davide Maria Vespasiani, Yannik Thüringer, Ignacio Tolosana, Sophia CL Smith, Lucia Tagliaferri, Altug Kamacioglu, Imogen Lindsley, Luca Love, Robert L Unckless, Francis Jiggins, Ben Longdon
Apr 26, 2019
It is common to find considerable genetic variation in susceptibility to infection in natural populations. We have investigated whether natural selection increases this variation by testing whether host populations show more...
D. melanogaster Drosophila coevolution evolutionary biology sigma virus Virus viruses Alleles Animals Chromosome Mapping Disease Resistance Disease Susceptibility Drosophila melanogaster Female Genes Insect genetic variation Host-Pathogen Interactions Infections Male Polymorphism Genetic rhabdoviridae Rhabdoviridae Infections selection Genetic Species Specificity Viral Load
TNFα Impairs Rhabdoviral Clearance by Inhibiting the Host Autophagic Antiviral Response.
Raquel Espín-Palazón, Alicia Martínez-López, Francisco J Roca, Azucena López-Muñoz, Sylwia D Tyrkalska, Sergio Candel, Diana García-Moreno, Alberto Falco, José Meseguer, Amparo Estepa, Victoriano Mulero
May 13, 2019
TNFα is a pleiotropic pro-inflammatory cytokine with a key role in the activation of the immune system to fight viral infections. Despite its antiviral role, a few viruses might utilize the host produced TNFα to their benefit....
The genetic architecture of resistance to virus infection in Drosophila.
Experimental Lagos bat virus infection in straw-colored fruit bats
Lineke Begeman, Richard Suu-Ire, Ashley C Banyard, Christian Drosten, Elisa Eggerbauer, Conrad M Freuling, Louise Gibson, Hooman Goharriz, Daniel L Horton, Daisy Jennings, Denise A Marston, Yaa Ntiamoa-Baidu, Silke Riesle Sbarbaro, David Selden, Emma L Wise, Thijs Kuiken, Anthony R Fooks, Thomas Müller, James LN Wood, Andrew A Cunningham
Feb 01, 2021
Rabies is a fatal neurologic disease caused by lyssavirus infection. Bats are important natural reservoir hosts of various lyssaviruses that can be transmitted to people. The epidemiology and pathogenesis of rabies in bats are...
Maternal antibody and the maintenance of a lyssavirus in populations of seasonally breeding African bats.
David TS Hayman, Angela D Luis, Olivier Restif, Kate S Baker, Anthony R Fooks, Clint Leach, Daniel L Horton, Richard Suu-Ire, Andrew A Cunningham, James LN Wood, Colleen T Webb
Oct 10, 2018